ENSG00000249592

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000503185 ENSG00000249592 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 11.78826 9.270612 10.33859 1.328148 0.1059716 0.1571419 2.1458315 1.3369424 1.7919704 0.24012072 0.4246619 0.4198872 0.17544167 0.14393333 0.1729667 0.02903333 8.502440e-01 3.056041e-06    
ENST00000503405 ENSG00000249592 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 11.78826 9.270612 10.33859 1.328148 0.1059716 0.1571419 1.2313269 0.2324639 1.2516187 0.06286271 0.1373215 2.3794342 0.10026667 0.02440000 0.1211333 0.09673333 3.056041e-06 3.056041e-06    
ENST00000507446 ENSG00000249592 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 11.78826 9.270612 10.33859 1.328148 0.1059716 0.1571419 0.4843849 0.7565605 0.2525946 0.53959135 0.2525946 -1.5455624 0.04470417 0.09623333 0.0249000 -0.07133333 5.793767e-01 3.056041e-06    
ENST00000652800 ENSG00000249592 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 11.78826 9.270612 10.33859 1.328148 0.1059716 0.1571419 2.1178725 2.0793621 2.6554467 0.14937289 0.1813429 0.3513148 0.18917500 0.22883333 0.2568000 0.02796667 7.340873e-01 3.056041e-06    
ENST00000692343 ENSG00000249592 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 11.78826 9.270612 10.33859 1.328148 0.1059716 0.1571419 1.8981081 1.0138056 1.7306905 0.31513424 0.2410263 0.7657179 0.15591667 0.10480000 0.1671667 0.06236667 2.920257e-01 3.056041e-06 FALSE  
MSTRG.24419.7 ENSG00000249592 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA   11.78826 9.270612 10.33859 1.328148 0.1059716 0.1571419 3.1137492 2.8526977 2.1321954 0.81692092 0.1325015 -0.4182852 0.26121250 0.29640000 0.2063333 -0.09006667 3.240274e-01 3.056041e-06    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000249592 E001 0.6362506 0.4590099236 5.412622e-01 0.6722659766 4 760202 760486 285 - 0.297 0.123 -1.586
ENSG00000249592 E002 13.2997659 0.0229967030 1.379393e-03 0.0052394326 4 760487 762386 1900 - 0.911 1.290 1.369
ENSG00000249592 E003 5.8187854 0.0058718602 2.569904e-01 0.3940244939 4 762387 762740 354 - 0.718 0.877 0.629
ENSG00000249592 E004 2.7196406 0.0057136248 3.413707e-01 0.4852606780 4 762741 762839 99 - 0.470 0.629 0.740
ENSG00000249592 E005 57.0153513 0.0013475844 3.645918e-01 0.5089477595 4 766240 767140 901 - 1.775 1.744 -0.104
ENSG00000249592 E006 51.3039273 0.0252858011 1.018740e-01 0.1933510303 4 767141 767615 475 - 1.633 1.777 0.490
ENSG00000249592 E007 12.3991334 0.0195600827 2.565612e-01 0.3935320879 4 777055 777057 3 - 1.018 1.173 0.559
ENSG00000249592 E008 51.4963680 0.0005667172 6.047185e-03 0.0187355231 4 777058 777420 363 - 1.623 1.764 0.478
ENSG00000249592 E009 31.4934097 0.0017266964 5.723554e-01 0.6984869620 4 777421 777536 116 - 1.472 1.518 0.161
ENSG00000249592 E010 27.4023423 0.0068905986 2.566738e-01 0.3936470087 4 777537 777640 104 - 1.382 1.481 0.341
ENSG00000249592 E011 13.9751137 0.0165979689 8.224237e-01 0.8880375041 4 780149 780245 97 - 1.185 1.166 -0.067
ENSG00000249592 E012 23.0753933 0.0011590493 1.125185e-03 0.0043878721 4 780246 780530 285 - 1.481 1.262 -0.761
ENSG00000249592 E013 13.0993106 0.0036470036 2.846563e-02 0.0689439717 4 780531 780585 55 - 1.229 1.033 -0.701
ENSG00000249592 E014 12.9090563 0.0266929811 2.796624e-01 0.4194238763 4 780586 780631 46 - 1.175 1.079 -0.345
ENSG00000249592 E015 14.8934879 0.0082646817 1.669381e-01 0.2842216792 4 780632 780688 57 - 1.245 1.129 -0.411
ENSG00000249592 E016 8.1418161 0.0022275453 1.918139e-02 0.0497318481 4 780689 780717 29 - 1.069 0.816 -0.953
ENSG00000249592 E017 35.5112456 0.0007144416 1.732005e-05 0.0001089748 4 780724 781568 845 - 1.662 1.427 -0.801
ENSG00000249592 E018 9.7038640 0.1185075929 6.306325e-01 0.7457874851 4 781569 781771 203 - 1.059 0.980 -0.290
ENSG00000249592 E019 18.3441221 0.0011700468 1.563114e-01 0.2702112687 4 781772 781866 95 - 1.212 1.333 0.425