ENSG00000249550

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000547963 ENSG00000249550 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01234 lncRNA lncRNA 5.699667 10.19845 3.772759 1.399746 0.2176197 -1.432253 0.7467562 1.2212447 0.8365382 0.23138038 0.149183695 -0.5404703 0.14282083 0.11890000 0.21956667 0.100666667 0.04955202 0.04955202 FALSE FALSE
ENST00000654810 ENSG00000249550 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01234 lncRNA lncRNA 5.699667 10.19845 3.772759 1.399746 0.2176197 -1.432253 0.3454338 0.3408467 0.1696739 0.06692961 0.002769772 -0.9654600 0.06977083 0.03540000 0.04536667 0.009966667 0.76905945 0.04955202   FALSE
ENST00000655514 ENSG00000249550 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01234 lncRNA lncRNA 5.699667 10.19845 3.772759 1.399746 0.2176197 -1.432253 0.5353071 0.6839100 0.4933889 0.14377055 0.114422098 -0.4630752 0.11606250 0.06876667 0.13270000 0.063933333 0.30587303 0.04955202   FALSE
ENST00000657279 ENSG00000249550 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01234 lncRNA lncRNA 5.699667 10.19845 3.772759 1.399746 0.2176197 -1.432253 3.3171638 6.8589360 2.0313187 1.11437659 0.197628149 -1.7505852 0.52492500 0.66756667 0.53583333 -0.131733333 0.09480617 0.04955202   FALSE
ENST00000662051 ENSG00000249550 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01234 lncRNA lncRNA 5.699667 10.19845 3.772759 1.399746 0.2176197 -1.432253 0.2910640 0.3856881 0.1290766 0.13894895 0.036975889 -1.5084840 0.05611250 0.04050000 0.03433333 -0.006166667 0.96909813 0.04955202   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000249550 E001 0.0000000       12 113583886 113585632 1747 -      
ENSG00000249550 E002 0.1817044 0.0409477480 1.000000e+00   12 113679459 113679740 282 - 0.000 0.079 8.874
ENSG00000249550 E003 0.0000000       12 113693724 113694963 1240 -      
ENSG00000249550 E004 0.1482932 0.0411597534 1.000000e+00   12 113704966 113706870 1905 - 0.000 0.079 10.507
ENSG00000249550 E005 0.3299976 0.0274424043 6.029637e-01   12 113706871 113706976 106 - 0.000 0.145 11.477
ENSG00000249550 E006 3.2866872 0.0097239944 1.842250e-01 3.065349e-01 12 113735840 113736222 383 - 0.414 0.641 1.078
ENSG00000249550 E007 0.6663248 0.0215260439 2.255848e-01 3.571086e-01 12 113737448 113738012 565 - 0.000 0.254 12.381
ENSG00000249550 E008 2.3519018 0.0165897762 2.348533e-01 3.681792e-01 12 113743440 113743656 217 - 0.315 0.529 1.162
ENSG00000249550 E009 9.7644749 0.0660539663 7.540289e-01 8.397618e-01 12 113743657 113744574 918 - 0.954 0.972 0.064
ENSG00000249550 E010 1.1769825 0.0113652168 3.954871e-01 5.392959e-01 12 113744575 113744576 2 - 0.185 0.341 1.164
ENSG00000249550 E011 6.5556187 0.0039245868 1.493767e-01 2.608080e-01 12 113744577 113744730 154 - 0.674 0.867 0.771
ENSG00000249550 E012 39.4032722 0.0056043818 2.606164e-01 3.981758e-01 12 113744731 113745327 597 - 1.612 1.527 -0.290
ENSG00000249550 E013 69.3536243 0.0055225346 8.818188e-07 7.409648e-06 12 113745328 113746595 1268 - 1.954 1.708 -0.830
ENSG00000249550 E014 0.1817044 0.0409477480 1.000000e+00   12 113750498 113750501 4 - 0.000 0.079 10.510
ENSG00000249550 E015 30.6165765 0.0007656312 3.476149e-04 1.570697e-03 12 113750502 113750726 225 - 1.243 1.491 0.863
ENSG00000249550 E016 3.1634865 0.0074431737 2.619760e-01 3.996986e-01 12 113750727 113751013 287 - 0.414 0.601 0.903
ENSG00000249550 E017 11.3958365 0.0019218015 6.305406e-01 7.457161e-01 12 113751014 113752188 1175 - 1.002 1.039 0.136
ENSG00000249550 E018 0.3299976 0.0274424043 6.029637e-01   12 113753431 113753563 133 - 0.000 0.145 11.477
ENSG00000249550 E019 4.1296067 0.0041443651 1.967667e-01 3.222053e-01 12 113757117 113757351 235 - 0.495 0.697 0.902
ENSG00000249550 E020 2.6561265 0.2372915013 7.249833e-01 8.183389e-01 12 113757352 113757742 391 - 0.563 0.484 -0.375
ENSG00000249550 E021 51.6499457 0.0005779510 1.315429e-01 2.362896e-01 12 113767075 113767208 134 - 1.618 1.678 0.207
ENSG00000249550 E022 0.2214452 0.0490643779 1.000000e+00   12 113767209 113767236 28 - 0.000 0.079 10.490
ENSG00000249550 E023 27.1752203 0.0008548513 1.665305e-01 2.836960e-01 12 113773615 113773726 112 - 1.327 1.412 0.297