ENSG00000249395

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000669950 ENSG00000249395 HEK293_OSMI2_2hA HEK293_TMG_2hB CASC9 lncRNA lncRNA 4.773406 5.880457 5.193001 0.4716913 0.4337589 -0.1790356 1.4377808 0.7871905 2.0473506 0.04943466 0.17928027 1.367791 0.31148333 0.1364667 0.40146667 0.26500000 0.0004182618 0.0004182618 TRUE FALSE
ENST00000675897 ENSG00000249395 HEK293_OSMI2_2hA HEK293_TMG_2hB CASC9 lncRNA lncRNA 4.773406 5.880457 5.193001 0.4716913 0.4337589 -0.1790356 0.2002041 0.0000000 0.5031497 0.00000000 0.27327285 5.681308 0.04429583 0.0000000 0.09706667 0.09706667 0.1739242241 0.0004182618   FALSE
ENST00000676364 ENSG00000249395 HEK293_OSMI2_2hA HEK293_TMG_2hB CASC9 lncRNA lncRNA 4.773406 5.880457 5.193001 0.4716913 0.4337589 -0.1790356 0.9154566 1.4876440 0.5794504 0.05732363 0.04222004 -1.345252 0.18741667 0.2566000 0.11203333 -0.14456667 0.0007688488 0.0004182618   FALSE
MSTRG.31669.15 ENSG00000249395 HEK293_OSMI2_2hA HEK293_TMG_2hB CASC9 lncRNA   4.773406 5.880457 5.193001 0.4716913 0.4337589 -0.1790356 1.7037100 3.3608156 1.4009789 0.57746741 0.29791648 -1.256401 0.34830000 0.5639000 0.26573333 -0.29816667 0.0045598111 0.0004182618   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000249395 E001 0.0000000       8 75120409 75120412 4 -      
ENSG00000249395 E002 13.4168604 0.0015167634 2.509316e-05 1.520883e-04 8 75120413 75120707 295 - 0.918 1.298 1.373
ENSG00000249395 E003 0.8114974 0.0565503938 1.377140e-01 2.448982e-01 8 75120708 75120798 91 - 0.115 0.378 2.195
ENSG00000249395 E004 6.3000077 0.0027772733 8.421869e-04 3.409621e-03 8 75121638 75121756 119 - 0.606 1.018 1.636
ENSG00000249395 E005 0.0000000       8 75223115 75223121 7 -      
ENSG00000249395 E006 0.0000000       8 75223122 75223126 5 -      
ENSG00000249395 E007 0.0000000       8 75223127 75223134 8 -      
ENSG00000249395 E008 12.1134147 0.0016897694 1.585953e-04 7.855008e-04 8 75223135 75223317 183 - 1.262 0.883 -1.381
ENSG00000249395 E009 8.7780432 0.0023464965 4.661106e-03 1.498799e-02 8 75223318 75223342 25 - 1.118 0.795 -1.211
ENSG00000249395 E010 12.1948855 0.0014828088 2.859529e-04 1.322807e-03 8 75223343 75223425 83 - 1.262 0.902 -1.308
ENSG00000249395 E011 9.5275059 0.0069799901 2.514051e-03 8.806618e-03 8 75223426 75223452 27 - 1.166 0.818 -1.290
ENSG00000249395 E012 12.6747260 0.0120808782 9.758682e-03 2.816933e-02 8 75223453 75223543 91 - 1.255 0.972 -1.020
ENSG00000249395 E013 12.3639659 0.0024164728 1.317207e-02 3.631165e-02 8 75223544 75223671 128 - 1.232 0.988 -0.881
ENSG00000249395 E014 33.3790138 0.0098269916 3.473384e-12 7.803869e-11 8 75223672 75224358 687 - 1.728 1.205 -1.802
ENSG00000249395 E015 0.1817044 0.0403388034 4.163452e-01   8 75232218 75232249 32 - 0.000 0.130 10.718
ENSG00000249395 E016 0.0000000       8 75243804 75243835 32 -      
ENSG00000249395 E017 0.0000000       8 75271314 75271433 120 -      
ENSG00000249395 E018 0.8073328 0.0162781684 7.927978e-01 8.675150e-01 8 75276987 75277090 104 - 0.281 0.230 -0.382
ENSG00000249395 E019 2.4711138 0.0072436763 2.794568e-01 4.192084e-01 8 75278357 75278481 125 - 0.450 0.617 0.787
ENSG00000249395 E020 0.5931727 0.7399891042 2.314746e-01 3.642309e-01 8 75278482 75278637 156 - 0.000 0.358 12.591
ENSG00000249395 E021 0.1515154 0.0419205823 5.676105e-01   8 75278713 75278924 212 - 0.115 0.000 -10.587
ENSG00000249395 E022 28.8161899 0.0009006728 2.651467e-18 1.386454e-16 8 75313420 75313735 316 - 1.076 1.657 2.023
ENSG00000249395 E023 31.5492662 0.0008021709 1.286467e-04 6.530298e-04 8 75324221 75324333 113 - 1.381 1.596 0.737
ENSG00000249395 E024 22.2385021 0.0140293725 2.337756e-01 3.668783e-01 8 75324334 75324564 231 - 1.323 1.414 0.317
ENSG00000249395 E025 17.6284901 0.0010665386 9.994210e-03 2.874802e-02 8 75324565 75324785 221 - 1.157 1.348 0.675
ENSG00000249395 E026 0.0000000       8 75344104 75344185 82 -      
ENSG00000249395 E027 0.0000000       8 75351873 75352026 154 -      
ENSG00000249395 E028 0.0000000       8 75352166 75352327 162 -