ENSG00000248932

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000504670 ENSG00000248932 HEK293_OSMI2_2hA HEK293_TMG_2hB COPB2-DT lncRNA lncRNA 2.191951 1.957352 2.593632 0.1616673 0.1387893 0.4042705 0.12659089 0.00000000 0.20746986 0.000000000 0.04220441 4.4427436 0.05291667 0.00000000 0.07890000 0.07890000 0.0009120485 0.0009120485    
ENST00000514729 ENSG00000248932 HEK293_OSMI2_2hA HEK293_TMG_2hB COPB2-DT lncRNA lncRNA 2.191951 1.957352 2.593632 0.1616673 0.1387893 0.4042705 0.10755214 0.00000000 0.26402368 0.000000000 0.15100068 4.7762287 0.04876250 0.00000000 0.09610000 0.09610000 0.2267022382 0.0009120485    
ENST00000653359 ENSG00000248932 HEK293_OSMI2_2hA HEK293_TMG_2hB COPB2-DT lncRNA lncRNA 2.191951 1.957352 2.593632 0.1616673 0.1387893 0.4042705 0.48215950 0.50752262 0.71920415 0.201117304 0.16489664 0.4947008 0.21527917 0.24893333 0.28483333 0.03590000 0.9007639004 0.0009120485    
ENST00000659546 ENSG00000248932 HEK293_OSMI2_2hA HEK293_TMG_2hB COPB2-DT lncRNA lncRNA 2.191951 1.957352 2.593632 0.1616673 0.1387893 0.4042705 0.08952455 0.00000000 0.22965221 0.000000000 0.12655329 4.5828703 0.03847083 0.00000000 0.09146667 0.09146667 0.2417270707 0.0009120485    
ENST00000660194 ENSG00000248932 HEK293_OSMI2_2hA HEK293_TMG_2hB COPB2-DT lncRNA lncRNA 2.191951 1.957352 2.593632 0.1616673 0.1387893 0.4042705 0.12056755 0.03440621 0.22691661 0.004756035 0.02597370 2.4155458 0.05527083 0.01763333 0.08866667 0.07103333 0.0242823320 0.0009120485    
ENST00000685603 ENSG00000248932 HEK293_OSMI2_2hA HEK293_TMG_2hB COPB2-DT lncRNA lncRNA 2.191951 1.957352 2.593632 0.1616673 0.1387893 0.4042705 0.26732141 0.53085369 0.06580522 0.270933256 0.06580522 -2.8348693 0.12393333 0.27786667 0.02543333 -0.25243333 0.3749602736 0.0009120485    
ENST00000686351 ENSG00000248932 HEK293_OSMI2_2hA HEK293_TMG_2hB COPB2-DT lncRNA lncRNA 2.191951 1.957352 2.593632 0.1616673 0.1387893 0.4042705 0.41938884 0.46027747 0.21609658 0.083921780 0.08656187 -1.0565730 0.19697500 0.23700000 0.08706667 -0.14993333 0.1064089722 0.0009120485    
ENST00000690901 ENSG00000248932 HEK293_OSMI2_2hA HEK293_TMG_2hB COPB2-DT lncRNA lncRNA 2.191951 1.957352 2.593632 0.1616673 0.1387893 0.4042705 0.16521147 0.12891342 0.38424848 0.128913415 0.21826645 1.5049193 0.07071250 0.05710000 0.13993333 0.08283333 0.6855838402 0.0009120485    
ENST00000691594 ENSG00000248932 HEK293_OSMI2_2hA HEK293_TMG_2hB COPB2-DT lncRNA lncRNA 2.191951 1.957352 2.593632 0.1616673 0.1387893 0.4042705 0.08429945 0.15591668 0.00000000 0.087231520 0.00000000 -4.0523870 0.04338750 0.08513333 0.00000000 -0.08513333 0.1719859248 0.0009120485    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000248932 E001 0.0000000       3 139389761 139389784 24 +      
ENSG00000248932 E002 0.0000000       3 139389785 139389799 15 +      
ENSG00000248932 E003 0.0000000       3 139389800 139389805 6 +      
ENSG00000248932 E004 0.1515154 0.042822008 6.478707e-01   3 139389806 139389814 9 + 0.110 0.000 -10.970
ENSG00000248932 E005 0.7406253 0.015484783 3.765714e-02 8.668957e-02 3 139389815 139389817 3 + 0.387 0.000 -14.920
ENSG00000248932 E006 1.4468057 0.010743912 2.086647e-01 3.369034e-01 3 139389818 139389829 12 + 0.479 0.240 -1.445
ENSG00000248932 E007 3.6923096 0.004263818 4.545509e-01 5.951819e-01 3 139389830 139389837 8 + 0.725 0.597 -0.545
ENSG00000248932 E008 5.1672003 0.004365410 6.761824e-01 7.812282e-01 3 139389838 139389839 2 + 0.810 0.735 -0.300
ENSG00000248932 E009 5.8325826 0.012070334 5.463399e-01 6.765398e-01 3 139389840 139389844 5 + 0.864 0.765 -0.391
ENSG00000248932 E010 7.2342472 0.002567289 8.366590e-01 8.978584e-01 3 139389845 139389854 10 + 0.928 0.883 -0.168
ENSG00000248932 E011 7.2342472 0.002567289 8.366590e-01 8.978584e-01 3 139389855 139389855 1 + 0.928 0.883 -0.168
ENSG00000248932 E012 10.4900211 0.001798905 6.849939e-01 7.878029e-01 3 139389856 139389875 20 + 1.086 1.025 -0.224
ENSG00000248932 E013 17.4281312 0.001146928 2.228863e-01 3.538103e-01 3 139389876 139389933 58 + 1.232 1.305 0.254
ENSG00000248932 E014 9.9244784 0.001912133 6.569399e-02 1.361998e-01 3 139389934 139389998 65 + 0.956 1.119 0.598
ENSG00000248932 E015 17.8151943 0.001324999 6.769011e-03 2.062283e-02 3 139389999 139390237 239 + 1.178 1.364 0.653
ENSG00000248932 E016 4.1707127 0.004505726 5.745641e-01 7.003522e-01 3 139390238 139390247 10 + 0.675 0.735 0.247
ENSG00000248932 E017 3.5062476 0.004702773 1.802081e-01 3.014373e-01 3 139390248 139390429 182 + 0.554 0.735 0.776
ENSG00000248932 E018 1.7662047 0.079366937 1.060819e-01 1.997383e-01 3 139390430 139390869 440 + 0.270 0.557 1.596
ENSG00000248932 E019 7.9789735 0.003372626 3.577045e-01 5.021194e-01 3 139419557 139419580 24 + 0.913 0.993 0.302
ENSG00000248932 E020 13.1316879 0.012259352 2.221856e-01 3.530157e-01 3 139419581 139419680 100 + 1.097 1.197 0.360
ENSG00000248932 E021 17.4345481 0.001138397 2.669592e-01 4.052341e-01 3 139423016 139423114 99 + 1.232 1.297 0.226
ENSG00000248932 E022 0.2214452 0.038094487 3.630910e-01   3 139423115 139423393 279 + 0.000 0.137 12.620
ENSG00000248932 E023 0.1482932 0.041356082 3.657101e-01   3 139436725 139436884 160 + 0.000 0.136 12.610
ENSG00000248932 E024 23.1877426 0.026644483 6.373313e-03 1.959342e-02 3 139444294 139445101 808 + 1.254 1.498 0.844
ENSG00000248932 E025 0.8438776 0.427694382 6.488210e-01 7.602655e-01 3 139450280 139450413 134 + 0.197 0.326 0.958
ENSG00000248932 E026 0.5985731 0.021180255 4.738684e-01 6.127637e-01 3 139452001 139452240 240 + 0.270 0.136 -1.226
ENSG00000248932 E027 0.7427016 0.015753307 3.759241e-02 8.656897e-02 3 139459931 139459985 55 + 0.387 0.000 -14.920
ENSG00000248932 E028 0.0000000       3 139539916 139540224 309 +      
ENSG00000248932 E029 0.7373885 0.511221856 8.220703e-01 8.877967e-01 3 139561653 139561748 96 + 0.197 0.251 0.446
ENSG00000248932 E030 1.1749829 0.249673496 5.461974e-01 6.764074e-01 3 139577792 139577850 59 + 0.386 0.246 -0.910
ENSG00000248932 E031 0.7279398 0.269324133 9.194528e-02 1.781421e-01 3 139578815 139579095 281 + 0.385 0.000 -14.803
ENSG00000248932 E032 3.3077869 0.054857000 2.972448e-04 1.368578e-03 3 139583129 139583880 752 + 0.846 0.137 -4.023
ENSG00000248932 E033 16.8399122 0.001350883 1.860002e-09 2.621423e-08 3 139599764 139603166 3403 + 1.438 0.883 -1.992
ENSG00000248932 E034 1.1135859 0.011331308 1.107201e-01 2.065909e-01 3 139603167 139603428 262 + 0.435 0.136 -2.223
ENSG00000248932 E035 2.7855010 0.106526897 2.064982e-04 9.917977e-04 3 139603429 139604965 1537 + 0.809 0.000 -16.308
ENSG00000248932 E036 0.7384352 0.020342669 3.807076e-02 8.748231e-02 3 139604966 139605051 86 + 0.387 0.000 -14.918
ENSG00000248932 E037 0.7384352 0.020342669 3.807076e-02 8.748231e-02 3 139605052 139605196 145 + 0.387 0.000 -14.918
ENSG00000248932 E038 0.7341688 0.349003938 1.093278e-01 2.045753e-01 3 139605197 139606188 992 + 0.386 0.000 -14.772
ENSG00000248932 E039 0.1515154 0.042822008 6.478707e-01   3 139606189 139606295 107 + 0.110 0.000 -12.916
ENSG00000248932 E040 1.1426289 0.011469697 9.830058e-01 9.934518e-01 3 139606296 139606642 347 + 0.332 0.324 -0.053
ENSG00000248932 E041 2.8734373 0.005493505 2.018860e-01 3.285516e-01 3 139608086 139609610 1525 + 0.675 0.454 -1.016
ENSG00000248932 E042 0.0000000       3 139781443 139781567 125 +      
ENSG00000248932 E043 0.0000000       3 139781654 139782699 1046 +