ENSG00000248367

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000504573 ENSG00000248367 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 6.48569 10.68358 3.200657 1.060462 0.4161423 -1.735805 1.131354 1.4017252 0.8905629 0.1558811 0.1670330 -0.6485603 0.2008792 0.13556667 0.2772333 0.141666667 0.04299673 0.04299673   FALSE
ENST00000689182 ENSG00000248367 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 6.48569 10.68358 3.200657 1.060462 0.4161423 -1.735805 1.150990 0.9039542 0.5376756 0.2408759 0.1603965 -0.7388003 0.1820125 0.08376667 0.1648333 0.081066667 0.27080100 0.04299673   FALSE
ENST00000691211 ENSG00000248367 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 6.48569 10.68358 3.200657 1.060462 0.4161423 -1.735805 1.331946 3.9114906 0.4491384 0.2407923 0.2790937 -3.0944010 0.1899917 0.37650000 0.1236667 -0.252833333 0.24122354 0.04299673 FALSE FALSE
MSTRG.27453.3 ENSG00000248367 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA   6.48569 10.68358 3.200657 1.060462 0.4161423 -1.735805 2.249296 3.9819981 1.1671863 1.1530198 0.1369090 -1.7617683 0.3449625 0.36036667 0.3684000 0.008033333 0.97794479 0.04299673 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000248367 E001 0.3332198 0.0281338584 0.4552505345   5 180292178 180292184 7 + 0.198 0.073 -1.647
ENSG00000248367 E002 0.4847352 0.0866773954 0.1682607941 0.285936641 5 180292185 180292192 8 + 0.333 0.073 -2.651
ENSG00000248367 E003 6.7001360 0.0027598847 0.6962044661 0.796628801 5 180292193 180292239 47 + 0.792 0.801 0.039
ENSG00000248367 E004 19.3682639 0.0017821967 0.2974156368 0.438751753 5 180292240 180292279 40 + 1.171 1.217 0.160
ENSG00000248367 E005 19.5165571 0.0013175330 0.2694985992 0.408004964 5 180292280 180292300 21 + 1.171 1.221 0.176
ENSG00000248367 E006 18.1505705 0.0201636341 0.6503222912 0.761368512 5 180292301 180292408 108 + 1.172 1.185 0.047
ENSG00000248367 E007 13.2121943 0.0156656248 0.0685531410 0.140970474 5 180292409 180292465 57 + 0.899 1.086 0.693
ENSG00000248367 E008 7.4007998 0.0023264649 0.0071553167 0.021626156 5 180292466 180292481 16 + 0.519 0.892 1.560
ENSG00000248367 E009 22.4543966 0.0682468622 0.0008615085 0.003478923 5 180293176 180293418 243 + 1.598 1.149 -1.561
ENSG00000248367 E010 9.1734173 0.0020573966 0.0423498119 0.095362583 5 180293933 180293984 52 + 1.118 0.849 -0.998
ENSG00000248367 E011 18.1153980 0.0383721744 0.4197778569 0.563042154 5 180294971 180295034 64 + 1.315 1.161 -0.545
ENSG00000248367 E012 43.9407212 0.0009264169 0.0043456768 0.014110713 5 180295035 180295256 222 + 1.466 1.581 0.394