ENSG00000248049

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000506606 ENSG00000248049 HEK293_OSMI2_2hA HEK293_TMG_2hB UBA6-DT lncRNA lncRNA 6.67841 7.993694 5.486433 0.8699937 0.2803725 -0.5421702 2.7943249 3.2653261 2.2169605 0.2484195 0.23444375 -0.55656256 0.42311667 0.4114667 0.4106667 -0.00080000 1.000000e+00 1.31394e-15   FALSE
ENST00000654961 ENSG00000248049 HEK293_OSMI2_2hA HEK293_TMG_2hB UBA6-DT lncRNA lncRNA 6.67841 7.993694 5.486433 0.8699937 0.2803725 -0.5421702 0.9603596 0.9240353 0.8943933 0.1994292 0.18224482 -0.04652682 0.14922083 0.1128667 0.1628000 0.04993333 5.310587e-01 1.31394e-15 TRUE FALSE
ENST00000666396 ENSG00000248049 HEK293_OSMI2_2hA HEK293_TMG_2hB UBA6-DT lncRNA lncRNA 6.67841 7.993694 5.486433 0.8699937 0.2803725 -0.5421702 0.2927404 0.0000000 0.6769259 0.0000000 0.05261417 6.10208258 0.04775417 0.0000000 0.1234667 0.12346667 1.313940e-15 1.31394e-15 FALSE FALSE
ENST00000693410 ENSG00000248049 HEK293_OSMI2_2hA HEK293_TMG_2hB UBA6-DT lncRNA lncRNA 6.67841 7.993694 5.486433 0.8699937 0.2803725 -0.5421702 1.9543959 2.8374462 1.2616598 0.4206478 0.28334791 -1.16295577 0.28142083 0.3526333 0.2262000 -0.12643333 1.983281e-01 1.31394e-15 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000248049 E001 0.0000000       4 67701209 67701260 52 +      
ENSG00000248049 E002 0.0000000       4 67701261 67701269 9 +      
ENSG00000248049 E003 0.3289534 0.0287044976 0.8067040380   4 67701270 67701272 3 + 0.140 0.107 -0.455
ENSG00000248049 E004 0.3289534 0.0287044976 0.8067040380   4 67701273 67701278 6 + 0.140 0.107 -0.455
ENSG00000248049 E005 0.3289534 0.0287044976 0.8067040380   4 67701279 67701279 1 + 0.140 0.107 -0.455
ENSG00000248049 E006 0.3289534 0.0287044976 0.8067040380   4 67701280 67701283 4 + 0.140 0.107 -0.455
ENSG00000248049 E007 1.2813702 0.0277104618 0.8265113058 0.8908338683 4 67701284 67701302 19 + 0.331 0.378 0.278
ENSG00000248049 E008 3.0777402 0.0233634918 0.6443525854 0.7566754331 4 67701303 67701332 30 + 0.646 0.577 -0.304
ENSG00000248049 E009 3.2260334 0.0150835240 0.7680692615 0.8501416483 4 67701333 67701336 4 + 0.646 0.608 -0.168
ENSG00000248049 E010 13.3528311 0.0063332312 0.2035449837 0.3306511710 4 67701337 67701360 24 + 1.221 1.111 -0.392
ENSG00000248049 E011 32.8926244 0.0006703150 0.4296203378 0.5723312371 4 67701361 67701389 29 + 1.543 1.507 -0.125
ENSG00000248049 E012 33.6373140 0.0006658458 0.3912061089 0.5351338232 4 67701390 67701394 5 + 1.557 1.518 -0.135
ENSG00000248049 E013 56.4695220 0.0004578716 0.5522786956 0.6815682499 4 67701395 67701484 90 + 1.762 1.746 -0.054
ENSG00000248049 E014 1.8005332 0.0405222451 0.1611366516 0.2765890353 4 67716923 67717021 99 + 0.246 0.510 1.552
ENSG00000248049 E015 67.9921237 0.0004002509 0.0010240558 0.0040415038 4 67720422 67720615 194 + 1.905 1.783 -0.409
ENSG00000248049 E016 16.9952833 0.0010929040 0.0245802098 0.0610107697 4 67720616 67720621 6 + 1.349 1.181 -0.592
ENSG00000248049 E017 16.0710809 0.0011711412 0.0092939019 0.0270196563 4 67720622 67720632 11 + 1.342 1.139 -0.714
ENSG00000248049 E018 83.6782691 0.0003435199 0.8637445957 0.9161463875 4 67720633 67721051 419 + 1.917 1.922 0.016
ENSG00000248049 E019 55.2288633 0.0044463262 0.2509877968 0.3871270926 4 67721052 67721476 425 + 1.694 1.763 0.233
ENSG00000248049 E020 234.3351554 0.0025135467 0.0001624213 0.0008023736 4 67721477 67723914 2438 + 2.295 2.399 0.347
ENSG00000248049 E021 19.3664269 0.0013473341 0.1382764114 0.2456969497 4 67728540 67728686 147 + 1.221 1.350 0.452
ENSG00000248049 E022 5.3452013 0.0043075542 0.1968523923 0.3223007300 4 67730074 67730079 6 + 0.682 0.868 0.743
ENSG00000248049 E023 7.7098536 0.0179445692 0.6701164774 0.7766616274 4 67730080 67730170 91 + 0.895 0.966 0.268
ENSG00000248049 E024 0.1482932 0.0411597534 0.6479121032   4 67730171 67730202 32 + 0.000 0.106 11.396
ENSG00000248049 E025 11.3440427 0.0268068440 0.0042230052 0.0137661859 4 67731506 67732143 638 + 1.259 0.927 -1.203
ENSG00000248049 E026 2.6622814 0.0077783503 0.4082800854 0.5518785709 4 67732144 67732345 202 + 0.463 0.608 0.680
ENSG00000248049 E027 0.8964071 0.1771883906 0.0091475839 0.0266504983 4 67732346 67732722 377 + 0.518 0.000 -14.783
ENSG00000248049 E028 0.0000000       4 67745827 67747235 1409 +      
ENSG00000248049 E029 0.2924217 0.0290785164 0.1274468757   4 67747236 67749479 2244 + 0.246 0.000 -13.888
ENSG00000248049 E030 0.0000000       4 67751681 67751714 34 +      
ENSG00000248049 E031 0.1472490 0.0436117190 0.3619591377   4 67753621 67753718 98 + 0.140 0.000 -12.827
ENSG00000248049 E032 0.1515154 0.0429447303 0.3619694685   4 67754159 67754240 82 + 0.140 0.000 -12.832
ENSG00000248049 E033 0.2214452 0.0498112244 0.6425797516   4 67755189 67755255 67 + 0.000 0.107 11.360
ENSG00000248049 E034 0.2944980 0.3956568735 0.2097859007   4 67768858 67770977 2120 + 0.246 0.000 -12.991
ENSG00000248049 E035 0.0000000       4 67790448 67790511 64 +      
ENSG00000248049 E036 0.1482932 0.0411597534 0.6479121032   4 67802282 67802419 138 + 0.000 0.106 11.396
ENSG00000248049 E037 0.2214452 0.0498112244 0.6425797516   4 68018508 68018645 138 + 0.000 0.107 11.360
ENSG00000248049 E038 0.0000000       4 68019227 68019229 3 +      
ENSG00000248049 E039 0.0000000       4 68019230 68019433 204 +      
ENSG00000248049 E040 0.0000000       4 68062607 68063061 455 +      
ENSG00000248049 E041 0.0000000       4 68063062 68063082 21 +      
ENSG00000248049 E042 0.0000000       4 68063083 68063221 139 +      
ENSG00000248049 E043 0.0000000       4 68077279 68077421 143 +      
ENSG00000248049 E044 0.0000000       4 68077463 68077630 168 +      
ENSG00000248049 E045 0.0000000       4 68080121 68080952 832 +