ENSG00000247137

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000528524 ENSG00000247137 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD42-DT lncRNA lncRNA 4.461739 7.098575 3.839903 0.4089825 0.2256298 -0.8847382 1.0038638 3.2835241 0.3516754 1.65365234 0.35167544 -3.1868646 0.1835833 0.44383333 0.0958000 -0.3480333 4.399429e-01 8.918596e-08   FALSE
ENST00000529031 ENSG00000247137 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD42-DT lncRNA lncRNA 4.461739 7.098575 3.839903 0.4089825 0.2256298 -0.8847382 0.7881160 1.1707752 0.7921631 0.10181254 0.32843848 -0.5577668 0.1705833 0.16700000 0.1990000 0.0320000 9.445469e-01 8.918596e-08   FALSE
ENST00000602381 ENSG00000247137 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD42-DT lncRNA lncRNA 4.461739 7.098575 3.839903 0.4089825 0.2256298 -0.8847382 0.2509169 0.2612653 0.1598177 0.09077101 0.07209364 -0.6757171 0.0586125 0.03640000 0.0427000 0.0063000 9.678943e-01 8.918596e-08   FALSE
ENST00000665524 ENSG00000247137 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD42-DT lncRNA lncRNA 4.461739 7.098575 3.839903 0.4089825 0.2256298 -0.8847382 0.6936639 0.2404704 0.7619597 0.03507454 0.06416423 1.6238856 0.1769875 0.03463333 0.1994000 0.1647667 8.918596e-08 8.918596e-08   FALSE
MSTRG.6098.2 ENSG00000247137 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD42-DT lncRNA   4.461739 7.098575 3.839903 0.4089825 0.2256298 -0.8847382 1.1830335 0.8107934 1.4127982 0.46607873 0.40963686 0.7936399 0.2912250 0.11993333 0.3674667 0.2475333 1.739661e-01 8.918596e-08   FALSE
MSTRG.6098.3 ENSG00000247137 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD42-DT lncRNA   4.461739 7.098575 3.839903 0.4089825 0.2256298 -0.8847382 0.1478789 1.0263375 0.0000000 1.02633747 0.00000000 -6.6953501 0.0256625 0.15783333 0.0000000 -0.1578333 9.200650e-01 8.918596e-08   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000247137 E001 2.497163 0.0064145447 4.332250e-01 5.756331e-01 11 83184491 83184853 363 - 0.462 0.579 0.555
ENSG00000247137 E002 6.082974 0.0031188667 1.948749e-03 7.068171e-03 11 83187704 83187821 118 - 1.036 0.638 -1.559
ENSG00000247137 E003 1.866214 0.0368453357 3.357330e-01 4.795349e-01 11 83189562 83189602 41 - 0.563 0.379 -0.933
ENSG00000247137 E004 9.020041 0.0021469323 6.957062e-06 4.794800e-05 11 83190474 83190905 432 - 1.229 0.737 -1.837
ENSG00000247137 E005 5.106258 0.0035429545 1.709889e-04 8.393361e-04 11 83190906 83191028 123 - 1.021 0.509 -2.088
ENSG00000247137 E006 3.487324 0.0047671840 2.023623e-02 5.197986e-02 11 83191029 83191054 26 - 0.826 0.470 -1.543
ENSG00000247137 E007 4.221515 0.0040192030 2.878648e-01 4.284135e-01 11 83191055 83191062 8 - 0.800 0.638 -0.666
ENSG00000247137 E008 3.785997 0.0044808352 6.696763e-01 7.763834e-01 11 83191063 83191064 2 - 0.714 0.638 -0.318
ENSG00000247137 E009 24.361946 0.0009367672 7.005864e-04 2.901134e-03 11 83191065 83191168 104 - 1.248 1.469 0.768
ENSG00000247137 E010 11.674082 0.0016342818 6.899442e-07 5.932368e-06 11 83191169 83192019 851 - 1.325 0.836 -1.779
ENSG00000247137 E011 1.659733 0.0091320969 9.370703e-03 2.720901e-02 11 83192020 83192123 104 - 0.645 0.192 -2.615
ENSG00000247137 E012 1.039390 0.0119441720 1.263655e-03 4.855601e-03 11 83192124 83192136 13 - 0.563 0.000 -11.483
ENSG00000247137 E013 3.343413 0.0786405946 6.570826e-04 2.741479e-03 11 83192137 83192197 61 - 0.914 0.265 -3.101
ENSG00000247137 E014 4.289576 0.0665146485 1.054401e-03 4.147697e-03 11 83192198 83192272 75 - 0.987 0.380 -2.637
ENSG00000247137 E015 5.107302 0.0036124241 6.916775e-04 2.868820e-03 11 83192273 83192427 155 - 1.005 0.545 -1.859
ENSG00000247137 E016 11.531430 0.0041096494 1.755949e-01 2.954609e-01 11 83192428 83192541 114 - 1.177 1.031 -0.526
ENSG00000247137 E017 3.482594 0.0193758066 4.427482e-04 1.938822e-03 11 83192542 83192735 194 - 0.894 0.326 -2.610
ENSG00000247137 E018 33.507238 0.0011486965 4.214575e-05 2.416436e-04 11 83192736 83192792 57 - 1.376 1.605 0.786
ENSG00000247137 E019 33.532098 0.0008021709 1.143906e-07 1.149592e-06 11 83192793 83192816 24 - 1.317 1.623 1.054
ENSG00000247137 E020 2.311180 0.0350512429 6.710335e-01 7.773677e-01 11 83192817 83193200 384 - 0.563 0.471 -0.440
ENSG00000247137 E021 47.824046 0.0011306572 8.632774e-08 8.871457e-07 11 83193467 83193794 328 - 1.507 1.756 0.848