ENSG00000246763

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000498871 ENSG00000246763 HEK293_OSMI2_2hA HEK293_TMG_2hB RGMB-AS1 lncRNA lncRNA 1.673126 2.606143 1.063123 0.1856695 0.2436942 -1.285625 0.09514106 0.14729751 0.04487026 0.07426359 0.04487026 -1.5193995 0.05506250 0.06016667 0.06626667 0.0061000 0.84038861 0.02071222   FALSE
ENST00000501938 ENSG00000246763 HEK293_OSMI2_2hA HEK293_TMG_2hB RGMB-AS1 lncRNA lncRNA 1.673126 2.606143 1.063123 0.1856695 0.2436942 -1.285625 0.12133138 0.06631356 0.12946465 0.06631356 0.06613413 0.8698881 0.11107917 0.02266667 0.11026667 0.0876000 0.41776408 0.02071222   FALSE
ENST00000505677 ENSG00000246763 HEK293_OSMI2_2hA HEK293_TMG_2hB RGMB-AS1 lncRNA lncRNA 1.673126 2.606143 1.063123 0.1856695 0.2436942 -1.285625 1.26559760 2.22763393 0.60601153 0.12902650 0.03805838 -1.8609448 0.70496667 0.85640000 0.61626667 -0.2401333 0.06564446 0.02071222   FALSE
ENST00000515003 ENSG00000246763 HEK293_OSMI2_2hA HEK293_TMG_2hB RGMB-AS1 lncRNA lncRNA 1.673126 2.606143 1.063123 0.1856695 0.2436942 -1.285625 0.05457052 0.00000000 0.13205315 0.00000000 0.06690512 3.8283589 0.04387083 0.00000000 0.10763333 0.1076333 0.02071222 0.02071222   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000246763 E001 7.4930883 0.004557949 0.74162675 0.83071268 5 98769618 98770757 1140 - 0.917 0.877 -0.154
ENSG00000246763 E002 1.8466313 0.008449084 0.87603286 0.92438771 5 98770758 98770849 92 - 0.450 0.420 -0.155
ENSG00000246763 E003 1.8789111 0.008744568 0.58203435 0.70646011 5 98770850 98770949 100 - 0.515 0.420 -0.479
ENSG00000246763 E004 0.9264943 0.014854629 0.42576523 0.56867255 5 98770950 98770954 5 - 0.373 0.230 -0.965
ENSG00000246763 E005 0.9264943 0.014854629 0.42576523 0.56867255 5 98770955 98770958 4 - 0.373 0.230 -0.965
ENSG00000246763 E006 3.9125442 0.020124910 0.92689973 0.95799394 5 98770959 98771079 121 - 0.666 0.673 0.031
ENSG00000246763 E007 8.8846173 0.002259952 0.12060484 0.22082770 5 98771080 98771180 101 - 0.839 1.004 0.623
ENSG00000246763 E008 6.6037050 0.003220097 0.90821306 0.94571198 5 98771181 98771184 4 - 0.839 0.849 0.038
ENSG00000246763 E009 0.6633060 0.019016278 0.09930418 0.18942827 5 98771656 98771766 111 - 0.373 0.091 -2.545
ENSG00000246763 E010 1.3503591 0.015984712 0.00790331 0.02353514 5 98772622 98772715 94 - 0.621 0.166 -2.770
ENSG00000246763 E011 1.4695060 0.010111179 0.18739145 0.31044876 5 98772716 98772798 83 - 0.515 0.286 -1.283
ENSG00000246763 E012 0.4783925 0.022556936 0.25517782 0.39200999 5 98772799 98772966 168 - 0.281 0.091 -1.962
ENSG00000246763 E013 1.1448190 0.012159294 0.21662338 0.34632649 5 98772967 98773139 173 - 0.450 0.230 -1.377
ENSG00000246763 E014 9.6962124 0.002146932 0.00412569 0.01349377 5 98773308 98773469 162 - 0.744 1.061 1.209