ENSG00000246695

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000500102 ENSG00000246695 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.072842 2.396989 2.090297 0.2448258 0.06112766 -0.196636 0.69437551 1.12507310 0.3293583 0.150399664 0.16491944 -1.7419042 0.31083750 0.46606667 0.15600000 -0.310066667 0.23598063 0.01261585   FALSE
ENST00000500276 ENSG00000246695 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.072842 2.396989 2.090297 0.2448258 0.06112766 -0.196636 0.29516635 0.38344712 0.4362024 0.075135658 0.03896579 0.1815285 0.14041667 0.16716667 0.20826667 0.041100000 0.68359536 0.01261585   FALSE
ENST00000546134 ENSG00000246695 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.072842 2.396989 2.090297 0.2448258 0.06112766 -0.196636 0.19914599 0.29505795 0.2401823 0.120655868 0.04321212 -0.2861039 0.08939167 0.11536667 0.11393333 -0.001433333 1.00000000 0.01261585   FALSE
ENST00000658700 ENSG00000246695 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.072842 2.396989 2.090297 0.2448258 0.06112766 -0.196636 0.25257298 0.12482262 0.2928515 0.008572797 0.05551642 1.1675482 0.13279167 0.05410000 0.14120000 0.087100000 0.07069943 0.01261585   FALSE
ENST00000670839 ENSG00000246695 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.072842 2.396989 2.090297 0.2448258 0.06112766 -0.196636 0.06937507 0.04712201 0.1443487 0.018043468 0.05083793 1.4340746 0.03742083 0.01913333 0.07023333 0.051100000 0.33922908 0.01261585   FALSE
MSTRG.6974.9 ENSG00000246695 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   2.072842 2.396989 2.090297 0.2448258 0.06112766 -0.196636 0.11154321 0.05753855 0.4138926 0.057538552 0.07099806 2.6499156 0.05150833 0.02193333 0.19883333 0.176900000 0.01261585 0.01261585   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000246695 E001 1.4175591 0.014082872 7.962179e-01 0.869907500 12 25936683 25937475 793 - 0.414 0.367 -0.266
ENSG00000246695 E002 3.8289390 0.024147059 5.751724e-03 0.017959633 12 25937476 25939506 2031 - 0.868 0.425 -1.941
ENSG00000246695 E003 0.4741261 0.021153978 6.055353e-01 0.725899353 12 25944857 25944871 15 - 0.214 0.125 -0.940
ENSG00000246695 E004 7.0771305 0.002549588 8.635501e-01 0.915991628 12 25944872 25945140 269 - 0.904 0.919 0.058
ENSG00000246695 E005 3.7652727 0.004517874 7.761820e-01 0.855890154 12 25945141 25945181 41 - 0.711 0.667 -0.184
ENSG00000246695 E006 6.7180012 0.002571296 8.877235e-01 0.932229538 12 25945182 25945340 159 - 0.904 0.883 -0.079
ENSG00000246695 E007 20.2542423 0.001175513 1.020650e-01 0.193654618 12 25945341 25946135 795 - 1.261 1.373 0.392
ENSG00000246695 E008 5.0907650 0.003496340 5.805245e-01 0.705253395 12 25946136 25946753 618 - 0.829 0.752 -0.304
ENSG00000246695 E009 4.7089845 0.074095265 3.906936e-02 0.089326247 12 25946754 25947518 765 - 0.905 0.528 -1.566
ENSG00000246695 E010 1.6992554 0.305311330 3.164086e-01 0.459170239 12 25947519 25947531 13 - 0.291 0.521 1.280
ENSG00000246695 E011 4.2425788 0.096894956 7.769367e-01 0.856393322 12 25947532 25947622 91 - 0.683 0.731 0.199
ENSG00000246695 E012 0.4460135 0.025137840 9.558207e-02 0.183765854 12 25952449 25952540 92 - 0.292 0.000 -10.079
ENSG00000246695 E013 1.4006084 0.063698768 1.405724e-01 0.248818337 12 25952541 25952757 217 - 0.510 0.222 -1.746
ENSG00000246695 E014 3.9136531 0.004208886 7.835280e-01 0.861083570 12 25952758 25952862 105 - 0.711 0.668 -0.182
ENSG00000246695 E015 3.3664767 0.004837733 3.329431e-01 0.476617432 12 25952863 25953007 145 - 0.711 0.563 -0.642
ENSG00000246695 E016 2.0617243 0.052540323 9.466156e-02 0.182377358 12 25953008 25953076 69 - 0.622 0.301 -1.670
ENSG00000246695 E017 1.2231704 0.011364144 3.165330e-02 0.075174857 12 25953077 25953242 166 - 0.510 0.125 -2.748
ENSG00000246695 E018 10.2153731 0.001908115 7.034686e-03 0.021315017 12 25953243 25954654 1412 - 1.177 0.902 -1.009
ENSG00000246695 E019 0.8941153 0.021130564 4.503230e-01 0.591424914 12 25954655 25954656 2 - 0.357 0.221 -0.945
ENSG00000246695 E020 2.1538162 0.008414222 6.569543e-01 0.766400134 12 25954657 25954804 148 - 0.550 0.476 -0.359
ENSG00000246695 E021 3.6868326 0.005636674 1.166167e-01 0.215129599 12 25954805 25954920 116 - 0.550 0.776 0.963
ENSG00000246695 E022 16.7524585 0.003734082 1.229962e-03 0.004742295 12 25954921 25955137 217 - 1.096 1.359 0.930
ENSG00000246695 E023 17.5487061 0.001164578 9.812819e-03 0.028301019 12 25955138 25955241 104 - 1.158 1.354 0.688
ENSG00000246695 E024 0.9598804 0.014180892 1.058151e-01 0.199330030 12 25955242 25956226 985 - 0.414 0.125 -2.261
ENSG00000246695 E025 17.3600691 0.001203144 6.013872e-02 0.126842279 12 25956227 25956347 121 - 1.186 1.327 0.497
ENSG00000246695 E026 0.0000000       12 25956348 25956638 291 -      
ENSG00000246695 E027 17.0800464 0.001102256 5.595290e-01 0.687626733 12 25956639 25956761 123 - 1.237 1.277 0.141
ENSG00000246695 E028 3.0977995 0.005166682 4.260855e-01 0.568955933 12 25956762 25956764 3 - 0.550 0.668 0.518
ENSG00000246695 E029 1.5070818 0.009512279 2.789367e-01 0.418618223 12 25957453 25957585 133 - 0.291 0.476 1.059
ENSG00000246695 E030 0.5901394 0.386267336 6.086610e-01 0.728328743 12 25957876 25958018 143 - 0.120 0.229 1.126
ENSG00000246695 E031 16.3180831 0.001203144 9.828964e-05 0.000513929 12 25958019 25958578 560 - 1.385 1.065 -1.132
ENSG00000246695 E032 1.3618961 0.010283030 1.324184e-01 0.237442053 12 25958932 25959325 394 - 0.214 0.476 1.644
ENSG00000246695 E033 0.4438354 0.038458563 5.490118e-01 0.678787880 12 25959326 25959765 440 - 0.120 0.220 1.053