ENSG00000246596

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000499314 ENSG00000246596 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 2.404621 0.8292692 2.71709 0.1315837 0.1210785 1.700157 0.16746252 0.00000000 0.0000000 0.00000000 0.00000000 0.000000 0.05921250 0.00000000 0.00000000 0.00000000   0.03437981 FALSE  
MSTRG.27398.1 ENSG00000246596 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   2.404621 0.8292692 2.71709 0.1315837 0.1210785 1.700157 1.85648349 0.71415502 2.0236436 0.09547602 0.07169051 1.489696 0.80077500 0.87173333 0.74990000 -0.12183333 0.50357562 0.03437981 FALSE  
MSTRG.27398.2 ENSG00000246596 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   2.404621 0.8292692 2.71709 0.1315837 0.1210785 1.700157 0.07692522 0.00000000 0.1950575 0.00000000 0.03449684 4.357957 0.03139583 0.00000000 0.07096667 0.07096667 0.03437981 0.03437981 FALSE  
MSTRG.27398.5 ENSG00000246596 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   2.404621 0.8292692 2.71709 0.1315837 0.1210785 1.700157 0.21741502 0.06292222 0.3553978 0.01872566 0.03992979 2.325038 0.07766667 0.07463333 0.13073333 0.05610000 0.64979299 0.03437981 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000246596 E001 15.477140 0.0157128932 0.018104260 0.047355890 5 177618096 177618378 283 - 1.095 1.331 0.839
ENSG00000246596 E002 11.710533 0.0016009071 0.006891398 0.020942152 5 177618379 177618602 224 - 0.968 1.233 0.959
ENSG00000246596 E003 12.021169 0.0025592140 0.345099400 0.489182194 5 177618603 177618706 104 - 1.044 1.143 0.358
ENSG00000246596 E004 8.925226 0.0281504047 0.120965868 0.221320399 5 177618707 177618735 29 - 0.876 1.094 0.810
ENSG00000246596 E005 24.533010 0.0009693776 0.158415342 0.273013766 5 177618736 177619058 323 - 1.333 1.437 0.359
ENSG00000246596 E006 7.667461 0.0032609877 0.095460742 0.183568715 5 177619059 177619077 19 - 0.827 1.028 0.758
ENSG00000246596 E007 27.236023 0.0008176305 0.756269620 0.841366939 5 177619078 177619389 312 - 1.403 1.428 0.087
ENSG00000246596 E008 10.296407 0.0086143003 0.328677192 0.472151805 5 177620473 177620506 34 - 1.044 0.931 -0.417
ENSG00000246596 E009 4.967631 0.0347507150 0.338507548 0.482381468 5 177621422 177621487 66 - 0.787 0.627 -0.664
ENSG00000246596 E010 14.277917 0.0014101822 0.410821016 0.554400584 5 177626436 177626505 70 - 1.165 1.089 -0.271
ENSG00000246596 E011 21.537075 0.0008792474 0.304246065 0.446256614 5 177627382 177627614 233 - 1.337 1.260 -0.270
ENSG00000246596 E012 31.549744 0.0006696254 0.190889906 0.314854167 5 177631366 177632074 709 - 1.499 1.419 -0.277
ENSG00000246596 E013 27.653147 0.0008129623 0.002194101 0.007823622 5 177632075 177632738 664 - 1.480 1.260 -0.765
ENSG00000246596 E014 0.000000       5 177644649 177644745 97 -      
ENSG00000246596 E015 10.222678 0.0017473179 0.016566520 0.043986454 5 177672021 177672295 275 - 1.088 0.804 -1.067