ENSG00000245910

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000520944 ENSG00000245910 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 113.1545 120.4896 128.9964 14.26682 1.755735 0.09841494 53.652432 60.305163 63.45607 6.6209692 1.0784229 0.07346476 0.47090833 0.50153333 0.49200000 -0.009533333 0.86159189 0.03693637    
ENST00000521127 ENSG00000245910 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA retained_intron 113.1545 120.4896 128.9964 14.26682 1.755735 0.09841494 9.524409 6.284714 11.60925 1.3902059 1.0068799 0.88430398 0.08667917 0.05246667 0.08983333 0.037366667 0.15929826 0.03693637    
ENST00000521399 ENSG00000245910 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 113.1545 120.4896 128.9964 14.26682 1.755735 0.09841494 32.896104 40.592695 33.11076 6.1118802 1.2011365 -0.29383973 0.28782083 0.33500000 0.25680000 -0.078200000 0.03693637 0.03693637    
ENST00000689720 ENSG00000245910 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 113.1545 120.4896 128.9964 14.26682 1.755735 0.09841494 10.905533 8.714813 13.29342 0.9534967 0.8057654 0.60860084 0.09896667 0.07343333 0.10296667 0.029533333 0.16796753 0.03693637    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000245910 E001 9.415050 0.0018101797 1.411673e-03 5.345429e-03 8 66920561 66921817 1257 - 1.177 0.846 -1.224
ENSG00000245910 E002 3.981524 0.0039165959 3.346751e-02 7.871382e-02 8 66921818 66921926 109 - 0.846 0.548 -1.250
ENSG00000245910 E003 2.737729 0.0092974101 4.381317e-02 9.804812e-02 8 66921927 66921933 7 - 0.728 0.412 -1.460
ENSG00000245910 E004 72.725351 0.0101988879 5.613954e-01 6.892184e-01 8 66921934 66921985 52 - 1.845 1.893 0.162
ENSG00000245910 E005 212.302446 0.0005845743 8.692009e-01 9.199558e-01 8 66921986 66922017 32 - 2.329 2.339 0.034
ENSG00000245910 E006 783.532751 0.0001592965 5.634284e-02 1.203251e-01 8 66922018 66922114 97 - 2.882 2.909 0.092
ENSG00000245910 E007 101.434248 0.0061680420 2.856988e-03 9.844987e-03 8 66922115 66922270 156 - 2.088 1.931 -0.526
ENSG00000245910 E008 60.457892 0.0026549955 2.415649e-06 1.845835e-05 8 66922271 66922323 53 - 1.903 1.665 -0.803
ENSG00000245910 E009 751.092464 0.0001833730 8.539841e-01 9.096515e-01 8 66922324 66922385 62 - 2.878 2.880 0.007
ENSG00000245910 E010 470.879458 0.0001651490 7.412332e-01 8.304763e-01 8 66922386 66922392 7 - 2.677 2.676 -0.002
ENSG00000245910 E011 62.336906 0.0218835817 8.929667e-03 2.610283e-02 8 66922393 66922466 74 - 1.910 1.684 -0.763
ENSG00000245910 E012 70.230971 0.0203635877 1.100108e-02 3.116444e-02 8 66922467 66922613 147 - 1.951 1.749 -0.682
ENSG00000245910 E013 775.801542 0.0001818015 5.650887e-01 6.922453e-01 8 66922614 66922725 112 - 2.886 2.896 0.036
ENSG00000245910 E014 585.941702 0.0053811564 2.242518e-02 5.656140e-02 8 66925437 66925597 161 - 2.724 2.798 0.247
ENSG00000245910 E015 18.408573 0.0235521515 1.960039e-01 3.212197e-01 8 66926198 66926398 201 - 1.357 1.218 -0.486