ENSG00000245904

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000499685 ENSG00000245904 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.254816 0.3646342 0.1313535 0.2223059 0.04893742 -1.406175 0.01131090 0.002464189 0.01720218 0.002464189 0.001923333 1.1259331 0.08358261 0.003033333 0.2092000 0.2061667 0.163000768 0.001327543   FALSE
ENST00000501008 ENSG00000245904 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.254816 0.3646342 0.1313535 0.2223059 0.04893742 -1.406175 0.01129671 0.000000000 0.00000000 0.000000000 0.000000000 0.0000000 0.05846087 0.000000000 0.0000000 0.0000000   0.001327543   FALSE
ENST00000618125 ENSG00000245904 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.254816 0.3646342 0.1313535 0.2223059 0.04893742 -1.406175 0.04642937 0.024981270 0.00000000 0.024981270 0.000000000 -1.8065827 0.13226087 0.152766667 0.0000000 -0.1527667 0.914577882 0.001327543   FALSE
ENST00000654992 ENSG00000245904 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.254816 0.3646342 0.1313535 0.2223059 0.04893742 -1.406175 0.01292100 0.000000000 0.01711851 0.000000000 0.009280777 1.4392781 0.10293913 0.000000000 0.2534333 0.2534333 0.380802098 0.001327543   FALSE
ENST00000685108 ENSG00000245904 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.254816 0.3646342 0.1313535 0.2223059 0.04893742 -1.406175 0.10308550 0.284041731 0.00000000 0.179115896 0.000000000 -4.8779490 0.34679565 0.778466667 0.0000000 -0.7784667 0.001327543 0.001327543 FALSE FALSE
ENST00000687274 ENSG00000245904 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.254816 0.3646342 0.1313535 0.2223059 0.04893742 -1.406175 0.02664482 0.000000000 0.05420361 0.000000000 0.054203611 2.6826544 0.09476957 0.000000000 0.2956667 0.2956667 0.688228453 0.001327543   FALSE
ENST00000691470 ENSG00000245904 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.254816 0.3646342 0.1313535 0.2223059 0.04893742 -1.406175 0.03134600 0.053147013 0.04282925 0.053147013 0.042829245 -0.2573777 0.12552609 0.065733333 0.2417000 0.1759667 0.876156722 0.001327543   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000245904 E001 0.2214452 0.04134604 0.42795277   12 92145573 92146082 510 + 0.000 0.123 10.498
ENSG00000245904 E002 0.0000000       12 92146083 92146132 50 +      
ENSG00000245904 E003 0.0000000       12 92146133 92146156 24 +      
ENSG00000245904 E004 0.0000000       12 92146157 92146158 2 +      
ENSG00000245904 E005 0.0000000       12 92146159 92146159 1 +      
ENSG00000245904 E006 0.0000000       12 92146160 92146180 21 +      
ENSG00000245904 E007 0.0000000       12 92146181 92146181 1 +      
ENSG00000245904 E008 0.0000000       12 92146182 92146182 1 +      
ENSG00000245904 E009 0.0000000       12 92146183 92146183 1 +      
ENSG00000245904 E010 0.0000000       12 92146184 92146193 10 +      
ENSG00000245904 E011 0.1482932 0.35859047 0.45219047   12 92146194 92146201 8 + 0.000 0.120 12.400
ENSG00000245904 E012 1.2274342 0.01612861 0.54627743 0.67648445 12 92146202 92146243 42 + 0.296 0.363 0.421
ENSG00000245904 E013 0.1515154 0.05600558 0.56538469   12 92146244 92146254 11 + 0.122 0.000 -12.798
ENSG00000245904 E014 0.1515154 0.05600558 0.56538469   12 92146255 92146364 110 + 0.122 0.000 -12.798
ENSG00000245904 E015 0.5244761 0.02662782 0.65994411 0.76868102 12 92146365 92146446 82 + 0.218 0.123 -0.994
ENSG00000245904 E016 0.8878717 0.01565897 0.54061666 0.67172997 12 92146447 92146661 215 + 0.217 0.296 0.591
ENSG00000245904 E017 2.3240657 0.00840988 0.21705901 0.34683855 12 92146662 92146762 101 + 0.419 0.558 0.685
ENSG00000245904 E018 0.7697675 0.02029646 0.24770940 0.38324679 12 92146763 92146982 220 + 0.122 0.297 1.594
ENSG00000245904 E019 0.0000000       12 92149297 92149562 266 +      
ENSG00000245904 E020 0.0000000       12 92167119 92167560 442 +      
ENSG00000245904 E021 1.3996649 0.02138209 0.01294038 0.03577186 12 92184126 92189660 5535 + 0.556 0.123 -2.993
ENSG00000245904 E022 0.1515154 0.05600558 0.56538469   12 92213833 92214100 268 + 0.122 0.000 -12.798
ENSG00000245904 E023 0.1472490 0.81716960 0.62025583   12 92224788 92226557 1770 + 0.122 0.000 -12.731