ENSG00000245532

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000612303 ENSG00000245532 HEK293_OSMI2_2hA HEK293_TMG_2hB NEAT1 lncRNA lncRNA 12.30203 3.934125 12.83303 0.7870932 1.162411 1.703208 2.161582 0.1150689 2.296647 0.1150689 0.1198460 4.2050020 0.1534042 0.0449000 0.1816667 0.1367667 1.502975e-01 1.670288e-13   FALSE
ENST00000613347 ENSG00000245532 HEK293_OSMI2_2hA HEK293_TMG_2hB NEAT1 lncRNA misc_RNA 12.30203 3.934125 12.83303 0.7870932 1.162411 1.703208 3.092416 1.5912363 3.271762 0.2473156 0.5125760 1.0352844 0.2953250 0.4135000 0.2526000 -0.1609000 1.134646e-02 1.670288e-13   FALSE
ENST00000620348 ENSG00000245532 HEK293_OSMI2_2hA HEK293_TMG_2hB NEAT1 lncRNA misc_RNA 12.30203 3.934125 12.83303 0.7870932 1.162411 1.703208 1.489635 1.0711528 1.389888 0.5412287 0.8105325 0.3727415 0.1178083 0.2339333 0.1005333 -0.1334000 8.567068e-01 1.670288e-13   FALSE
ENST00000620525 ENSG00000245532 HEK293_OSMI2_2hA HEK293_TMG_2hB NEAT1 lncRNA misc_RNA 12.30203 3.934125 12.83303 0.7870932 1.162411 1.703208 3.401675 0.0000000 3.830451 0.0000000 0.3580159 8.5851318 0.2301417 0.0000000 0.3050333 0.3050333 1.670288e-13 1.670288e-13   FALSE
ENST00000685861 ENSG00000245532 HEK293_OSMI2_2hA HEK293_TMG_2hB NEAT1 lncRNA lncRNA 12.30203 3.934125 12.83303 0.7870932 1.162411 1.703208 1.723061 1.0572022 1.895676 0.1532079 0.1484878 0.8364694 0.1735708 0.2812000 0.1481667 -0.1330333 1.740807e-02 1.670288e-13 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000245532 E001 0.000000       11 65422774 65422796 23 +      
ENSG00000245532 E002 0.000000       11 65422797 65422797 1 +      
ENSG00000245532 E003 0.000000       11 65422798 65422799 2 +      
ENSG00000245532 E004 0.000000       11 65422800 65422803 4 +      
ENSG00000245532 E005 16.119996 0.0011217585 7.001685e-02 1.433998e-01 11 65422804 65422969 166 + 1.277 1.123 -0.544
ENSG00000245532 E006 28.169710 0.0007024302 1.028355e-02 2.946441e-02 11 65422970 65423095 126 + 1.511 1.341 -0.585
ENSG00000245532 E007 17.177908 0.0010611182 2.404906e-02 5.991455e-02 11 65423096 65423113 18 + 1.313 1.123 -0.670
ENSG00000245532 E008 17.262815 0.0010163782 1.356116e-02 3.721637e-02 11 65423114 65423124 11 + 1.318 1.108 -0.741
ENSG00000245532 E009 27.318236 0.0007222500 3.097172e-01 4.520614e-01 11 65423125 65423212 88 + 1.461 1.400 -0.211
ENSG00000245532 E010 15.686625 0.0012015341 5.327120e-01 6.650282e-01 11 65423213 65423219 7 + 1.226 1.179 -0.165
ENSG00000245532 E011 19.167694 0.0010725876 2.907406e-01 4.315382e-01 11 65423220 65423272 53 + 1.318 1.240 -0.271
ENSG00000245532 E012 15.246559 0.0011967546 8.672022e-01 9.185897e-01 11 65423273 65423294 22 + 1.182 1.205 0.083
ENSG00000245532 E013 22.641192 0.0038522408 4.667716e-01 6.063172e-01 11 65423295 65423383 89 + 1.327 1.393 0.230
ENSG00000245532 E014 29.556887 0.0006629442 2.718014e-02 6.635903e-02 11 65423384 65423538 155 + 1.517 1.376 -0.486
ENSG00000245532 E015 35.778606 0.0078467722 6.271406e-03 1.932371e-02 11 65423539 65423626 88 + 1.613 1.418 -0.667
ENSG00000245532 E016 22.992785 0.0024814164 1.729494e-02 4.559567e-02 11 65423627 65423637 11 + 1.421 1.241 -0.627
ENSG00000245532 E017 25.600771 0.0043896451 7.707061e-03 2.304346e-02 11 65423638 65423657 20 + 1.475 1.274 -0.697
ENSG00000245532 E018 25.688722 0.0009156354 3.124401e-02 7.437625e-02 11 65423658 65423678 21 + 1.461 1.313 -0.512
ENSG00000245532 E019 61.978893 0.0006802353 1.456382e-04 7.284103e-04 11 65423679 65423959 281 + 1.841 1.668 -0.587
ENSG00000245532 E020 20.010566 0.0091587720 5.514897e-01 6.809406e-01 11 65423960 65423962 3 + 1.323 1.275 -0.167
ENSG00000245532 E021 230.284857 0.0003243903 1.494623e-02 4.036492e-02 11 65423963 65425413 1451 + 2.365 2.320 -0.152
ENSG00000245532 E022 62.122846 0.0004511939 1.545101e-02 4.151535e-02 11 65425414 65425550 137 + 1.733 1.849 0.394
ENSG00000245532 E023 65.012056 0.0004982257 1.433927e-03 5.419945e-03 11 65425551 65425737 187 + 1.737 1.884 0.499
ENSG00000245532 E024 76.479323 0.0004702209 1.976066e-08 2.306734e-07 11 65425738 65426060 323 + 1.767 1.999 0.782
ENSG00000245532 E025 85.540163 0.0087472322 3.886540e-05 2.246989e-04 11 65426061 65431819 5759 + 1.818 2.056 0.799
ENSG00000245532 E026 12.582237 0.0070443786 1.100002e-01 2.055391e-01 11 65431820 65440181 8362 + 1.051 1.217 0.594
ENSG00000245532 E027 9.698619 0.0025501524 1.329160e-08 1.601204e-07 11 65440182 65444457 4276 + 0.674 1.294 2.325
ENSG00000245532 E028 4.640254 0.0117355217 5.977591e-04 2.525449e-03 11 65444458 65445540 1083 + 0.491 0.984 2.043