ENSG00000244879

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000499624 ENSG00000244879 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 4.539833 3.775841 4.026419 0.2999529 0.1138743 0.09246218 0.91643730 0.23603464 1.35462433 0.01142745 0.07397995 2.4715705 0.19621250 0.06340000 0.33610000 0.272700000 1.058496e-11 1.058496e-11 FALSE FALSE
ENST00000558593 ENSG00000244879 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 4.539833 3.775841 4.026419 0.2999529 0.1138743 0.09246218 0.26332807 0.08451219 0.05115253 0.08451219 0.05115253 -0.6280881 0.05505000 0.02033333 0.01256667 -0.007766667 9.961270e-01 1.058496e-11   FALSE
ENST00000560359 ENSG00000244879 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 4.539833 3.775841 4.026419 0.2999529 0.1138743 0.09246218 0.34330370 0.31405608 0.44398690 0.31405608 0.22543827 0.4864072 0.07001667 0.09860000 0.11166667 0.013066667 6.612846e-01 1.058496e-11   FALSE
ENST00000583750 ENSG00000244879 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA miRNA 4.539833 3.775841 4.026419 0.2999529 0.1138743 0.09246218 0.04369525 0.00000000 0.23773557 0.00000000 0.11892409 4.6307291 0.00993750 0.00000000 0.05753333 0.057533333 1.850278e-01 1.058496e-11   FALSE
ENST00000619314 ENSG00000244879 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 4.539833 3.775841 4.026419 0.2999529 0.1138743 0.09246218 0.89848015 0.43275305 0.22698237 0.43275305 0.22698237 -0.9017225 0.19248333 0.10403333 0.05576667 -0.048266667 1.000000e+00 1.058496e-11   FALSE
ENST00000687003 ENSG00000244879 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 4.539833 3.775841 4.026419 0.2999529 0.1138743 0.09246218 0.62646889 1.00020471 0.82293562 0.50444628 0.41719527 -0.2783708 0.17460417 0.28496667 0.20500000 -0.079966667 9.563429e-01 1.058496e-11 FALSE FALSE
ENST00000689965 ENSG00000244879 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 4.539833 3.775841 4.026419 0.2999529 0.1138743 0.09246218 0.57158779 1.07203509 0.33101957 0.54397917 0.33101957 -1.6658208 0.11992917 0.26286667 0.08133333 -0.181533333 4.965675e-01 1.058496e-11   FALSE
MSTRG.10791.1 ENSG00000244879 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   4.539833 3.775841 4.026419 0.2999529 0.1138743 0.09246218 0.15470247 0.35041576 0.00000000 0.08425640 0.00000000 -5.1715902 0.03779583 0.09023333 0.00000000 -0.090233333 4.498758e-07 1.058496e-11 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000244879 E001 1.725393 0.0299032073 1.400869e-01 2.481486e-01 15 50354950 50354958 9 + 0.313 0.534 1.197
ENSG00000244879 E002 1.725393 0.0299032073 1.400869e-01 2.481486e-01 15 50354959 50354964 6 + 0.313 0.534 1.197
ENSG00000244879 E003 1.731736 0.0087507515 1.275542e-01 2.307427e-01 15 50354965 50354970 6 + 0.313 0.533 1.193
ENSG00000244879 E004 16.149332 0.0011342962 7.446016e-07 6.359038e-06 15 50354971 50355248 278 + 1.042 1.392 1.241
ENSG00000244879 E005 11.496454 0.0115339016 2.048930e-05 1.267970e-04 15 50355249 50355327 79 + 0.881 1.278 1.446
ENSG00000244879 E006 13.583166 0.0013508828 2.597841e-08 2.962636e-07 15 50355328 50355459 132 + 0.910 1.356 1.606
ENSG00000244879 E007 4.980119 0.0034630386 1.417884e-02 3.863114e-02 15 50355460 50355465 6 + 0.620 0.894 1.110
ENSG00000244879 E008 4.980119 0.0034630386 1.417884e-02 3.863114e-02 15 50355466 50355466 1 + 0.620 0.894 1.110
ENSG00000244879 E009 4.832870 0.0038691563 8.603258e-03 2.529623e-02 15 50355467 50355467 1 + 0.591 0.894 1.236
ENSG00000244879 E010 5.202609 0.0036418178 2.655906e-03 9.240949e-03 15 50355468 50355475 8 + 0.591 0.936 1.396
ENSG00000244879 E011 6.521629 0.0048419524 1.326207e-04 6.703467e-04 15 50355476 50355492 17 + 0.620 1.044 1.668
ENSG00000244879 E012 18.920352 0.0009941014 4.103053e-09 5.428150e-08 15 50355493 50355544 52 + 1.072 1.470 1.399
ENSG00000244879 E013 15.999804 0.0012189530 4.942364e-08 5.333311e-07 15 50355545 50355545 1 + 1.010 1.406 1.407
ENSG00000244879 E014 10.160110 0.0017970902 3.720705e-10 5.964430e-09 15 50355546 50355552 7 + 0.671 1.280 2.291
ENSG00000244879 E015 32.681020 0.0006557233 1.632558e-13 4.507189e-12 15 50355553 50355765 213 + 1.312 1.692 1.304
ENSG00000244879 E016 7.765617 0.0032074278 5.137349e-03 1.630216e-02 15 50355766 50355783 18 + 0.816 1.073 0.967
ENSG00000244879 E017 6.857771 0.0025413592 1.300933e-03 4.979650e-03 15 50355784 50355788 5 + 0.718 1.043 1.250
ENSG00000244879 E018 17.193672 0.0011788864 3.974409e-10 6.341080e-09 15 50355789 50355932 144 + 0.999 1.452 1.606
ENSG00000244879 E019 17.759331 0.0020413932 9.443165e-16 3.577243e-14 15 50355933 50356099 167 + 0.895 1.514 2.208
ENSG00000244879 E020 31.571476 0.0082935270 1.075223e-06 8.863363e-06 15 50356100 50356257 158 + 1.365 1.655 0.996
ENSG00000244879 E021 10.999177 0.0112553638 1.284847e-03 4.926338e-03 15 50356258 50356307 50 + 0.937 1.220 1.026
ENSG00000244879 E022 9.002839 0.0228207648 6.637145e-01 7.717109e-01 15 50356308 50356470 163 + 1.053 0.933 -0.443
ENSG00000244879 E023 22.110704 0.0008923256 3.249034e-11 6.219885e-10 15 50356471 50356918 448 + 1.541 0.894 -2.306
ENSG00000244879 E024 70.276861 0.0104631362 3.329684e-11 6.363990e-10 15 50356919 50360328 3410 + 2.004 1.498 -1.714
ENSG00000244879 E025 44.574559 0.0005039590 5.881298e-16 2.291638e-14 15 50360329 50361963 1635 + 1.822 1.271 -1.889
ENSG00000244879 E026 8.544410 0.0019722598 3.140513e-04 1.436964e-03 15 50361964 50362081 118 + 1.135 0.625 -1.979
ENSG00000244879 E027 100.651046 0.0232166898 3.908723e-12 8.700456e-11 15 50362082 50367380 5299 + 2.179 1.565 -2.070
ENSG00000244879 E028 66.656879 0.0005133616 4.348661e-08 4.748362e-07 15 50367381 50370329 2949 + 1.939 1.627 -1.056
ENSG00000244879 E029 1.371464 0.0095045872 3.783836e-01 5.226698e-01 15 50370330 50370331 2 + 0.454 0.256 -1.202
ENSG00000244879 E030 48.676887 0.0055121458 7.588180e-01 8.433298e-01 15 50370332 50372202 1871 + 1.717 1.671 -0.155