ENSG00000243701

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000466734 ENSG00000243701 HEK293_OSMI2_2hA HEK293_TMG_2hB DUBR lncRNA lncRNA 2.504696 1.484221 2.778001 0.2541089 0.08459506 0.8998371 0.62386286 0.26206062 0.6002180 0.13106188 0.2257953 1.1653965 0.228400000 0.16553333 0.22103333 0.05550000 0.83539763 0.04247537   FALSE
ENST00000660597 ENSG00000243701 HEK293_OSMI2_2hA HEK293_TMG_2hB DUBR lncRNA lncRNA 2.504696 1.484221 2.778001 0.2541089 0.08459506 0.8998371 0.44242352 0.28548293 0.4600442 0.05349813 0.0178637 0.6697217 0.187370833 0.21060000 0.16633333 -0.04426667 0.81704273 0.04247537 FALSE FALSE
ENST00000662418 ENSG00000243701 HEK293_OSMI2_2hA HEK293_TMG_2hB DUBR lncRNA lncRNA 2.504696 1.484221 2.778001 0.2541089 0.08459506 0.8998371 0.28133015 0.29667928 0.4206764 0.06337150 0.2131784 0.4898737 0.112145833 0.21326667 0.14806667 -0.06520000 0.77987127 0.04247537 FALSE FALSE
ENST00000667442 ENSG00000243701 HEK293_OSMI2_2hA HEK293_TMG_2hB DUBR lncRNA lncRNA 2.504696 1.484221 2.778001 0.2541089 0.08459506 0.8998371 0.32144917 0.26918841 0.4159525 0.26918841 0.2084121 0.6094535 0.114912500 0.13563333 0.14590000 0.01026667 0.75303155 0.04247537 FALSE FALSE
ENST00000667603 ENSG00000243701 HEK293_OSMI2_2hA HEK293_TMG_2hB DUBR lncRNA lncRNA 2.504696 1.484221 2.778001 0.2541089 0.08459506 0.8998371 0.01585009 0.09268134 0.0000000 0.04637513 0.0000000 -3.3601022 0.009504167 0.06376667 0.00000000 -0.06376667 0.04247537 0.04247537 FALSE FALSE
ENST00000667634 ENSG00000243701 HEK293_OSMI2_2hA HEK293_TMG_2hB DUBR lncRNA lncRNA 2.504696 1.484221 2.778001 0.2541089 0.08459506 0.8998371 0.19594775 0.03985708 0.1407645 0.03985708 0.1407645 1.5964269 0.078866667 0.03040000 0.05073333 0.02033333 0.96468519 0.04247537   FALSE
ENST00000669723 ENSG00000243701 HEK293_OSMI2_2hA HEK293_TMG_2hB DUBR lncRNA lncRNA 2.504696 1.484221 2.778001 0.2541089 0.08459506 0.8998371 0.06744607 0.00000000 0.3484216 0.00000000 0.1763847 5.1635855 0.023770833 0.00000000 0.12630000 0.12630000 0.28746516 0.04247537 TRUE FALSE
ENST00000670833 ENSG00000243701 HEK293_OSMI2_2hA HEK293_TMG_2hB DUBR lncRNA lncRNA 2.504696 1.484221 2.778001 0.2541089 0.08459506 0.8998371 0.06695823 0.10858669 0.0000000 0.10858669 0.0000000 -3.5678701 0.037545833 0.08283333 0.00000000 -0.08283333 0.67395297 0.04247537 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000243701 E001 0.0000000       3 107220744 107220841 98 +      
ENSG00000243701 E002 0.0000000       3 107230868 107231090 223 +      
ENSG00000243701 E003 0.0000000       3 107240664 107240674 11 +      
ENSG00000243701 E004 0.0000000       3 107240675 107240684 10 +      
ENSG00000243701 E005 0.0000000       3 107240685 107240689 5 +      
ENSG00000243701 E006 0.0000000       3 107240690 107240691 2 +      
ENSG00000243701 E007 0.0000000       3 107240692 107240695 4 +      
ENSG00000243701 E008 0.7352129 0.1281920005 3.899572e-01 0.5339883257 3 107240696 107240707 12 + 0.314 0.145 -1.416
ENSG00000243701 E009 1.2103832 0.0348767436 8.934810e-01 0.9358971936 3 107240708 107240711 4 + 0.366 0.341 -0.148
ENSG00000243701 E010 1.2103832 0.0348767436 8.934810e-01 0.9358971936 3 107240712 107240714 3 + 0.366 0.341 -0.148
ENSG00000243701 E011 1.2103832 0.0348767436 8.934810e-01 0.9358971936 3 107240715 107240717 3 + 0.366 0.341 -0.148
ENSG00000243701 E012 1.2103832 0.0348767436 8.934810e-01 0.9358971936 3 107240718 107240719 2 + 0.366 0.341 -0.148
ENSG00000243701 E013 1.2103832 0.0348767436 8.934810e-01 0.9358971936 3 107240720 107240720 1 + 0.366 0.341 -0.148
ENSG00000243701 E014 1.7273706 0.0534224124 7.308502e-01 0.8226537107 3 107240721 107240726 6 + 0.413 0.476 0.325
ENSG00000243701 E015 11.2991221 0.0017723827 2.618016e-02 0.0643154901 3 107240727 107240833 107 + 0.977 1.187 0.763
ENSG00000243701 E016 15.8528128 0.0013200154 3.710155e-02 0.0856656119 3 107240834 107240956 123 + 1.137 1.305 0.594
ENSG00000243701 E017 13.1195574 0.0022992633 4.560654e-01 0.5965341475 3 107240957 107241087 131 + 1.111 1.176 0.232
ENSG00000243701 E018 0.9350151 0.0196591049 2.302719e-01 0.3627863007 3 107241088 107241787 700 + 0.367 0.146 -1.729
ENSG00000243701 E019 0.6717251 0.0212537969 5.454449e-01 0.6757848073 3 107245138 107245218 81 + 0.254 0.146 -0.990
ENSG00000243701 E020 1.2576127 0.0103599274 3.838578e-01 0.5280646250 3 107245219 107245607 389 + 0.413 0.255 -0.992
ENSG00000243701 E021 5.4940825 0.0030926174 1.271021e-02 0.0352311941 3 107246008 107246052 45 + 0.925 0.580 -1.406
ENSG00000243701 E022 7.9900892 0.0028892320 1.248188e-01 0.2268645915 3 107246053 107246137 85 + 1.023 0.845 -0.670
ENSG00000243701 E023 8.5843948 0.0108347971 3.021947e-01 0.4440419634 3 107246138 107246209 72 + 1.033 0.913 -0.449
ENSG00000243701 E024 34.3014847 0.0007438189 4.494952e-01 0.5906932226 3 107246210 107246994 785 + 1.562 1.518 -0.151
ENSG00000243701 E025 7.0974340 0.0027296668 9.728906e-01 0.9870835585 3 107246995 107247063 69 + 0.911 0.913 0.007
ENSG00000243701 E026 6.0666563 0.0030389172 1.332025e-01 0.2385877213 3 107247064 107247088 25 + 0.925 0.732 -0.756
ENSG00000243701 E027 20.6658779 0.0053067715 7.685278e-01 0.8504141926 3 107247089 107247949 861 + 1.341 1.314 -0.095
ENSG00000243701 E028 15.3594375 0.0026052384 2.320156e-01 0.3648355808 3 107247950 107248542 593 + 1.162 1.260 0.347
ENSG00000243701 E029 4.2299345 0.1915738415 6.017004e-01 0.7228016866 3 107248543 107248577 35 + 0.671 0.781 0.449
ENSG00000243701 E030 8.2294276 0.0028289444 9.302856e-01 0.9601419160 3 107248578 107248831 254 + 0.964 0.973 0.030
ENSG00000243701 E031 16.4884050 0.0013508828 8.954836e-01 0.9372243952 3 107248832 107251102 2271 + 1.241 1.250 0.030
ENSG00000243701 E032 2.1057461 0.0067802922 3.819245e-02 0.0877140658 3 107251543 107251773 231 + 0.621 0.255 -1.992
ENSG00000243701 E033 0.6621601 0.0178069273 6.819189e-01 0.7855109467 3 107266820 107266967 148 + 0.185 0.255 0.593
ENSG00000243701 E034 0.0000000       3 107283193 107283376 184 +      
ENSG00000243701 E035 0.0000000       3 107285295 107285319 25 +      
ENSG00000243701 E036 2.8742739 0.0058200292 7.879828e-05 0.0004222941 3 107285320 107285531 212 + 0.185 0.819 3.401
ENSG00000243701 E037 0.6652806 0.0178406548 1.578294e-01 0.2722317753 3 107285532 107286014 483 + 0.102 0.342 2.177
ENSG00000243701 E038 0.1515154 0.0426482082 7.166035e-01   3 107286015 107286177 163 + 0.102 0.000 -10.572
ENSG00000243701 E039 0.0000000       3 107286178 107286585 408 +      
ENSG00000243701 E040 0.2987644 0.0272759922 3.408637e-01   3 107291762 107291930 169 + 0.185 0.000 -11.461
ENSG00000243701 E041 1.3445089 0.2511762744 4.080799e-01 0.5516598034 3 107291931 107294633 2703 + 0.457 0.250 -1.257
ENSG00000243701 E042 0.1515154 0.0426482082 7.166035e-01   3 107294634 107294990 357 + 0.102 0.000 -10.572
ENSG00000243701 E043 0.0000000       3 107325607 107325691 85 +      
ENSG00000243701 E044 0.5975289 0.0245118297 9.106396e-02 0.1768055860 3 107326466 107326964 499 + 0.314 0.000 -12.265
ENSG00000243701 E045 0.1515154 0.0426482082 7.166035e-01   3 107345820 107348464 2645 + 0.102 0.000 -10.572