ENSG00000243660

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000315429 ENSG00000243660 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF487 protein_coding protein_coding 1.540091 1.716985 1.656328 0.3949299 0.5022855 -0.05158308 0.16413434 0.10766598 0.1583911 0.10766598 0.08517533 0.5171190 0.09485417 0.04986667 0.09466667 0.044800000 0.735125549 0.001812013 FALSE FALSE
ENST00000437590 ENSG00000243660 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF487 protein_coding protein_coding 1.540091 1.716985 1.656328 0.3949299 0.5022855 -0.05158308 0.28991241 0.15540179 0.4395950 0.08033577 0.03248523 1.4426510 0.20117500 0.07390000 0.32570000 0.251800000 0.150776153 0.001812013 FALSE TRUE
ENST00000451167 ENSG00000243660 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF487 protein_coding protein_coding 1.540091 1.716985 1.656328 0.3949299 0.5022855 -0.05158308 0.06393343 0.00000000 0.3413399 0.00000000 0.34133989 5.1347955 0.02952083 0.00000000 0.12950000 0.129500000 0.772597504 0.001812013   FALSE
ENST00000490208 ENSG00000243660 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF487 protein_coding processed_transcript 1.540091 1.716985 1.656328 0.3949299 0.5022855 -0.05158308 0.75622264 1.30310079 0.5335199 0.30638523 0.07111130 -1.2725730 0.50214167 0.76050000 0.35830000 -0.402200000 0.001812013 0.001812013   FALSE
ENST00000689627 ENSG00000243660 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF487 protein_coding protein_coding 1.540091 1.716985 1.656328 0.3949299 0.5022855 -0.05158308 0.13008847 0.09306639 0.1606493 0.05511172 0.10579585 0.7274602 0.07810833 0.08210000 0.07536667 -0.006733333 0.939054571 0.001812013 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000243660 E001 0.2214452 0.037809928 4.688573e-01   10 43436841 43436847 7 + 0.000 0.127 9.972
ENSG00000243660 E002 0.3686942 0.026943289 9.727659e-01 9.870160e-01 10 43436848 43436872 25 + 0.118 0.127 0.115
ENSG00000243660 E003 2.5369807 0.007421833 4.904071e-01 6.277485e-01 10 43436873 43436935 63 + 0.582 0.482 -0.470
ENSG00000243660 E004 1.1781165 0.169146464 8.735844e-01 9.227604e-01 10 43436936 43437110 175 + 0.353 0.307 -0.283
ENSG00000243660 E005 0.7331471 0.021521754 3.323047e-02 7.825832e-02 10 43437111 43437125 15 + 0.000 0.372 13.595
ENSG00000243660 E006 1.3953073 0.010864776 1.312072e-01 2.358375e-01 10 43437126 43437147 22 + 0.211 0.482 1.698
ENSG00000243660 E007 1.6167525 0.009132097 7.463982e-02 1.509618e-01 10 43437148 43437155 8 + 0.211 0.528 1.921
ENSG00000243660 E008 0.9201370 0.013696863 1.531862e-01 2.660055e-01 10 43437156 43437157 2 + 0.118 0.372 2.114
ENSG00000243660 E009 2.2067927 0.007644898 3.536926e-01 4.979526e-01 10 43437158 43437262 105 + 0.409 0.569 0.791
ENSG00000243660 E010 0.2965864 0.166441900 2.304439e-01   10 43451920 43454064 2145 + 0.000 0.221 12.645
ENSG00000243660 E011 14.6805109 0.004059470 1.241945e-06 1.010969e-05 10 43454065 43454532 468 + 0.930 1.348 1.502
ENSG00000243660 E012 2.4314722 0.006581839 8.609532e-02 1.691452e-01 10 43454533 43454664 132 + 0.353 0.642 1.435
ENSG00000243660 E013 0.0000000       10 43475696 43475720 25 +      
ENSG00000243660 E014 3.1573011 0.007874086 1.430516e-03 5.408887e-03 10 43475721 43475830 110 + 0.801 0.305 -2.388
ENSG00000243660 E015 2.0565144 0.008130386 1.109328e-02 3.138995e-02 10 43475831 43475847 17 + 0.648 0.225 -2.345
ENSG00000243660 E016 2.5767241 0.006830844 1.176895e-02 3.298165e-02 10 43476107 43476202 96 + 0.705 0.305 -2.001
ENSG00000243660 E017 2.8117972 0.006340296 5.154779e-01 6.501540e-01 10 43481429 43481678 250 + 0.616 0.528 -0.402
ENSG00000243660 E018 1.4768798 0.010306339 6.970735e-01 7.972957e-01 10 43481679 43481731 53 + 0.353 0.430 0.433
ENSG00000243660 E019 18.9676263 0.003220097 3.105524e-04 1.422535e-03 10 43481732 43483181 1450 + 1.405 1.182 -0.782