ENSG00000242516

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000463183 ENSG00000242516 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00960 lncRNA lncRNA 0.5758447 0.8158883 0.3359193 0.03562522 0.06149654 -1.255511 0.02653795 0.03604337 0.00000000 0.03604337 0.00000000 -2.202993 0.06295833 0.04766667 0.00000000 -0.04766667 0.88767080 0.03836265 FALSE FALSE
ENST00000492922 ENSG00000242516 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00960 lncRNA lncRNA 0.5758447 0.8158883 0.3359193 0.03562522 0.06149654 -1.255511 0.07070578 0.04980952 0.07066776 0.01674684 0.01396195 0.431617 0.13312083 0.05960000 0.21196667 0.15236667 0.11858923 0.03836265   FALSE
ENST00000662338 ENSG00000242516 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00960 lncRNA lncRNA 0.5758447 0.8158883 0.3359193 0.03562522 0.06149654 -1.255511 0.01227342 0.00000000 0.03182824 0.00000000 0.03182824 2.064477 0.02635000 0.00000000 0.09620000 0.09620000 0.61054201 0.03836265 FALSE TRUE
ENST00000665741 ENSG00000242516 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00960 lncRNA lncRNA 0.5758447 0.8158883 0.3359193 0.03562522 0.06149654 -1.255511 0.13439424 0.29173401 0.08027156 0.09415799 0.08027156 -1.740934 0.22887083 0.35156667 0.18043333 -0.17113333 0.57524406 0.03836265 FALSE FALSE
ENST00000666754 ENSG00000242516 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00960 lncRNA lncRNA 0.5758447 0.8158883 0.3359193 0.03562522 0.06149654 -1.255511 0.01846684 0.00000000 0.10466169 0.00000000 0.05540170 3.519312 0.05454583 0.00000000 0.36483333 0.36483333 0.15502474 0.03836265 FALSE FALSE
ENST00000669013 ENSG00000242516 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00960 lncRNA lncRNA 0.5758447 0.8158883 0.3359193 0.03562522 0.06149654 -1.255511 0.22035285 0.36087358 0.02863719 0.04447025 0.02863719 -3.262865 0.36509583 0.44386667 0.08656667 -0.35730000 0.03836265 0.03836265 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000242516 E001 0.2965864 0.153600599 1.000000000   3 75672254 75672299 46 + 0.000 0.125 9.629
ENSG00000242516 E002 0.5180316 0.021689434 0.656180357 0.76587458 3 75672300 75672371 72 + 0.000 0.178 11.796
ENSG00000242516 E003 0.3697384 0.026110823 1.000000000 1.00000000 3 75672372 75672390 19 + 0.000 0.127 11.337
ENSG00000242516 E004 1.0297335 0.013696863 0.223293936 0.35432382 3 75672391 75672584 194 + 0.000 0.304 12.541
ENSG00000242516 E005 0.6997360 0.017294482 0.437635341 0.57954608 3 75672585 75672683 99 + 0.000 0.224 12.112
ENSG00000242516 E006 0.7717566 0.020089554 1.000000000 1.00000000 3 75672684 75672694 11 + 0.211 0.224 0.109
ENSG00000242516 E007 1.2146470 0.011595096 0.715690983 0.81155397 3 75672695 75672707 13 + 0.211 0.304 0.698
ENSG00000242516 E008 3.5008447 0.005183580 0.205366160 0.33287989 3 75672708 75672769 62 + 0.352 0.607 1.283
ENSG00000242516 E009 3.7557011 0.004857210 0.170171087 0.28840681 3 75673194 75673238 45 + 0.352 0.625 1.362
ENSG00000242516 E010 3.6501701 0.005355252 0.465865573 0.60546928 3 75673847 75674006 160 + 0.459 0.607 0.698
ENSG00000242516 E011 2.6883944 0.006800480 0.006584415 0.02014596 3 75674413 75675763 1351 + 0.779 0.372 -1.886
ENSG00000242516 E012 6.3989805 0.003220097 0.824767110 0.88960683 3 75675764 75675880 117 + 0.731 0.784 0.213
ENSG00000242516 E013 1.0339894 0.015680340 0.030646778 0.07322596 3 75675968 75676128 161 + 0.544 0.178 -2.306
ENSG00000242516 E014 0.3289534 0.031898950 0.309415987   3 75676129 75676625 497 + 0.211 0.068 -1.886
ENSG00000242516 E015 15.5209365 0.002146932 0.802718594 0.87435751 3 75678833 75680092 1260 + 1.110 1.114 0.015
ENSG00000242516 E016 0.6244956 0.023660228 0.184391446 0.30674647 3 75686298 75687323 1026 + 0.352 0.126 -1.888
ENSG00000242516 E017 0.0000000       3 75740593 75742048 1456 +