ENSG00000241945

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000291576 ENSG00000241945 HEK293_OSMI2_2hA HEK293_TMG_2hB PWP2 protein_coding protein_coding 32.44402 45.47358 24.36329 1.825079 1.102003 -0.9000451 21.391973 34.249269 13.261091 0.1200049 0.2276503 -1.36820733 0.64208750 0.75546667 0.5469000 -0.20856667 0.001843702 0.001843702 FALSE TRUE
ENST00000456705 ENSG00000241945 HEK293_OSMI2_2hA HEK293_TMG_2hB PWP2 protein_coding protein_coding 32.44402 45.47358 24.36329 1.825079 1.102003 -0.9000451 8.662354 9.905139 9.114998 1.7739814 1.0895278 -0.11980882 0.27774583 0.21533333 0.3717333 0.15640000 0.036380780 0.001843702 FALSE TRUE
ENST00000476948 ENSG00000241945 HEK293_OSMI2_2hA HEK293_TMG_2hB PWP2 protein_coding retained_intron 32.44402 45.47358 24.36329 1.825079 1.102003 -0.9000451 1.544451 1.213599 1.165951 0.1944786 0.2678700 -0.05730224 0.05057917 0.02693333 0.0478000 0.02086667 0.307886087 0.001843702 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000241945 E001 83.6692622 0.0071198655 0.076470931 0.153852241 21 44107373 44107398 26 + 1.943 1.839 -0.347
ENSG00000241945 E002 114.3180344 0.0038325484 0.007620671 0.022826226 21 44107399 44107434 36 + 2.088 1.967 -0.405
ENSG00000241945 E003 128.1334269 0.0038334256 0.010237540 0.029349464 21 44108984 44109096 113 + 2.132 2.019 -0.376
ENSG00000241945 E004 75.3371296 0.0022912473 0.040701505 0.092328020 21 44113753 44113847 95 + 1.896 1.793 -0.347
ENSG00000241945 E005 21.6547499 0.0010974912 0.535449754 0.667271952 21 44114179 44114278 100 + 1.341 1.285 -0.193
ENSG00000241945 E006 0.0000000       21 44114576 44114624 49 +      
ENSG00000241945 E007 4.4899993 0.0035936404 0.253552971 0.390083236 21 44114625 44114768 144 + 0.811 0.644 -0.686
ENSG00000241945 E008 1.5748361 0.0276066730 0.525586933 0.658929704 21 44115264 44115399 136 + 0.476 0.356 -0.647
ENSG00000241945 E009 22.5303600 0.0008970363 0.142267573 0.251126624 21 44115691 44115920 230 + 1.229 1.344 0.402
ENSG00000241945 E010 87.6558088 0.0029719332 0.222673613 0.353578242 21 44117820 44117963 144 + 1.852 1.906 0.182
ENSG00000241945 E011 90.4914787 0.0051842623 0.432795776 0.575252779 21 44118763 44118833 71 + 1.879 1.916 0.125
ENSG00000241945 E012 1.9219759 0.0088119784 0.010587347 0.030179674 21 44119159 44119386 228 + 0.698 0.267 -2.227
ENSG00000241945 E013 44.1629635 0.0092618697 0.980287751 0.991683524 21 44119387 44119523 137 + 1.600 1.600 0.000
ENSG00000241945 E014 20.0225298 0.0010649787 0.001109857 0.004336132 21 44120348 44120496 149 + 1.020 1.322 1.081
ENSG00000241945 E015 46.1029392 0.0010535140 0.067079235 0.138504865 21 44120631 44120778 148 + 1.542 1.645 0.350
ENSG00000241945 E016 124.3949152 0.0009371471 0.038884426 0.088967848 21 44120952 44121102 151 + 1.987 2.057 0.234
ENSG00000241945 E017 0.3289534 0.0285276494 0.543070329   21 44121103 44122176 1074 + 0.175 0.084 -1.227
ENSG00000241945 E018 100.4378425 0.0003399473 0.435661499 0.577861232 21 44122177 44122357 181 + 1.930 1.954 0.080
ENSG00000241945 E019 120.7064689 0.0004015259 0.232900294 0.365868370 21 44124580 44124727 148 + 2.003 2.038 0.120
ENSG00000241945 E020 0.7500885 0.1340266356 0.038482043 0.088250767 21 44124728 44126010 1283 + 0.477 0.083 -3.242
ENSG00000241945 E021 93.3597820 0.0003643651 0.870133526 0.920464722 21 44126011 44126119 109 + 1.928 1.915 -0.042
ENSG00000241945 E022 29.0102825 0.0007690975 0.134794138 0.240806687 21 44126900 44126965 66 + 1.341 1.444 0.358
ENSG00000241945 E023 0.4470576 0.0228609284 0.198481380 0.324304094 21 44126966 44127574 609 + 0.300 0.084 -2.229
ENSG00000241945 E024 0.4470576 0.0228609284 0.198481380 0.324304094 21 44127575 44127693 119 + 0.300 0.084 -2.229
ENSG00000241945 E025 0.2955422 0.0287710995 0.541420990   21 44127694 44127798 105 + 0.175 0.084 -1.230
ENSG00000241945 E026 0.1472490 0.0425031301 0.211340701   21 44127799 44127931 133 + 0.175 0.000 -10.581
ENSG00000241945 E027 15.9531350 0.0213469591 0.457115328 0.597476839 21 44127932 44128150 219 + 1.113 1.195 0.295
ENSG00000241945 E028 1.9415663 0.0877882886 0.850435806 0.907211141 21 44128247 44128397 151 + 0.397 0.435 0.204
ENSG00000241945 E029 1.1675324 0.1784250435 0.981825364 0.992657642 21 44128552 44128626 75 + 0.300 0.314 0.094
ENSG00000241945 E030 0.4772466 0.0220308151 0.906361565 0.944490781 21 44128627 44128651 25 + 0.175 0.154 -0.229
ENSG00000241945 E031 39.4111156 0.0258338692 0.019286054 0.049957409 21 44130597 44131181 585 + 1.370 1.601 0.795