ENSG00000241860

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000466557 ENSG00000241860 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.55279 1.404675 1.920964 0.172971 0.1457381 0.4488503 0.06845763 0.17213364 0.03463501 0.172133643 0.03463501 -2.0287499 0.03139583 0.1072000 0.01950000 -0.08770000 0.928611280 0.000849212 TRUE FALSE
ENST00000484859 ENSG00000241860 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.55279 1.404675 1.920964 0.172971 0.1457381 0.4488503 1.05439696 0.50658149 0.92102802 0.063857758 0.08224641 0.8498286 0.42548750 0.3604000 0.48620000 0.12580000 0.456132452 0.000849212 TRUE FALSE
ENST00000491962 ENSG00000241860 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.55279 1.404675 1.920964 0.172971 0.1457381 0.4488503 0.90108323 0.11483747 0.72241430 0.114837466 0.21263597 2.5526090 0.26522500 0.0742000 0.36646667 0.29226667 0.139139748 0.000849212   FALSE
ENST00000655252 ENSG00000241860 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.55279 1.404675 1.920964 0.172971 0.1457381 0.4488503 0.32678675 0.53083862 0.09221800 0.041218289 0.04759145 -2.4035489 0.17957917 0.3973667 0.05046667 -0.34690000 0.000849212 0.000849212   FALSE
ENST00000662089 ENSG00000241860 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.55279 1.404675 1.920964 0.172971 0.1457381 0.4488503 0.19775514 0.08028376 0.13924748 0.008036672 0.03549423 0.7251682 0.09460000 0.0608000 0.07096667 0.01016667 0.879815747 0.000849212   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000241860 E001 0.0000000       1 141474 142807 1334 -      
ENSG00000241860 E002 1.7820001 0.010124503 0.78564244 0.86265776 1 142808 143011 204 - 0.403 0.489 0.446
ENSG00000241860 E003 2.0786882 0.008435545 0.77378702 0.85406806 1 146386 146509 124 - 0.482 0.489 0.031
ENSG00000241860 E004 0.0000000       1 146510 146641 132 -      
ENSG00000241860 E005 1.2618922 0.012705491 0.28509244 0.42539879 1 146642 149707 3066 - 0.403 0.263 -0.875
ENSG00000241860 E006 0.2966881 0.038406329 0.32575173   1 155767 155831 65 - 0.179 0.000 -12.270
ENSG00000241860 E007 0.1451727 0.707154837 0.69971663   1 164263 164791 529 - 0.098 0.000 -11.264
ENSG00000241860 E008 0.0000000       1 165491 165883 393 -      
ENSG00000241860 E009 0.0000000       1 165884 165888 5 -      
ENSG00000241860 E010 0.5117019 0.024105655 0.04435117 0.09902529 1 165889 165942 54 - 0.000 0.352 13.998
ENSG00000241860 E011 0.0000000       1 167129 167958 830 -      
ENSG00000241860 E012 0.3299976 0.032047978 0.12718935   1 167959 168099 141 - 0.000 0.263 13.412
ENSG00000241860 E013 0.3634088 0.052060113 0.13513459   1 168100 168165 66 - 0.000 0.263 13.416
ENSG00000241860 E014 0.1817044 0.048765362 0.35640153   1 168610 168767 158 - 0.000 0.151 12.415
ENSG00000241860 E015 0.1482932 0.185025601 0.37166012   1 169049 169264 216 - 0.000 0.150 12.399
ENSG00000241860 E016 0.1472490 0.364830384 0.68269116   1 172557 172688 132 - 0.098 0.000 -11.269
ENSG00000241860 E017 0.7533107 0.020045028 0.03993255 0.09091031 1 173753 173862 110 - 0.357 0.000 -13.592