ENSG00000240356

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000391616 ENSG00000240356 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_processed_pseudogene processed_transcript 16.51337 18.41691 17.9182 2.559409 0.6368037 -0.03958338 4.749395 4.8872870 5.410976 0.93221469 0.9252347 0.1465698 0.28661250 0.26150000 0.29913333 0.037633333 7.791643e-01 7.823597e-07    
ENST00000416673 ENSG00000240356 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_processed_pseudogene processed_transcript 16.51337 18.41691 17.9182 2.559409 0.6368037 -0.03958338 1.380942 0.6530189 2.256849 0.03407033 0.1615214 1.7735662 0.08268750 0.03643333 0.12690000 0.090466667 7.823597e-07 7.823597e-07    
MSTRG.19098.3 ENSG00000240356 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_processed_pseudogene   16.51337 18.41691 17.9182 2.559409 0.6368037 -0.03958338 6.116431 6.6337858 4.797852 0.96823438 0.5304228 -0.4666132 0.37367083 0.36003333 0.26940000 -0.090633333 2.367400e-01 7.823597e-07    
MSTRG.19098.4 ENSG00000240356 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_processed_pseudogene   16.51337 18.41691 17.9182 2.559409 0.6368037 -0.03958338 1.219054 1.3693753 1.238007 0.44052935 0.1520015 -0.1443895 0.07461250 0.07100000 0.06876667 -0.002233333 9.763590e-01 7.823597e-07    
MSTRG.19098.6 ENSG00000240356 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_processed_pseudogene   16.51337 18.41691 17.9182 2.559409 0.6368037 -0.03958338 1.467296 2.0922745 2.301107 0.54481408 0.1982392 0.1366330 0.08699583 0.11436667 0.12953333 0.015166667 8.402577e-01 7.823597e-07    
MSTRG.19098.7 ENSG00000240356 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_processed_pseudogene   16.51337 18.41691 17.9182 2.559409 0.6368037 -0.03958338 1.525654 2.7811716 1.845617 0.06068948 0.3448958 -0.5889716 0.09165833 0.15666667 0.10216667 -0.054500000 2.757975e-01 7.823597e-07    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000240356 E001 17.050623 0.0012976574 3.991329e-19 2.304618e-17 2 113610502 113611683 1182 - 1.555 0.767 -2.846
ENSG00000240356 E002 2.622629 0.0064141382 9.922725e-01 9.992621e-01 2 113611684 113611778 95 - 0.556 0.552 -0.017
ENSG00000240356 E003 109.563976 0.0036847880 9.649686e-01 9.819331e-01 2 113611779 113612247 469 - 2.045 2.039 -0.018
ENSG00000240356 E004 3.865593 0.0605902325 3.544155e-01 4.987113e-01 2 113621767 113621773 7 - 0.765 0.591 -0.736
ENSG00000240356 E005 17.607020 0.0039994714 2.272199e-01 3.590830e-01 2 113621774 113621880 107 - 1.200 1.297 0.342
ENSG00000240356 E006 31.779777 0.0009775555 2.236496e-01 3.547608e-01 2 113621881 113622016 136 - 1.465 1.536 0.243
ENSG00000240356 E007 11.135598 0.0016948236 5.969439e-02 1.261003e-01 2 113622017 113622019 3 - 0.962 1.150 0.684
ENSG00000240356 E008 16.477995 0.0011238674 7.878325e-02 1.575624e-01 2 113622113 113622161 49 - 1.146 1.291 0.513
ENSG00000240356 E009 114.084990 0.0004003740 1.576803e-02 4.221126e-02 2 113625609 113625729 121 - 2.018 2.086 0.227
ENSG00000240356 E010 12.178325 0.0015263937 8.698135e-01 9.202727e-01 2 113626478 113626571 94 - 1.110 1.123 0.046
ENSG00000240356 E011 14.784786 0.0036964817 2.399590e-01 3.740938e-01 2 113626830 113626880 51 - 1.257 1.150 -0.380
ENSG00000240356 E012 43.255797 0.0005276597 7.338502e-02 1.489343e-01 2 113626881 113627037 157 - 1.589 1.679 0.305
ENSG00000240356 E013 39.185264 0.0006476116 6.892208e-03 2.094394e-02 2 113627038 113627158 121 - 1.682 1.536 -0.498