ENSG00000238058

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000423793 ENSG00000238058 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 4.748789 6.415672 3.850048 1.252132 0.3584055 -0.7352287 0.3446371 0.8428081 0.2141998 0.2004941 0.2141998 -1.9274363 0.06478333 0.1362000 0.04953333 -0.08666667 0.251571776 0.009650852   FALSE
ENST00000651515 ENSG00000238058 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 4.748789 6.415672 3.850048 1.252132 0.3584055 -0.7352287 1.0928425 0.7562997 1.4622084 0.1811712 0.3646554 0.9420012 0.24868750 0.1154333 0.38260000 0.26716667 0.009650852 0.009650852   FALSE
MSTRG.33611.2 ENSG00000238058 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   4.748789 6.415672 3.850048 1.252132 0.3584055 -0.7352287 1.4610510 2.3306015 0.9242750 0.3632517 0.2145733 -1.3249601 0.29077500 0.3708667 0.25163333 -0.11923333 0.486871071 0.009650852   FALSE
MSTRG.33611.4 ENSG00000238058 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   4.748789 6.415672 3.850048 1.252132 0.3584055 -0.7352287 0.8733989 1.1752827 0.4807127 0.5824848 0.2853038 -1.2722806 0.17773333 0.1602667 0.11330000 -0.04696667 0.789272219 0.009650852   FALSE
MSTRG.33611.6 ENSG00000238058 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   4.748789 6.415672 3.850048 1.252132 0.3584055 -0.7352287 0.4521589 0.6193766 0.4207354 0.3966930 0.2330981 -0.5471219 0.09961667 0.1337667 0.11420000 -0.01956667 0.995846957 0.009650852   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000238058 E001 2.496130 0.0069315571 7.607704e-02 1.532323e-01 9 135907812 135907875 64 + 0.275 0.589 1.707
ENSG00000238058 E002 11.559570 0.1286002374 9.219763e-01 9.547701e-01 9 135907915 135908017 103 + 1.029 1.075 0.168
ENSG00000238058 E003 21.946349 0.0163465147 2.192082e-01 3.494181e-01 9 135908018 135908186 169 + 1.239 1.354 0.404
ENSG00000238058 E004 9.193792 0.0058915910 3.812520e-01 5.255535e-01 9 135908307 135908334 28 + 1.030 0.928 -0.379
ENSG00000238058 E005 8.086753 0.0600952116 4.112949e-01 5.548848e-01 9 135908335 135908335 1 + 0.993 0.872 -0.456
ENSG00000238058 E006 11.929239 0.0022546798 5.355112e-01 6.673208e-01 9 135908336 135908393 58 + 1.111 1.045 -0.240
ENSG00000238058 E007 11.017884 0.0016679636 9.775524e-01 9.900372e-01 9 135908394 135908428 35 + 1.047 1.045 -0.010
ENSG00000238058 E008 9.752983 0.0018555157 2.637221e-01 4.016283e-01 9 135908429 135908460 32 + 0.906 1.026 0.444
ENSG00000238058 E009 8.283582 0.0021766461 9.850593e-01 9.946834e-01 9 135908461 135908463 3 + 0.930 0.927 -0.011
ENSG00000238058 E010 8.394299 0.0021477674 6.369851e-01 7.509282e-01 9 135908464 135908482 19 + 0.972 0.914 -0.219
ENSG00000238058 E011 6.150759 0.0027357040 9.436026e-01 9.686252e-01 9 135908483 135908485 3 + 0.829 0.814 -0.055
ENSG00000238058 E012 6.675049 0.0059926754 4.426162e-01 5.842064e-01 9 135908486 135908499 14 + 0.930 0.829 -0.384
ENSG00000238058 E013 8.719771 0.0204644481 4.630032e-02 1.025764e-01 9 135908500 135908651 152 + 1.096 0.849 -0.920
ENSG00000238058 E014 32.736220 0.0007943601 2.626540e-01 4.004395e-01 9 135908652 135908788 137 + 1.446 1.508 0.213
ENSG00000238058 E015 20.207258 0.0036808956 5.257272e-04 2.255687e-03 9 135909379 135909486 108 + 1.064 1.364 1.061
ENSG00000238058 E016 1.510192 0.0247281623 1.288643e-01 2.325730e-01 9 135910461 135910516 56 + 0.562 0.291 -1.470
ENSG00000238058 E017 14.687670 0.0015167634 2.887191e-02 6.974430e-02 9 135913404 135913731 328 + 1.012 1.214 0.729
ENSG00000238058 E018 10.130812 0.0431736468 1.302121e-01 2.344583e-01 9 135915528 135915786 259 + 0.856 1.072 0.806
ENSG00000238058 E019 10.753483 0.0016499983 3.692163e-16 1.476296e-14 9 135915787 135916146 360 + 1.418 0.589 -3.127