ENSG00000237978

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000421498 ENSG00000237978 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.500576 3.158933 1.921555 0.3401048 0.2859334 -0.7142339 0.5895283 0.58353028 0.5726322 0.16353335 0.15647957 -0.02673625 0.24191250 0.18886667 0.2961667 0.1073000 0.49674794 0.01538373   FALSE
ENST00000432385 ENSG00000237978 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.500576 3.158933 1.921555 0.3401048 0.2859334 -0.7142339 0.1426332 0.15458945 0.2330078 0.08196543 0.15775253 0.56213055 0.05589583 0.04476667 0.1189667 0.0742000 0.83952119 0.01538373   FALSE
ENST00000668466 ENSG00000237978 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.500576 3.158933 1.921555 0.3401048 0.2859334 -0.7142339 0.1317352 0.09175133 0.1224984 0.02811668 0.03942878 0.38092681 0.06137917 0.03100000 0.0600000 0.0290000 0.38383303 0.01538373   FALSE
MSTRG.24096.7 ENSG00000237978 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   2.500576 3.158933 1.921555 0.3401048 0.2859334 -0.7142339 1.2801645 2.24858987 0.8852869 0.34366738 0.16022739 -1.33500037 0.50781250 0.70833333 0.4553000 -0.2530333 0.01538373 0.01538373   FALSE
MSTRG.24096.8 ENSG00000237978 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   2.500576 3.158933 1.921555 0.3401048 0.2859334 -0.7142339 0.2288536 0.00000000 0.0000000 0.00000000 0.00000000 0.00000000 0.07765833 0.00000000 0.0000000 0.0000000   0.01538373   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000237978 E001 0.1451727 0.049296876 0.235677572   3 178526505 178526625 121 - 0.173 0.000 -11.763
ENSG00000237978 E002 0.0000000       3 178535714 178535899 186 -      
ENSG00000237978 E003 0.0000000       3 178537261 178537396 136 -      
ENSG00000237978 E004 0.0000000       3 178729193 178729283 91 -      
ENSG00000237978 E005 0.2966881 0.029349653 0.065903901   3 178729284 178729392 109 - 0.296 0.000 -14.643
ENSG00000237978 E006 0.4439371 0.022205357 0.018114271 0.047375535 3 178746939 178747111 173 - 0.392 0.000 -15.082
ENSG00000237978 E007 0.1482932 0.042322414 1.000000000   3 178748289 178748403 115 - 0.000 0.085 10.813
ENSG00000237978 E008 0.7384472 0.092631177 0.215330125 0.344811771 3 178748404 178748485 82 - 0.392 0.155 -1.770
ENSG00000237978 E009 2.7864761 0.271612592 0.653954302 0.764279338 3 178748988 178749041 54 - 0.595 0.511 -0.388
ENSG00000237978 E010 3.5259528 0.074376946 0.821584219 0.887473775 3 178749042 178749045 4 - 0.594 0.611 0.073
ENSG00000237978 E011 6.5674529 0.003220097 0.274889332 0.414117717 3 178749046 178749109 64 - 0.945 0.793 -0.586
ENSG00000237978 E012 10.6605411 0.001956482 0.904659323 0.943298061 3 178749110 178749236 127 - 1.051 1.014 -0.137
ENSG00000237978 E013 0.4783925 0.022171192 0.225644371 0.357159023 3 178757080 178757133 54 - 0.296 0.085 -2.170
ENSG00000237978 E014 0.4783925 0.022171192 0.225644371 0.357159023 3 178757134 178757136 3 - 0.296 0.085 -2.170
ENSG00000237978 E015 1.7390239 0.008916296 0.355348763 0.499701285 3 178801793 178801934 142 - 0.537 0.362 -0.909
ENSG00000237978 E016 0.1515154 0.044741062 0.236027284   3 178801935 178801936 2 - 0.173 0.000 -13.824
ENSG00000237978 E017 2.9558636 0.006908924 0.061057456 0.128414045 3 178841545 178841616 72 - 0.770 0.470 -1.325
ENSG00000237978 E018 0.0000000       3 178846413 178846477 65 -      
ENSG00000237978 E019 15.5448603 0.002146932 0.002245927 0.007986113 3 178859489 178859623 135 - 0.991 1.231 0.867
ENSG00000237978 E020 9.1883765 0.002404637 0.070297196 0.143850285 3 178860294 178860453 160 - 0.836 1.014 0.669
ENSG00000237978 E021 0.1482932 0.042322414 1.000000000   3 178909599 178909706 108 - 0.000 0.085 10.813
ENSG00000237978 E022 0.0000000       3 178921688 178921910 223 -      
ENSG00000237978 E023 0.3686942 0.032558665 0.591530203 0.714286039 3 178934721 178937352 2632 - 0.173 0.085 -1.167