ENSG00000237943

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000414894 ENSG00000237943 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKCQ-AS1 lncRNA lncRNA 6.731269 7.183433 5.806421 0.3422961 0.7736515 -0.3065488 0.05166006 0.0000000 0.4132805 0.00000000 0.4132805 5.4035422 0.00702500 0.00000000 0.05620000 0.05620000 0.7783569 7.245297e-05   FALSE
ENST00000445427 ENSG00000237943 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKCQ-AS1 lncRNA lncRNA 6.731269 7.183433 5.806421 0.3422961 0.7736515 -0.3065488 1.13756579 0.7757929 1.1593953 0.77579292 0.5806733 0.5735416 0.17921250 0.10226667 0.23033333 0.12806667 0.5421117 7.245297e-05 TRUE FALSE
ENST00000449648 ENSG00000237943 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKCQ-AS1 lncRNA lncRNA 6.731269 7.183433 5.806421 0.3422961 0.7736515 -0.3065488 0.54924373 1.0742253 0.3688782 0.04408977 0.2013268 -1.5168585 0.08099583 0.14963333 0.05886667 -0.09076667 0.3938093 7.245297e-05   FALSE
ENST00000455810 ENSG00000237943 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKCQ-AS1 lncRNA lncRNA 6.731269 7.183433 5.806421 0.3422961 0.7736515 -0.3065488 3.15129221 3.3389122 1.8859338 0.28782489 0.2789873 -0.8207840 0.46616250 0.46390000 0.32386667 -0.14003333 0.0213256 7.245297e-05   FALSE
ENST00000663449 ENSG00000237943 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKCQ-AS1 lncRNA lncRNA 6.731269 7.183433 5.806421 0.3422961 0.7736515 -0.3065488 0.51574347 1.3515454 0.5014127 0.67726025 0.5014127 -1.4126852 0.07039167 0.19500000 0.06820000 -0.12680000 0.5569548 7.245297e-05   FALSE
MSTRG.3504.2 ENSG00000237943 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKCQ-AS1 lncRNA   6.731269 7.183433 5.806421 0.3422961 0.7736515 -0.3065488 0.21040505 0.2154097 0.4369433 0.11433146 0.2311801 0.9875422 0.03518750 0.03123333 0.08680000 0.05556667 0.8430110 7.245297e-05 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000237943 E001 1.9626472 0.0076632132 1.381846e-01 2.455622e-01 10 6580419 6580424 6 + 0.604 0.348 -1.300
ENSG00000237943 E002 9.1747200 0.0278182938 4.330319e-02 9.711691e-02 10 6580425 6580499 75 + 1.145 0.880 -0.976
ENSG00000237943 E003 9.2006426 0.0195479294 6.040616e-02 1.273057e-01 10 6580500 6580505 6 + 1.131 0.894 -0.871
ENSG00000237943 E004 16.4311194 0.0011558478 2.643214e-01 4.022800e-01 10 6580506 6580555 50 + 1.282 1.176 -0.374
ENSG00000237943 E005 14.2762590 0.0026449348 4.415371e-01 5.831762e-01 10 6580556 6580561 6 + 1.207 1.123 -0.299
ENSG00000237943 E006 89.4063740 0.0004125868 4.199153e-01 5.631739e-01 10 6580562 6580927 366 + 1.960 1.918 -0.140
ENSG00000237943 E007 3.0550148 0.0061531814 6.336310e-03 1.949801e-02 10 6581669 6582137 469 + 0.820 0.393 -1.929
ENSG00000237943 E008 15.3084052 0.0073063858 1.183853e-01 2.176203e-01 10 6582138 6582201 64 + 1.291 1.137 -0.547
ENSG00000237943 E009 0.7394793 0.0157742589 5.130450e-02 1.114760e-01 10 6583622 6583622 1 + 0.436 0.095 -2.816
ENSG00000237943 E010 1.8905393 0.0081879516 3.588050e-01 5.031867e-01 10 6583623 6583675 53 + 0.555 0.393 -0.817
ENSG00000237943 E011 85.1583641 0.0004251528 5.539944e-02 1.186750e-01 10 6583676 6583804 129 + 1.869 1.930 0.205
ENSG00000237943 E012 35.0528251 0.0005927814 5.392256e-02 1.161258e-01 10 6583805 6583810 6 + 1.457 1.563 0.365
ENSG00000237943 E013 42.0763053 0.0005398227 6.081416e-02 1.280075e-01 10 6583811 6583830 20 + 1.545 1.638 0.316
ENSG00000237943 E014 53.3405354 0.0005175422 1.021649e-02 2.929888e-02 10 6583831 6583860 30 + 1.628 1.744 0.394
ENSG00000237943 E015 64.3927610 0.0011337018 1.138074e-02 3.207448e-02 10 6583861 6583914 54 + 1.715 1.821 0.356
ENSG00000237943 E016 36.6177062 0.0006577517 7.437467e-02 1.505377e-01 10 6583915 6583918 4 + 1.482 1.577 0.326
ENSG00000237943 E017 47.5773327 0.0005104546 5.980717e-01 7.197398e-01 10 6583919 6584117 199 + 1.649 1.664 0.050
ENSG00000237943 E018 56.5942006 0.0005424519 8.706460e-03 2.555209e-02 10 6584118 6584195 78 + 1.649 1.765 0.391
ENSG00000237943 E019 49.5939737 0.0033714676 3.392369e-01 4.831482e-01 10 6584196 6585303 1108 + 1.719 1.652 -0.227
ENSG00000237943 E020 3.2944586 0.0047438183 2.965321e-04 1.365843e-03 10 6585558 6585712 155 + 0.898 0.348 -2.493
ENSG00000237943 E021 1.0267042 0.0127596600 4.108358e-04 1.815780e-03 10 6585798 6585846 49 + 0.604 0.000 -15.174
ENSG00000237943 E022 4.6813614 0.0035863741 1.131658e-03 4.410016e-03 10 6586224 6586762 539 + 0.984 0.538 -1.815
ENSG00000237943 E023 1.3660633 0.0110841543 6.407705e-01 7.539598e-01 10 6586763 6586880 118 + 0.436 0.347 -0.496
ENSG00000237943 E024 0.7696683 0.0152053478 3.017373e-01 4.435496e-01 10 6586881 6586920 40 + 0.361 0.173 -1.400
ENSG00000237943 E025 2.6000332 0.0076764097 1.479900e-05 9.458288e-05 10 6588266 6588396 131 + 0.874 0.173 -3.722
ENSG00000237943 E026 2.0755572 0.0070754724 1.216752e-05 7.925937e-05 10 6590950 6591134 185 + 0.820 0.095 -4.516
ENSG00000237943 E027 0.1472490 0.0426948282 2.944699e-01   10 6591135 6591179 45 + 0.156 0.000 -12.453
ENSG00000237943 E028 0.5891098 0.0182563866 9.739858e-03 2.812271e-02 10 6596846 6596894 49 + 0.436 0.000 -14.451
ENSG00000237943 E029 0.0000000       10 6607287 6607320 34 +      
ENSG00000237943 E030 0.2903454 0.2720322890 1.408048e-01   10 6607321 6607415 95 + 0.270 0.000 -12.755
ENSG00000237943 E031 1.3285892 0.0097630204 1.310244e-03 5.011404e-03 10 6608348 6608375 28 + 0.649 0.095 -3.815
ENSG00000237943 E032 1.3285892 0.0097630204 1.310244e-03 5.011404e-03 10 6608376 6608408 33 + 0.649 0.095 -3.815
ENSG00000237943 E033 0.5964967 0.0244135603 1.265158e-01 2.292996e-01 10 6613631 6613689 59 + 0.361 0.095 -2.402
ENSG00000237943 E034 0.1451727 0.0427252344 2.949747e-01   10 6613690 6613903 214 + 0.156 0.000 -12.452
ENSG00000237943 E035 0.2998086 0.0287332610 6.937549e-01   10 6613934 6613987 54 + 0.156 0.095 -0.817
ENSG00000237943 E036 1.0738451 0.0124392849 8.409197e-03 2.481112e-02 10 6615370 6615518 149 + 0.555 0.095 -3.400
ENSG00000237943 E037 0.5954526 0.0193874923 9.727479e-03 2.809193e-02 10 6615519 6615637 119 + 0.436 0.000 -14.444
ENSG00000237943 E038 1.1856066 0.0111265241 3.313806e-03 1.118837e-02 10 6615763 6615924 162 + 0.604 0.095 -3.623
ENSG00000237943 E039 0.3030308 0.4327801411 1.699869e-01   10 6615925 6615959 35 + 0.271 0.000 -12.581
ENSG00000237943 E040 0.0000000       10 6616006 6616921 916 +