ENSG00000237638

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000666526 ENSG00000237638 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC02245 lncRNA lncRNA 7.942914 14.94789 4.902537 0.2479083 0.2854373 -1.606366 2.2188087 4.1227904 0.3915719 0.30075085 0.26333604 -3.3633859 0.2611625 0.27530000 0.07443333 -0.20086667 0.18549376 0.01671784   FALSE
ENST00000685506 ENSG00000237638 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC02245 lncRNA lncRNA 7.942914 14.94789 4.902537 0.2479083 0.2854373 -1.606366 2.0729932 3.7876928 1.4137625 0.04737389 0.04106941 -1.4154147 0.2733208 0.25363333 0.29086667 0.03723333 0.65671205 0.01671784   FALSE
MSTRG.18531.4 ENSG00000237638 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC02245 lncRNA   7.942914 14.94789 4.902537 0.2479083 0.2854373 -1.606366 0.3691667 0.2780109 0.2104154 0.07281916 0.04774343 -0.3858985 0.0613000 0.01853333 0.04230000 0.02376667 0.14564336 0.01671784   FALSE
MSTRG.18531.8 ENSG00000237638 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC02245 lncRNA   7.942914 14.94789 4.902537 0.2479083 0.2854373 -1.606366 3.0330823 6.3673346 2.8289979 0.25736596 0.04284280 -1.1675718 0.3585667 0.42656667 0.57986667 0.15330000 0.01716044 0.01671784   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000237638 E001 0.0000000       2 64901840 64902304 465 -      
ENSG00000237638 E002 0.0000000       2 64902305 64903672 1368 -      
ENSG00000237638 E003 0.1472490 0.0442059052 0.137268426   2 64903673 64904113 441 - 0.203 0.000 -11.116
ENSG00000237638 E004 0.1482932 0.0415597149 1.000000000   2 64904114 64904620 507 - 0.000 0.071 9.439
ENSG00000237638 E005 0.0000000       2 64904991 64905135 145 -      
ENSG00000237638 E006 0.0000000       2 64905136 64905137 2 -      
ENSG00000237638 E007 0.0000000       2 64932345 64932449 105 -      
ENSG00000237638 E008 0.4439371 0.0217889440 0.006076781 0.01881282 2 64945590 64946928 1339 - 0.445 0.000 -14.466
ENSG00000237638 E009 0.0000000       2 64951955 64952048 94 -      
ENSG00000237638 E010 5.4594410 0.0032227416 0.156461383 0.27040394 2 64953253 64953736 484 - 0.877 0.676 -0.805
ENSG00000237638 E011 4.4440785 0.0616593295 0.016244598 0.04326515 2 64953737 64954044 308 - 0.940 0.526 -1.709
ENSG00000237638 E012 1.5489982 0.0116425536 0.444457375 0.58602423 2 64955893 64955984 92 - 0.203 0.352 1.073
ENSG00000237638 E013 0.3666179 0.0275349326 0.385231477 0.52942359 2 64970176 64970260 85 - 0.203 0.071 -1.735
ENSG00000237638 E014 1.5834430 0.0097115312 0.167535486 0.28498016 2 64970572 64970785 214 - 0.529 0.277 -1.414
ENSG00000237638 E015 0.8062992 0.0592800054 0.324739758 0.46815809 2 64991120 64991258 139 - 0.000 0.235 11.266
ENSG00000237638 E016 0.3289534 0.0288416554 0.383635674   2 65019142 65019187 46 - 0.203 0.071 -1.738
ENSG00000237638 E017 0.2214452 0.0381757748 1.000000000   2 65047854 65047889 36 - 0.000 0.071 9.455
ENSG00000237638 E018 13.4987663 0.0014444354 0.040628384 0.09218206 2 65047890 65047953 64 - 0.877 1.112 0.868
ENSG00000237638 E019 99.7853711 0.0005031072 0.078128449 0.15646420 2 65047954 65048212 259 - 1.859 1.917 0.194
ENSG00000237638 E020 15.9057394 0.0012502128 0.961837265 0.97992789 2 65051279 65051337 59 - 1.130 1.130 0.000
ENSG00000237638 E021 44.9012903 0.0005192465 0.196423875 0.32175461 2 65055530 65055620 91 - 1.623 1.547 -0.261
ENSG00000237638 E022 83.0976653 0.0004269890 0.928436791 0.95896522 2 65055915 65056226 312 - 1.826 1.825 -0.004