ENSG00000237550

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000418824 ENSG00000237550 HEK293_OSMI2_2hA HEK293_TMG_2hB transcribed_processed_pseudogene processed_transcript 54.00287 20.90446 173.7385 13.67226 32.98487 3.054428 11.79328 20.80688 6.984385 13.73359 0.4539535 -1.573485 0.7157125 0.9741667 0.04213333 -0.9320333 5.854009e-05 1.937828e-96 FALSE TRUE
ENST00000692949 ENSG00000237550 HEK293_OSMI2_2hA HEK293_TMG_2hB transcribed_processed_pseudogene processed_transcript 54.00287 20.90446 173.7385 13.67226 32.98487 3.054428 42.19739 0.00000 166.754131 0.00000 32.5315257 14.025521 0.2810583 0.0000000 0.95786667 0.9578667 1.937828e-96 1.937828e-96 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000237550 E001 57.52241 0.0006465472 3.838743e-07 3.472631e-06 15 82372196 82372222 27 - 1.457 1.715 0.879
ENSG00000237550 E002 57.52241 0.0006465472 3.838743e-07 3.472631e-06 15 82372223 82372223 1 - 1.457 1.715 0.879
ENSG00000237550 E003 57.52241 0.0006465472 3.838743e-07 3.472631e-06 15 82372224 82372224 1 - 1.457 1.715 0.879
ENSG00000237550 E004 58.85424 0.0005785478 2.263509e-05 1.385822e-04 15 82372225 82372309 85 - 1.525 1.718 0.657
ENSG00000237550 E005 58.63457 0.0005667172 7.797825e-01 8.584363e-01 15 82372310 82372416 107 - 1.745 1.676 -0.235
ENSG00000237550 E006 24.74604 0.0019169837 7.989426e-08 8.269534e-07 15 82372417 82372469 53 - 1.649 1.209 -1.519
ENSG00000237550 E007 26.78537 0.0126331529 3.536576e-08 3.924519e-07 15 82372470 82372497 28 - 1.746 1.181 -1.946
ENSG00000237550 E008 39.18060 0.0311253340 5.714003e-05 3.172721e-04 15 82372498 82372916 419 - 1.891 1.332 -1.909