ENSG00000237491

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000434264 ENSG00000237491 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01409 lncRNA lncRNA 2.939902 1.296476 3.027497 0.1208867 0.4528897 1.217202 0.09340725 0.00000000 0.20327268 0.00000000 0.13828298 4.4146272 0.03651250 0.00000000 0.08003333 0.08003333 4.786458e-01 8.256388e-07   FALSE
ENST00000457084 ENSG00000237491 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01409 lncRNA lncRNA 2.939902 1.296476 3.027497 0.1208867 0.4528897 1.217202 0.73298466 0.18679064 0.59473845 0.01965009 0.32136296 1.6196497 0.22663333 0.14933333 0.17293333 0.02360000 9.773394e-01 8.256388e-07   FALSE
ENST00000585768 ENSG00000237491 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01409 lncRNA lncRNA 2.939902 1.296476 3.027497 0.1208867 0.4528897 1.217202 0.29196949 0.15556145 0.12216499 0.09994026 0.12216499 -0.3250267 0.09516250 0.12786667 0.03166667 -0.09620000 5.410199e-01 8.256388e-07   FALSE
ENST00000585826 ENSG00000237491 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01409 lncRNA lncRNA 2.939902 1.296476 3.027497 0.1208867 0.4528897 1.217202 0.53852215 0.00000000 1.00907674 0.00000000 0.32412855 6.6711189 0.14626250 0.00000000 0.31570000 0.31570000 8.256388e-07 8.256388e-07   FALSE
ENST00000588951 ENSG00000237491 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01409 lncRNA lncRNA 2.939902 1.296476 3.027497 0.1208867 0.4528897 1.217202 0.07485581 0.09355158 0.00000000 0.09355158 0.00000000 -3.3722776 0.03083333 0.06153333 0.00000000 -0.06153333 5.999721e-01 8.256388e-07 FALSE FALSE
ENST00000589899 ENSG00000237491 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01409 lncRNA lncRNA 2.939902 1.296476 3.027497 0.1208867 0.4528897 1.217202 0.24484174 0.02919764 0.14189466 0.02919764 0.14189466 1.9542327 0.07581250 0.01920000 0.04850000 0.02930000 9.752967e-01 8.256388e-07 TRUE FALSE
ENST00000591702 ENSG00000237491 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01409 lncRNA lncRNA 2.939902 1.296476 3.027497 0.1208867 0.4528897 1.217202 0.35021991 0.19085146 0.22475698 0.02783369 0.02308524 0.2250391 0.12550000 0.14580000 0.07813333 -0.06766667 2.527138e-01 8.256388e-07 FALSE TRUE
ENST00000644482 ENSG00000237491 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01409 lncRNA transcribed_processed_pseudogene 2.939902 1.296476 3.027497 0.1208867 0.4528897 1.217202 0.07879945 0.17484125 0.00000000 0.17484125 0.00000000 -4.2082148 0.03885833 0.11496667 0.00000000 -0.11496667 6.480204e-01 8.256388e-07   FALSE
ENST00000657896 ENSG00000237491 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01409 lncRNA lncRNA 2.939902 1.296476 3.027497 0.1208867 0.4528897 1.217202 0.04501562 0.06080626 0.00000000 0.06080626 0.00000000 -2.8238769 0.02316667 0.05496667 0.00000000 -0.05496667 5.776511e-01 8.256388e-07 FALSE FALSE
ENST00000665719 ENSG00000237491 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01409 lncRNA lncRNA 2.939902 1.296476 3.027497 0.1208867 0.4528897 1.217202 0.02042158 0.11625575 0.04711685 0.11625575 0.04711685 -1.1443609 0.01570000 0.10510000 0.02050000 -0.08460000 8.648820e-01 8.256388e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000237491 E001 0.0000000       1 778747 778757 11 +      
ENSG00000237491 E002 0.0000000       1 778758 778759 2 +      
ENSG00000237491 E003 0.0000000       1 778760 778769 10 +      
ENSG00000237491 E004 0.0000000       1 778770 778781 12 +      
ENSG00000237491 E005 0.0000000       1 778782 778795 14 +      
ENSG00000237491 E006 0.0000000       1 778796 778801 6 +      
ENSG00000237491 E007 0.2987644 0.031073586 0.389592782   1 778802 778808 7 + 0.179 0.000 -10.747
ENSG00000237491 E008 0.2987644 0.031073586 0.389592782   1 778809 778811 3 + 0.179 0.000 -12.405
ENSG00000237491 E009 0.5922303 0.018483196 0.610696648 0.729989008 1 778812 778848 37 + 0.247 0.151 -0.882
ENSG00000237491 E010 2.4637546 0.007243862 0.597181461 0.718983663 1 778849 778929 81 + 0.518 0.591 0.340
ENSG00000237491 E011 2.4637546 0.007243862 0.597181461 0.718983663 1 778930 778936 7 + 0.518 0.591 0.340
ENSG00000237491 E012 2.6485794 0.006571990 0.187943856 0.311129945 1 778937 778971 35 + 0.483 0.675 0.872
ENSG00000237491 E013 3.0904402 0.005746056 0.476631715 0.615239787 1 778972 779092 121 + 0.580 0.675 0.413
ENSG00000237491 E014 2.0713013 0.007647857 0.621711854 0.738654695 1 781937 782043 107 + 0.518 0.425 -0.466
ENSG00000237491 E015 1.8069791 0.008625161 0.573614031 0.699553352 1 782044 782136 93 + 0.403 0.488 0.442
ENSG00000237491 E016 1.2909221 0.010871264 0.465612988 0.605278034 1 782137 782191 55 + 0.305 0.425 0.704
ENSG00000237491 E017 1.8928311 0.011237331 0.780993131 0.859279770 1 783111 783363 253 + 0.483 0.425 -0.297
ENSG00000237491 E018 1.6984293 0.008559914 0.032131193 0.076113261 1 784370 784395 26 + 0.550 0.151 -2.617
ENSG00000237491 E019 2.7378190 0.005807420 0.001340911 0.005112928 1 784396 784493 98 + 0.727 0.151 -3.383
ENSG00000237491 E020 4.8811264 0.005618101 0.026712662 0.065393849 1 784494 784977 484 + 0.868 0.543 -1.353
ENSG00000237491 E021 3.7007261 0.039097297 0.248704185 0.384393477 1 785800 786392 593 + 0.581 0.748 0.711
ENSG00000237491 E022 4.6522151 0.003752759 0.936701554 0.964189927 1 786393 787672 1280 + 0.747 0.746 -0.006
ENSG00000237491 E023 0.9974562 0.014771316 0.528435778 0.661358998 1 792882 793041 160 + 0.247 0.352 0.705
ENSG00000237491 E024 0.1817044 0.041168396 0.290427116   1 795470 795582 113 + 0.000 0.151 12.257
ENSG00000237491 E025 0.4439371 0.022240915 0.201809258 0.328446504 1 801607 801876 270 + 0.247 0.000 -12.933
ENSG00000237491 E026 0.2214452 0.051951109 0.289274175   1 803567 803667 101 + 0.000 0.151 12.259
ENSG00000237491 E027 0.0000000       1 803836 803918 83 +      
ENSG00000237491 E028 0.2934659 0.029166033 0.701284919   1 803919 803921 3 + 0.099 0.151 0.702
ENSG00000237491 E029 0.4386386 0.075163221 0.938045028 0.965062494 1 803922 803933 12 + 0.179 0.150 -0.301
ENSG00000237491 E030 0.4417591 0.037112221 0.314144863 0.456828593 1 803934 803950 17 + 0.099 0.262 1.698
ENSG00000237491 E031 1.5070833 0.014665453 0.419073536 0.562327614 1 803951 804222 272 + 0.357 0.487 0.700
ENSG00000237491 E032 1.0685465 0.013629602 0.631149803 0.746236265 1 804776 804840 65 + 0.357 0.263 -0.619
ENSG00000237491 E033 0.8825757 0.014801059 0.272326962 0.411190769 1 804841 804966 126 + 0.357 0.151 -1.619
ENSG00000237491 E034 1.6973070 0.022622752 0.418656796 0.561891793 1 804967 806385 1419 + 0.357 0.489 0.707
ENSG00000237491 E035 0.6653823 0.018045663 0.614936120 0.733334425 1 806386 807216 831 + 0.247 0.151 -0.879
ENSG00000237491 E036 1.3953218 0.011865540 0.268165822 0.406598081 1 807217 807323 107 + 0.305 0.488 1.024
ENSG00000237491 E037 1.4319422 0.012406958 0.654973347 0.764998305 1 807324 808378 1055 + 0.357 0.425 0.382
ENSG00000237491 E038 0.5149111 0.021282387 0.304443050 0.446452009 1 809622 809657 36 + 0.099 0.263 1.705
ENSG00000237491 E039 0.8417882 0.016476754 0.302998454 0.444925399 1 809658 810065 408 + 0.179 0.352 1.290