ENSG00000237489

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000637128 ENSG00000237489 HEK293_OSMI2_2hA HEK293_TMG_2hB C10orf143 protein_coding protein_coding 5.665938 7.319364 6.610107 0.1481539 0.5761791 -0.1468335 2.8933075 4.3228460 3.3254317 0.32882486 0.23132387 -0.3774415 0.49289167 0.59230000 0.50496667 -0.087333333 4.889431e-01 6.93838e-17 FALSE FALSE
ENST00000647406 ENSG00000237489 HEK293_OSMI2_2hA HEK293_TMG_2hB C10orf143 protein_coding nonsense_mediated_decay 5.665938 7.319364 6.610107 0.1481539 0.5761791 -0.1468335 0.5731680 0.6641878 0.5653083 0.02997143 0.04268507 -0.2288153 0.10540000 0.09083333 0.08586667 -0.004966667 9.409647e-01 6.93838e-17 TRUE FALSE
MSTRG.4817.2 ENSG00000237489 HEK293_OSMI2_2hA HEK293_TMG_2hB C10orf143 protein_coding   5.665938 7.319364 6.610107 0.1481539 0.5761791 -0.1468335 0.8257378 1.5023132 0.6885844 0.32657102 0.17118742 -1.1142506 0.14965417 0.20390000 0.10123333 -0.102666667 1.948758e-01 6.93838e-17 TRUE FALSE
MSTRG.4817.4 ENSG00000237489 HEK293_OSMI2_2hA HEK293_TMG_2hB C10orf143 protein_coding   5.665938 7.319364 6.610107 0.1481539 0.5761791 -0.1468335 0.6195875 0.4565356 0.5240436 0.07466281 0.28368795 0.1949702 0.11868750 0.06243333 0.07306667 0.010633333 9.480108e-01 6.93838e-17   FALSE
MSTRG.4817.5 ENSG00000237489 HEK293_OSMI2_2hA HEK293_TMG_2hB C10orf143 protein_coding   5.665938 7.319364 6.610107 0.1481539 0.5761791 -0.1468335 0.4039569 0.0000000 1.1355283 0.00000000 0.05207864 6.8398693 0.06947083 0.00000000 0.17476667 0.174766667 6.938380e-17 6.93838e-17 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000237489 E001 0.2214452 0.0390181290 0.669882825   10 130020025 130021978 1954 - 0.000 0.104 8.019
ENSG00000237489 E002 0.3332198 0.0294135291 0.793588866   10 130023734 130023889 156 - 0.143 0.104 -0.529
ENSG00000237489 E003 0.4720498 0.2829827184 0.455262960 0.59579311 10 130035858 130035970 113 - 0.250 0.104 -1.520
ENSG00000237489 E004 1.3609682 0.0224503803 0.028801278 0.06960474 10 130063604 130063670 67 - 0.572 0.188 -2.338
ENSG00000237489 E005 23.6002633 0.0008364986 0.688415906 0.79055994 10 130063896 130064077 182 - 1.360 1.386 0.090
ENSG00000237489 E006 22.9287683 0.0009231837 0.992090472 0.99914711 10 130064078 130064110 33 - 1.367 1.366 -0.005
ENSG00000237489 E007 34.7209407 0.0020499443 0.881569800 0.92811287 10 130064111 130064213 103 - 1.534 1.542 0.026
ENSG00000237489 E008 32.2293246 0.0007399656 0.758385354 0.84301281 10 130064214 130064289 76 - 1.498 1.514 0.055
ENSG00000237489 E009 27.5095693 0.0007599797 0.173723026 0.29302681 10 130064290 130064339 50 - 1.381 1.469 0.302
ENSG00000237489 E010 29.6666808 0.0007726310 0.295742802 0.43689293 10 130064340 130064383 44 - 1.428 1.492 0.221
ENSG00000237489 E011 28.6334648 0.0007056617 0.709965304 0.80720658 10 130064862 130066105 1244 - 1.470 1.444 -0.089
ENSG00000237489 E012 15.8409315 0.0525670381 0.512075828 0.64700464 10 130066374 130068275 1902 - 1.268 1.173 -0.337
ENSG00000237489 E013 8.5293404 0.0087793580 0.544215050 0.67471554 10 130068276 130068485 210 - 0.905 0.975 0.261
ENSG00000237489 E014 15.4359731 0.0056584212 0.111915218 0.20837763 10 130068486 130068608 123 - 1.091 1.238 0.525
ENSG00000237489 E015 33.4455023 0.0006535822 0.275264181 0.41454397 10 130079566 130079628 63 - 1.476 1.539 0.216
ENSG00000237489 E016 50.3072211 0.0004818655 0.690365837 0.79207689 10 130079737 130079901 165 - 1.680 1.697 0.056
ENSG00000237489 E017 4.4295328 0.0036543942 0.972636987 0.98692167 10 130101094 130101211 118 - 0.724 0.727 0.011
ENSG00000237489 E018 13.6115461 0.0089770429 0.541263411 0.67226598 10 130104083 130104230 148 - 1.178 1.114 -0.232
ENSG00000237489 E019 3.1196722 0.0322074569 0.180479572 0.30178458 10 130104378 130104464 87 - 0.724 0.502 -0.981
ENSG00000237489 E020 2.3280451 0.0183153525 0.666131513 0.77364289 10 130110121 130110180 60 - 0.573 0.499 -0.343
ENSG00000237489 E021 24.3831044 0.0011997986 0.007113056 0.02151840 10 130110181 130110486 306 - 1.493 1.306 -0.645
ENSG00000237489 E022 15.7282772 0.0012339769 0.215154778 0.34461546 10 130110704 130110830 127 - 1.269 1.163 -0.377