ENSG00000237238

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000443754 ENSG00000237238 HEK293_OSMI2_2hA HEK293_TMG_2hB BMS1P10 transcribed_unprocessed_pseudogene transcribed_unprocessed_pseudogene 1.419294 1.870126 1.347384 0.5353138 0.09123993 -0.4700011 0.06481473 0.0152618 0.1588104 0.01526180 0.09187195 2.7403742 0.0481125 0.0180 0.1132333 0.09523333 0.30579594 0.02275001 TRUE TRUE
ENST00000647845 ENSG00000237238 HEK293_OSMI2_2hA HEK293_TMG_2hB BMS1P10 transcribed_unprocessed_pseudogene processed_transcript 1.419294 1.870126 1.347384 0.5353138 0.09123993 -0.4700011 0.15111019 0.1189951 0.1331982 0.06304835 0.09891454 0.1506972 0.1179792 0.0518 0.1032333 0.05143333 0.94279698 0.02275001 TRUE TRUE
MSTRG.32772.3 ENSG00000237238 HEK293_OSMI2_2hA HEK293_TMG_2hB BMS1P10 transcribed_unprocessed_pseudogene   1.419294 1.870126 1.347384 0.5353138 0.09123993 -0.4700011 1.20336893 1.7358695 1.0553750 0.50031310 0.07372919 -0.7125843 0.8339125 0.9302 0.7835333 -0.14666667 0.02275001 0.02275001   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000237238 E001 0.7675920 0.019879791 0.541702803 0.67264855 9 63299453 63299620 168 - 0.310 0.207 -0.776
ENSG00000237238 E002 0.6997360 0.017267182 0.049333978 0.10797710 9 63309142 63309312 171 - 0.000 0.346 10.391
ENSG00000237238 E003 1.7766910 0.009132097 0.037812742 0.08698740 9 63372803 63372978 176 - 0.616 0.282 -1.777
ENSG00000237238 E004 1.9250859 0.008049906 0.003206239 0.01087349 9 63373321 63373468 148 - 0.683 0.207 -2.651
ENSG00000237238 E005 1.6316175 0.009454212 0.374362236 0.51877940 9 63374383 63374505 123 - 0.489 0.346 -0.775
ENSG00000237238 E006 0.4407149 0.024693219 0.492771589 0.62990270 9 63374872 63374969 98 - 0.229 0.115 -1.192
ENSG00000237238 E007 0.0000000       9 63375613 63375671 59 -      
ENSG00000237238 E008 1.1929789 0.015452781 0.564235087 0.69155877 9 63375918 63375947 30 - 0.379 0.282 -0.603
ENSG00000237238 E009 4.9884249 0.003857761 0.464168619 0.60392671 9 63375948 63376098 151 - 0.714 0.812 0.395
ENSG00000237238 E010 0.0000000       9 63376183 63376371 189 -      
ENSG00000237238 E011 7.9538363 0.002706566 0.109031269 0.20411525 9 63379123 63379294 172 - 0.839 1.006 0.630
ENSG00000237238 E012 3.9534044 0.005113274 0.462024001 0.60193412 9 63379940 63380009 70 - 0.616 0.722 0.449
ENSG00000237238 E013 1.8423649 0.009161708 0.497171823 0.63372297 9 63380010 63380011 2 - 0.378 0.496 0.617
ENSG00000237238 E014 0.9210820 0.196951438 0.589828197 0.71283057 9 63385079 63385117 39 - 0.229 0.340 0.774