ENSG00000237149

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000466942 ENSG00000237149 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF503-AS2 lncRNA lncRNA 8.793201 16.75083 4.401635 1.386254 0.2572535 -1.925708 1.5354970 2.849888 0.65781114 0.3041282 0.05197992 -2.098447 0.1852458 0.16976667 0.14923333 -0.02053333 7.476448e-01 6.287361e-07   FALSE
ENST00000484411 ENSG00000237149 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF503-AS2 lncRNA lncRNA 8.793201 16.75083 4.401635 1.386254 0.2572535 -1.925708 1.9657661 3.921232 1.19631603 0.3563046 0.39074774 -1.704373 0.2190000 0.23656667 0.26350000 0.02693333 9.602681e-01 6.287361e-07 FALSE FALSE
ENST00000486015 ENSG00000237149 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF503-AS2 lncRNA lncRNA 8.793201 16.75083 4.401635 1.386254 0.2572535 -1.925708 1.7453514 3.997471 0.23297131 0.5004442 0.06426982 -4.043834 0.1594542 0.23856667 0.05216667 -0.18640000 6.287361e-07 6.287361e-07   FALSE
ENST00000491557 ENSG00000237149 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF503-AS2 lncRNA lncRNA 8.793201 16.75083 4.401635 1.386254 0.2572535 -1.925708 2.8204017 4.708106 2.10128141 0.7512233 0.23688277 -1.160089 0.3410875 0.27736667 0.48613333 0.20876667 1.047785e-01 6.287361e-07 FALSE FALSE
ENST00000527641 ENSG00000237149 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF503-AS2 lncRNA lncRNA 8.793201 16.75083 4.401635 1.386254 0.2572535 -1.925708 0.4129887 0.668532 0.09580659 0.1466200 0.04841523 -2.680987 0.0529875 0.04133333 0.02206667 -0.01926667 5.955832e-01 6.287361e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000237149 E001 44.999292 0.0005505966 2.704875e-01 4.091556e-01 10 75401519 75402261 743 + 1.466 1.522 0.191
ENSG00000237149 E002 20.111139 0.0010663506 3.136655e-06 2.336452e-05 10 75402897 75403053 157 + 0.583 1.224 2.480
ENSG00000237149 E003 13.263975 0.0014939451 1.479571e-03 5.571241e-03 10 75403054 75403083 30 + 0.583 1.050 1.853
ENSG00000237149 E004 6.098339 0.0031936627 1.407810e-01 2.490855e-01 10 75403084 75403351 268 + 0.494 0.741 1.088
ENSG00000237149 E005 9.670363 0.0062576294 8.140478e-01 8.821633e-01 10 75403756 75403875 120 + 0.867 0.882 0.060
ENSG00000237149 E006 26.576351 0.0104294800 5.844917e-01 7.083967e-01 10 75403876 75403946 71 + 1.346 1.280 -0.231
ENSG00000237149 E007 31.436658 0.0008386581 2.088793e-02 5.335252e-02 10 75403947 75404057 111 + 1.516 1.325 -0.661
ENSG00000237149 E008 3.059113 0.0057760864 8.623038e-01 9.152023e-01 10 75404165 75404284 120 + 0.494 0.511 0.084
ENSG00000237149 E009 538.085434 0.0048792753 1.103975e-01 2.061168e-01 10 75407255 75408982 1728 + 2.613 2.578 -0.117