ENSG00000236753

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000416220 ENSG00000236753 HEK293_OSMI2_2hA HEK293_TMG_2hB MKLN1-AS lncRNA lncRNA 1.607809 1.629206 2.160333 0.1361154 0.06195146 0.4049197 0.39407274 0.63889712 0.3999548 0.01828875 0.21272896 -0.6625248 0.23911667 0.396233333 0.18886667 -0.20736667 0.49318493 0.01115572 FALSE FALSE
ENST00000444245 ENSG00000236753 HEK293_OSMI2_2hA HEK293_TMG_2hB MKLN1-AS lncRNA lncRNA 1.607809 1.629206 2.160333 0.1361154 0.06195146 0.4049197 0.07447870 0.00000000 0.0000000 0.00000000 0.00000000 0.0000000 0.05671667 0.000000000 0.00000000 0.00000000   0.01115572 FALSE FALSE
ENST00000447904 ENSG00000236753 HEK293_OSMI2_2hA HEK293_TMG_2hB MKLN1-AS lncRNA retained_intron 1.607809 1.629206 2.160333 0.1361154 0.06195146 0.4049197 0.09913977 0.08229605 0.2206452 0.03129334 0.04993684 1.3213345 0.06808750 0.050966667 0.10366667 0.05270000 0.32093076 0.01115572 FALSE FALSE
ENST00000454515 ENSG00000236753 HEK293_OSMI2_2hA HEK293_TMG_2hB MKLN1-AS lncRNA lncRNA 1.607809 1.629206 2.160333 0.1361154 0.06195146 0.4049197 0.37669264 0.61937489 0.5362268 0.09187281 0.19396264 -0.2044194 0.23347083 0.376900000 0.24820000 -0.12870000 0.53603726 0.01115572 FALSE FALSE
ENST00000648242 ENSG00000236753 HEK293_OSMI2_2hA HEK293_TMG_2hB MKLN1-AS lncRNA lncRNA 1.607809 1.629206 2.160333 0.1361154 0.06195146 0.4049197 0.09593031 0.01076435 0.1927930 0.01076435 0.04092577 3.2878270 0.05809583 0.006233333 0.08830000 0.08206667 0.01115572 0.01115572   FALSE
ENST00000656389 ENSG00000236753 HEK293_OSMI2_2hA HEK293_TMG_2hB MKLN1-AS lncRNA lncRNA 1.607809 1.629206 2.160333 0.1361154 0.06195146 0.4049197 0.13641038 0.20966030 0.1400127 0.02368800 0.02095025 -0.5501899 0.09019167 0.128033333 0.06546667 -0.06256667 0.24790246 0.01115572   FALSE
ENST00000669897 ENSG00000236753 HEK293_OSMI2_2hA HEK293_TMG_2hB MKLN1-AS lncRNA lncRNA 1.607809 1.629206 2.160333 0.1361154 0.06195146 0.4049197 0.21816748 0.00000000 0.4593505 0.00000000 0.45935051 5.5525938 0.12642500 0.000000000 0.20953333 0.20953333 0.89049477 0.01115572 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000236753 E001 1.0234820 0.0694663910 0.115802773 0.213952623 7 131309469 131309743 275 - 0.436 0.135 -2.238
ENSG00000236753 E002 0.1451727 0.0429825820 0.614098680   7 131309744 131309749 6 - 0.110 0.000 -11.974
ENSG00000236753 E003 0.3666179 0.0327380230 0.858472215 0.912689525 7 131309750 131309841 92 - 0.110 0.136 0.354
ENSG00000236753 E004 0.2214452 0.0548330291 0.386809647   7 131309842 131309870 29 - 0.000 0.136 11.317
ENSG00000236753 E005 0.3666179 0.0327380230 0.858472215 0.912689525 7 131309871 131309901 31 - 0.110 0.136 0.354
ENSG00000236753 E006 0.2903454 0.2527807255 0.349156090   7 131309902 131309912 11 - 0.197 0.000 -12.537
ENSG00000236753 E007 0.7675920 0.0151168185 0.849847563 0.906816797 7 131309913 131309926 14 - 0.271 0.239 -0.236
ENSG00000236753 E008 6.1308081 0.0064151438 0.176423514 0.296594215 7 131309927 131310773 847 - 0.929 0.762 -0.650
ENSG00000236753 E009 0.5451131 0.6060667234 0.208601161 0.336809458 7 131310774 131311129 356 - 0.000 0.325 12.148
ENSG00000236753 E010 1.2773193 0.4251871480 0.792544037 0.867349228 7 131311130 131311223 94 - 0.387 0.325 -0.366
ENSG00000236753 E011 13.3312565 0.0210345543 0.001425572 0.005391701 7 131311224 131314765 3542 - 0.958 1.313 1.276
ENSG00000236753 E012 1.1374321 0.0123392995 0.402878493 0.546683228 7 131321879 131321931 53 - 0.388 0.239 -0.970
ENSG00000236753 E013 3.2291539 0.0061762379 0.162155717 0.277925272 7 131322645 131322715 71 - 0.519 0.733 0.934
ENSG00000236753 E014 2.8356710 0.0054315615 0.647273274 0.758971441 7 131322716 131322765 50 - 0.620 0.553 -0.303
ENSG00000236753 E015 0.9684132 0.0229252156 0.160580532 0.275906947 7 131322766 131322767 2 - 0.388 0.136 -1.970
ENSG00000236753 E016 1.4101723 0.0102549917 0.508414741 0.643829992 7 131322768 131322786 19 - 0.436 0.323 -0.651
ENSG00000236753 E017 1.4080959 0.0337482859 0.526343840 0.659586190 7 131322787 131322796 10 - 0.436 0.322 -0.652
ENSG00000236753 E018 3.4613140 0.0053948140 0.176733213 0.296996265 7 131322797 131322842 46 - 0.749 0.552 -0.845
ENSG00000236753 E019 31.7960950 0.0009899585 0.065968659 0.136646634 7 131322843 131323364 522 - 1.462 1.568 0.365
ENSG00000236753 E020 31.6863595 0.0008308050 0.933539436 0.962124225 7 131323365 131323776 412 - 1.522 1.522 0.001
ENSG00000236753 E021 12.0391953 0.0015198321 0.504777576 0.640650357 7 131323777 131323868 92 - 1.088 1.153 0.234
ENSG00000236753 E022 0.1451727 0.0429825820 0.614098680   7 131323869 131324251 383 - 0.110 0.000 -11.974
ENSG00000236753 E023 1.6554637 0.0086482457 0.712830416 0.809424401 7 131324252 131324300 49 - 0.388 0.453 0.351
ENSG00000236753 E024 1.0320003 0.0415054991 0.617410796 0.735227596 7 131324301 131324302 2 - 0.333 0.240 -0.641
ENSG00000236753 E025 11.5975499 0.0015377887 0.602468639 0.723443481 7 131324303 131324425 123 - 1.077 1.130 0.189
ENSG00000236753 E026 12.5570993 0.0042248198 0.032941817 0.077689607 7 131326806 131326895 90 - 1.219 1.023 -0.706
ENSG00000236753 E027 7.6340910 0.0023761070 0.211637311 0.340423459 7 131326896 131326935 40 - 0.997 0.860 -0.517
ENSG00000236753 E028 2.1560961 0.0108143064 0.017725190 0.046541704 7 131326936 131327614 679 - 0.649 0.239 -2.235
ENSG00000236753 E029 9.4696883 0.0343013158 0.525734258 0.659070792 7 131327615 131327989 375 - 1.057 0.976 -0.298
ENSG00000236753 E030 1.8016816 0.0137486763 0.606081371 0.726327054 7 131327990 131328312 323 - 0.480 0.393 -0.455