ENSG00000236438

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000634862 ENSG00000236438 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM157A transcribed_unprocessed_pseudogene processed_transcript 11.73319 15.47604 7.587176 1.851408 0.3223916 -1.027433 1.2589733 1.2601525 1.2825898 0.29687985 0.2185014 0.02526285 0.12752083 0.08013333 0.16820000 0.08806667 6.915128e-02 1.233179e-09 FALSE  
MSTRG.24386.10 ENSG00000236438 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM157A transcribed_unprocessed_pseudogene   11.73319 15.47604 7.587176 1.851408 0.3223916 -1.027433 0.4374587 1.0368442 0.1148620 0.28477128 0.1148620 -3.06763991 0.03862500 0.06553333 0.01436667 -0.05116667 1.553070e-01 1.233179e-09 FALSE  
MSTRG.24386.11 ENSG00000236438 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM157A transcribed_unprocessed_pseudogene   11.73319 15.47604 7.587176 1.851408 0.3223916 -1.027433 0.7135661 1.3324312 0.3529114 0.02355928 0.1913424 -1.88715871 0.06710417 0.08836667 0.04726667 -0.04110000 5.980891e-01 1.233179e-09 FALSE  
MSTRG.24386.13 ENSG00000236438 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM157A transcribed_unprocessed_pseudogene   11.73319 15.47604 7.587176 1.851408 0.3223916 -1.027433 0.6096011 0.9718128 0.0000000 0.08672819 0.0000000 -6.61737614 0.04296250 0.06450000 0.00000000 -0.06450000 1.233179e-09 1.233179e-09 FALSE  
MSTRG.24386.14 ENSG00000236438 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM157A transcribed_unprocessed_pseudogene   11.73319 15.47604 7.587176 1.851408 0.3223916 -1.027433 7.3136998 9.3521580 4.9825540 1.18604293 0.1583697 -0.90706308 0.60339583 0.60343333 0.65830000 0.05486667 5.585342e-01 1.233179e-09 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000236438 E001 0.0000000       3 198153287 198153409 123 +      
ENSG00000236438 E002 2.1839932 0.085659299 0.105203233 0.19840164 3 198157123 198157669 547 + 0.667 0.362 -1.486
ENSG00000236438 E003 1.7756573 0.008475660 0.296035859 0.43720313 3 198167676 198167738 63 + 0.535 0.363 -0.891
ENSG00000236438 E004 3.4331854 0.025008547 0.044069170 0.09850942 3 198167739 198167871 133 + 0.796 0.492 -1.323
ENSG00000236438 E005 2.7270049 0.089395028 0.079697137 0.15907939 3 198169785 198170059 275 + 0.736 0.411 -1.495
ENSG00000236438 E006 0.0000000       3 198180753 198180754 2 +      
ENSG00000236438 E007 1.2835352 0.031409656 0.189007194 0.31249975 3 198180755 198180864 110 + 0.480 0.252 -1.362
ENSG00000236438 E008 0.5138669 0.021603109 0.335483518 0.47926943 3 198181927 198182058 132 + 0.257 0.101 -1.625
ENSG00000236438 E009 1.2073619 0.109238081 0.381918453 0.52617524 3 198185349 198185564 216 + 0.417 0.255 -1.017
ENSG00000236438 E010 0.2924217 0.028998596 0.103857958   3 198186449 198186514 66 + 0.257 0.000 -14.386
ENSG00000236438 E011 0.0000000       3 198188672 198188730 59 +      
ENSG00000236438 E012 0.4031496 0.024441170 0.353355585 0.49759651 3 198189837 198189929 93 + 0.000 0.183 12.579
ENSG00000236438 E013 1.1310007 0.018684879 0.822366440 0.88801345 3 198189930 198190195 266 + 0.345 0.311 -0.212
ENSG00000236438 E014 0.8020473 0.073568056 0.954573095 0.97552307 3 198190196 198190216 21 + 0.257 0.251 -0.044
ENSG00000236438 E015 0.5117019 0.022067070 0.179950078 0.30112268 3 198190217 198190288 72 + 0.000 0.252 13.060
ENSG00000236438 E016 0.0000000       3 198190289 198190366 78 +      
ENSG00000236438 E017 0.0000000       3 198198946 198199010 65 +      
ENSG00000236438 E018 0.0000000       3 198201234 198201423 190 +      
ENSG00000236438 E019 0.1451727 0.044054034 0.317135572   3 198205702 198205845 144 + 0.147 0.000 -13.558
ENSG00000236438 E020 0.3268771 0.028326466 0.737400987   3 198208264 198208387 124 + 0.147 0.101 -0.626
ENSG00000236438 E021 0.3299976 0.026466092 0.352970631   3 198210271 198210368 98 + 0.000 0.183 12.574
ENSG00000236438 E022 0.4782907 0.047890726 0.182805306 0.30472162 3 198210705 198210765 61 + 0.000 0.251 13.038
ENSG00000236438 E023 0.6599951 0.022862634 0.096657364 0.18535355 3 198210766 198210901 136 + 0.000 0.311 13.391
ENSG00000236438 E024 0.3299976 0.026466092 0.352970631   3 198211746 198211810 65 + 0.000 0.183 12.574
ENSG00000236438 E025 0.0000000       3 198213997 198214189 193 +      
ENSG00000236438 E026 0.1482932 0.047934135 0.728221401   3 198216072 198216262 191 + 0.000 0.101 11.698
ENSG00000236438 E027 0.5514428 0.020015928 0.178216938 0.29891303 3 198218324 198218381 58 + 0.000 0.252 13.063
ENSG00000236438 E028 0.5514428 0.020015928 0.178216938 0.29891303 3 198218475 198219138 664 + 0.000 0.252 13.063
ENSG00000236438 E029 0.0000000       3 198219139 198219293 155 +      
ENSG00000236438 E030 0.0000000       3 198219294 198219310 17 +      
ENSG00000236438 E031 0.0000000       3 198219311 198219314 4 +      
ENSG00000236438 E032 0.0000000       3 198219315 198219328 14 +      
ENSG00000236438 E033 0.0000000       3 198219329 198219788 460 +      
ENSG00000236438 E034 8.4051640 0.083111137 0.355640888 0.50001187 3 198219789 198219835 47 + 1.047 0.893 -0.573
ENSG00000236438 E035 3.6525622 0.006987307 0.193104506 0.31766891 3 198219836 198219932 97 + 0.480 0.694 0.962
ENSG00000236438 E036 2.6726226 0.007707908 0.006752689 0.02058071 3 198219933 198219980 48 + 0.147 0.645 3.078
ENSG00000236438 E037 13.5686478 0.001703013 0.714374897 0.81060016 3 198219981 198220029 49 + 1.157 1.133 -0.086
ENSG00000236438 E038 3.0736984 0.124752449 0.628678393 0.74417396 3 198220030 198220077 48 + 0.480 0.628 0.684
ENSG00000236438 E039 4.5871230 0.005062594 0.399518632 0.54326447 3 198220078 198220126 49 + 0.627 0.758 0.546
ENSG00000236438 E040 3.7978236 0.041142510 0.955543643 0.97609426 3 198220127 198220222 96 + 0.627 0.650 0.099
ENSG00000236438 E041 5.4521966 0.003368747 0.257196659 0.39425777 3 198220223 198220271 49 + 0.873 0.737 -0.539
ENSG00000236438 E042 3.9699921 0.142215125 0.791463498 0.86660882 3 198220272 198220417 146 + 0.735 0.645 -0.377
ENSG00000236438 E043 2.5725038 0.007279655 0.167239256 0.28460659 3 198220418 198220514 97 + 0.345 0.590 1.250
ENSG00000236438 E044 15.2103299 0.008513708 0.696287703 0.79668074 3 198220515 198220563 49 + 1.157 1.203 0.164
ENSG00000236438 E045 7.3290128 0.002552431 0.280823284 0.42069864 3 198220564 198220612 49 + 0.796 0.935 0.532
ENSG00000236438 E046 10.9721279 0.002322543 0.619983171 0.73726666 3 198220613 198220661 49 + 1.013 1.070 0.208
ENSG00000236438 E047 5.5273087 0.003110987 0.877136955 0.92509731 3 198220662 198220755 94 + 0.767 0.795 0.111
ENSG00000236438 E048 1.0320003 0.016249679 0.173613176 0.29288324 3 198220756 198220803 48 + 0.418 0.183 -1.624
ENSG00000236438 E049 2.5714466 0.007229290 0.425730331 0.56864598 3 198220804 198220852 49 + 0.418 0.559 0.699
ENSG00000236438 E050 3.3141456 0.006491044 0.326822959 0.47027027 3 198220853 198220949 97 + 0.480 0.645 0.755
ENSG00000236438 E051 0.4428904 0.382575195 0.453638853 0.59439033 3 198220950 198221046 97 + 0.000 0.190 12.414
ENSG00000236438 E052 0.4815130 0.021185012 0.856288878 0.91114608 3 198221047 198222513 1467 + 0.148 0.183 0.371