ENSG00000236404

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000424605 ENSG00000236404 HEK293_OSMI2_2hA HEK293_TMG_2hB VLDLR-AS1 lncRNA lncRNA 0.3514928 0.2940525 0.9597696 0.0842208 0.1268245 1.673322 0.103772994 0.2879792 0.000000000 0.08761805 0.000000000 -4.8971397 0.30440417 0.9702333 0.00000000 -0.97023333 4.343547e-08 4.343547e-08   FALSE
ENST00000447278 ENSG00000236404 HEK293_OSMI2_2hA HEK293_TMG_2hB VLDLR-AS1 lncRNA lncRNA 0.3514928 0.2940525 0.9597696 0.0842208 0.1268245 1.673322 0.004426584 0.0000000 0.000000000 0.00000000 0.000000000 0.0000000 0.06372500 0.0000000 0.00000000 0.00000000   4.343547e-08   FALSE
ENST00000453601 ENSG00000236404 HEK293_OSMI2_2hA HEK293_TMG_2hB VLDLR-AS1 lncRNA lncRNA 0.3514928 0.2940525 0.9597696 0.0842208 0.1268245 1.673322 0.020190025 0.0000000 0.043995828 0.00000000 0.043995828 2.4328479 0.05807500 0.0000000 0.04056667 0.04056667 1.000000e+00 4.343547e-08   FALSE
ENST00000653709 ENSG00000236404 HEK293_OSMI2_2hA HEK293_TMG_2hB VLDLR-AS1 lncRNA lncRNA 0.3514928 0.2940525 0.9597696 0.0842208 0.1268245 1.673322 0.004412896 0.0000000 0.000000000 0.00000000 0.000000000 0.0000000 0.06277917 0.0000000 0.00000000 0.00000000   4.343547e-08   FALSE
ENST00000657742 ENSG00000236404 HEK293_OSMI2_2hA HEK293_TMG_2hB VLDLR-AS1 lncRNA lncRNA 0.3514928 0.2940525 0.9597696 0.0842208 0.1268245 1.673322 0.006281254 0.0000000 0.009786553 0.00000000 0.009786553 0.9845203 0.06457917 0.0000000 0.00900000 0.00900000 1.000000e+00 4.343547e-08 TRUE FALSE
ENST00000691704 ENSG00000236404 HEK293_OSMI2_2hA HEK293_TMG_2hB VLDLR-AS1 lncRNA lncRNA 0.3514928 0.2940525 0.9597696 0.0842208 0.1268245 1.673322 0.187433190 0.0000000 0.867245569 0.00000000 0.110816486 6.4549089 0.34783750 0.0000000 0.90966667 0.90966667 1.648866e-05 4.343547e-08   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000236404 E001 0.0000000       9 2421597 2421604 8 -      
ENSG00000236404 E002 0.0000000       9 2421605 2421781 177 -      
ENSG00000236404 E003 0.1515154 0.069868734 1.00000000   9 2421782 2421925 144 - 0.084 0.000 -10.527
ENSG00000236404 E004 0.4418608 0.024822971 0.55516083 0.68403784 9 2421926 2422701 776 - 0.215 0.000 -12.337
ENSG00000236404 E005 0.0000000       9 2422702 2423768 1067 -      
ENSG00000236404 E006 0.0000000       9 2423769 2423813 45 -      
ENSG00000236404 E007 0.4375944 0.025657949 0.55158110 0.68100946 9 2423814 2424093 280 - 0.215 0.000 -12.337
ENSG00000236404 E008 0.2903454 0.112386746 1.00000000   9 2424094 2424111 18 - 0.154 0.000 -11.952
ENSG00000236404 E009 0.5827671 0.024450898 0.36445100 0.50881117 9 2424112 2424510 399 - 0.268 0.000 -12.605
ENSG00000236404 E010 0.1451727 0.047751611 1.00000000   9 2425397 2425536 140 - 0.084 0.000 -11.254
ENSG00000236404 E011 0.0000000       9 2425537 2425540 4 -      
ENSG00000236404 E012 0.0000000       9 2425541 2425957 417 -      
ENSG00000236404 E013 0.1515154 0.069868734 1.00000000   9 2493075 2493180 106 - 0.084 0.000 -11.255
ENSG00000236404 E014 0.0000000       9 2493181 2493239 59 -      
ENSG00000236404 E015 0.0000000       9 2493240 2493425 186 -      
ENSG00000236404 E016 0.1515154 0.069868734 1.00000000   9 2494180 2494302 123 - 0.084 0.000 -11.255
ENSG00000236404 E017 0.2966881 0.032649190 1.00000000   9 2503270 2503403 134 - 0.154 0.000 -11.953
ENSG00000236404 E018 0.0000000       9 2506359 2506418 60 -      
ENSG00000236404 E019 0.1451727 0.047751611 1.00000000   9 2506419 2506540 122 - 0.084 0.000 -11.254
ENSG00000236404 E020 0.1451727 0.047751611 1.00000000   9 2521903 2522046 144 - 0.084 0.000 -11.254
ENSG00000236404 E021 0.1451727 0.047751611 1.00000000   9 2523053 2523157 105 - 0.084 0.000 -11.254
ENSG00000236404 E022 0.0000000       9 2525538 2525717 180 -      
ENSG00000236404 E023 0.0000000       9 2530904 2531129 226 -      
ENSG00000236404 E024 5.5316718 0.003286226 0.45931903 0.59951092 9 2535652 2536015 364 - 0.816 0.776 -0.157
ENSG00000236404 E025 4.6866588 0.003982484 0.05853719 0.12412633 9 2536359 2536453 95 - 0.703 0.810 0.432
ENSG00000236404 E026 4.5694876 0.006172492 0.34719098 0.49136995 9 2539399 2539552 154 - 0.738 0.738 -0.003
ENSG00000236404 E027 0.0000000       9 2570622 2570760 139 -      
ENSG00000236404 E028 1.7906241 0.106765938 0.03508796 0.08181604 9 2621229 2621421 193 - 0.552 0.000 -13.653
ENSG00000236404 E029 0.0000000       9 2622100 2622457 358 -