ENSG00000236287

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000413761 ENSG00000236287 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBED5 protein_coding protein_coding 17.06377 5.765868 30.84871 0.564211 0.4523574 2.417568 11.400396 4.3575666 20.605067 0.49768551 0.3769348 2.238798 0.6929833 0.75540000 0.6680333 -0.08736667 3.182036e-01 1.736755e-07 FALSE TRUE
ENST00000432999 ENSG00000236287 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBED5 protein_coding protein_coding 17.06377 5.765868 30.84871 0.564211 0.4523574 2.417568 2.731347 1.0411034 4.478245 0.25938868 0.6475355 2.094247 0.1598042 0.18020000 0.1447000 -0.03550000 7.906390e-01 1.736755e-07 FALSE TRUE
ENST00000534690 ENSG00000236287 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBED5 protein_coding protein_coding 17.06377 5.765868 30.84871 0.564211 0.4523574 2.417568 2.478708 0.1838908 5.053472 0.05354988 0.4313700 4.706810 0.1178667 0.03083333 0.1640667 0.13323333 1.736755e-07 1.736755e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000236287 E001 0.1515154 0.0422486267 1.000000e+00   11 10812074 10813005 932 - 0.059 0.001 -6.824
ENSG00000236287 E002 0.6299079 0.0193297582 6.865062e-01 7.890200e-01 11 10813006 10815122 2117 - 0.158 0.236 0.714
ENSG00000236287 E003 0.4396707 0.0294557397 7.537319e-01 8.395691e-01 11 10823104 10823267 164 - 0.158 0.000 -9.980
ENSG00000236287 E004 1.1748942 0.1792592000 3.644729e-02 8.443382e-02 11 10825650 10826582 933 - 0.158 0.591 2.723
ENSG00000236287 E005 0.4470576 0.0228736924 4.801605e-01 6.184727e-01 11 10836984 10837067 84 - 0.112 0.236 1.296
ENSG00000236287 E006 0.4502799 0.0261599260 7.549951e-01 8.404722e-01 11 10838269 10838573 305 - 0.158 0.000 -10.026
ENSG00000236287 E007 2.4594867 0.1709438456 1.663445e-02 4.413157e-02 11 10849897 10850103 207 - 0.307 0.831 2.494
ENSG00000236287 E008 0.1472490 0.0429134505 1.000000e+00   11 10852704 10852705 2 - 0.059 0.000 -8.263
ENSG00000236287 E009 901.3996432 0.0004566518 4.648062e-33 9.751510e-31 11 10852706 10854618 1913 - 2.820 2.973 0.506
ENSG00000236287 E010 92.8202225 0.0036595232 5.452920e-01 6.756680e-01 11 10854619 10854667 49 - 1.877 1.857 -0.068
ENSG00000236287 E011 112.5515533 0.0082958019 2.426152e-02 6.035101e-02 11 10854668 10854736 69 - 1.976 1.852 -0.418
ENSG00000236287 E012 90.5027670 0.0007317373 8.457510e-04 3.422514e-03 11 10854737 10854766 30 - 1.888 1.730 -0.533
ENSG00000236287 E013 263.7299202 0.0001680110 3.322888e-07 3.045825e-06 11 10854767 10855081 315 - 2.345 2.215 -0.435
ENSG00000236287 E014 54.8824034 0.0004459230 4.812173e-01 6.194507e-01 11 10855082 10855086 5 - 1.653 1.625 -0.097
ENSG00000236287 E015 18.8278034 0.0009840024 6.706025e-01 7.770063e-01 11 10855087 10855118 32 - 1.191 1.246 0.193
ENSG00000236287 E016 25.1831348 0.0009817106 4.482823e-01 5.895861e-01 11 10855658 10855883 226 - 1.333 1.280 -0.187
ENSG00000236287 E017 107.8704953 0.0006466553 1.479569e-01 2.588946e-01 11 10856144 10856205 62 - 1.947 1.897 -0.168
ENSG00000236287 E018 91.6296279 0.0012777353 5.369758e-02 1.157228e-01 11 10856206 10856257 52 - 1.883 1.800 -0.281
ENSG00000236287 E019 48.0936395 0.0010049893 1.775450e-09 2.512352e-08 11 10857223 10857595 373 - 1.655 1.168 -1.687
ENSG00000236287 E020 36.3352330 0.0010319026 1.408633e-09 2.032455e-08 11 10857596 10857861 266 - 1.545 0.951 -2.100
ENSG00000236287 E021 126.8967066 0.0003299069 2.225055e-06 1.713327e-05 11 10857862 10858796 935 - 2.039 1.847 -0.644