ENSG00000236255

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000420330 ENSG00000236255 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.089887 1.468084 4.98539 0.1910304 0.1298442 1.756869 0.5315584 0.1601469 0.85514078 0.05018722 0.06132997 2.3461541 0.16186250 0.1044333 0.171133333 0.066700000 3.668639e-01 1.308756e-08   FALSE
ENST00000439955 ENSG00000236255 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.089887 1.468084 4.98539 0.1910304 0.1298442 1.756869 0.2657753 0.0000000 1.09080072 0.00000000 0.09454934 6.7824095 0.05672917 0.0000000 0.218900000 0.218900000 1.308756e-08 1.308756e-08 TRUE FALSE
ENST00000664381 ENSG00000236255 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.089887 1.468084 4.98539 0.1910304 0.1298442 1.756869 0.4103627 0.1960355 0.62031339 0.05206691 0.08939692 1.6131765 0.12809583 0.1290667 0.123700000 -0.005366667 9.033099e-01 1.308756e-08   FALSE
ENST00000668696 ENSG00000236255 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.089887 1.468084 4.98539 0.1910304 0.1298442 1.756869 1.2346669 0.9016524 1.65615455 0.09009670 0.07895911 0.8699665 0.43962083 0.6204000 0.332866667 -0.287533333 6.601583e-04 1.308756e-08 TRUE FALSE
MSTRG.19110.1 ENSG00000236255 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   3.089887 1.468084 4.98539 0.1910304 0.1298442 1.756869 0.2095952 0.0136718 0.03785234 0.01367180 0.03785234 1.0154199 0.06160417 0.0116000 0.007966667 -0.003633333 9.116697e-01 1.308756e-08 TRUE FALSE
MSTRG.19110.2 ENSG00000236255 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   3.089887 1.468084 4.98539 0.1910304 0.1298442 1.756869 0.4201446 0.1965774 0.72512854 0.03429232 0.03684018 1.8313142 0.13928333 0.1345000 0.145433333 0.010933333 9.491106e-01 1.308756e-08 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000236255 E001 3.136603 0.0050937868 5.441018e-02 1.169728e-01 2 117833719 117833770 52 + 0.671 0.320 -1.759
ENSG00000236255 E002 2.030503 0.0071199139 7.890869e-01 8.649914e-01 2 117833771 117833797 27 + 0.469 0.421 -0.247
ENSG00000236255 E003 17.827858 0.0010843406 3.162305e-03 1.074445e-02 2 117833937 117834549 613 + 1.310 1.034 -0.985
ENSG00000236255 E004 9.648317 0.0017507502 4.584555e-02 1.017527e-01 2 117835462 117835576 115 + 1.053 0.810 -0.916
ENSG00000236255 E005 6.878119 0.0024905582 1.739443e-01 2.933113e-01 2 117835577 117835616 40 + 0.913 0.729 -0.720
ENSG00000236255 E006 8.562728 0.0021419834 6.464040e-01 7.583183e-01 2 117836228 117836349 122 + 0.962 0.908 -0.202
ENSG00000236255 E007 4.864085 0.0034113301 4.690562e-01 6.083631e-01 2 117836350 117836384 35 + 0.706 0.810 0.419
ENSG00000236255 E008 9.083884 0.0021469323 3.936695e-01 5.375525e-01 2 117836385 117836500 116 + 1.005 0.908 -0.366
ENSG00000236255 E009 5.032442 0.0040594697 2.262091e-01 3.578529e-01 2 117836501 117836524 24 + 0.809 0.630 -0.735
ENSG00000236255 E010 3.096847 0.0053602549 8.873730e-01 9.320243e-01 2 117836525 117836654 130 + 0.592 0.571 -0.095
ENSG00000236255 E011 18.394819 0.0010629406 7.034310e-04 2.911450e-03 2 117836655 117836900 246 + 1.330 1.011 -1.138
ENSG00000236255 E012 12.840818 0.0019485856 5.581833e-02 1.193779e-01 2 117837658 117837743 86 + 1.164 0.963 -0.734
ENSG00000236255 E013 23.034347 0.0009006728 3.885643e-02 8.891776e-02 2 117837744 117837984 241 + 1.389 1.226 -0.571
ENSG00000236255 E014 33.656892 0.0064676796 5.778747e-01 7.030532e-01 2 117837985 117838351 367 + 1.490 1.528 0.130
ENSG00000236255 E015 45.272749 0.0005751838 1.325978e-04 6.702668e-04 2 117838352 117839181 830 + 1.565 1.757 0.652
ENSG00000236255 E016 4.773226 0.0045195779 6.681604e-02 1.380887e-01 2 117839182 117839206 25 + 0.653 0.907 1.017
ENSG00000236255 E017 30.784721 0.0008021709 2.533642e-14 7.850686e-13 2 117839207 117839974 768 + 1.276 1.731 1.565
ENSG00000236255 E018 11.856447 0.0024401260 6.700868e-01 7.766557e-01 2 117839975 117840331 357 + 1.095 1.055 -0.147
ENSG00000236255 E019 11.942605 0.0081030348 2.173818e-02 5.513472e-02 2 117840332 117841251 920 + 1.147 0.877 -0.996
ENSG00000236255 E020 11.185551 0.0044982302 1.091288e-01 2.042609e-01 2 117841252 117841658 407 + 1.095 0.908 -0.691