ENSG00000236088

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000623598 ENSG00000236088 HEK293_OSMI2_2hA HEK293_TMG_2hB COX10-DT lncRNA TEC 3.753065 2.307055 3.958504 0.225953 0.2222938 0.7763025 0.22905312 0.39754643 0.0000000 0.252614182 0.00000000 -5.3488925 0.08462500 0.15443333 0.0000 -0.15443333 0.08574483 0.04997553   FALSE
ENST00000656963 ENSG00000236088 HEK293_OSMI2_2hA HEK293_TMG_2hB COX10-DT lncRNA lncRNA 3.753065 2.307055 3.958504 0.225953 0.2222938 0.7763025 0.46494187 0.07648954 0.8431656 0.076489538 0.17526256 3.3022282 0.10872500 0.03203333 0.2098 0.17776667 0.04997553 0.04997553   FALSE
ENST00000659114 ENSG00000236088 HEK293_OSMI2_2hA HEK293_TMG_2hB COX10-DT lncRNA lncRNA 3.753065 2.307055 3.958504 0.225953 0.2222938 0.7763025 0.24206960 0.04628629 0.1364553 0.046286290 0.07234289 1.3796049 0.05749167 0.01940000 0.0360 0.01660000 0.79926171 0.04997553   FALSE
ENST00000660804 ENSG00000236088 HEK293_OSMI2_2hA HEK293_TMG_2hB COX10-DT lncRNA lncRNA 3.753065 2.307055 3.958504 0.225953 0.2222938 0.7763025 0.08552533 0.19055440 0.1117867 0.156125193 0.11178667 -0.7196374 0.02671667 0.09756667 0.0317 -0.06586667 0.69417953 0.04997553   FALSE
ENST00000661551 ENSG00000236088 HEK293_OSMI2_2hA HEK293_TMG_2hB COX10-DT lncRNA lncRNA 3.753065 2.307055 3.958504 0.225953 0.2222938 0.7763025 1.21830252 0.58963580 1.4387507 0.007918302 0.13400202 1.2726509 0.31234583 0.26056667 0.3641 0.10353333 0.25767562 0.04997553   FALSE
ENST00000662986 ENSG00000236088 HEK293_OSMI2_2hA HEK293_TMG_2hB COX10-DT lncRNA lncRNA 3.753065 2.307055 3.958504 0.225953 0.2222938 0.7763025 0.26154196 0.00000000 0.0000000 0.000000000 0.00000000 0.0000000 0.07328333 0.00000000 0.0000 0.00000000   0.04997553   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000236088 E001 0.0000000       17 13755574 13756729 1156 -      
ENSG00000236088 E002 0.4470576 0.0211307110 9.192894e-01 0.953003466 17 13776373 13776603 231 - 0.176 0.153 -0.247
ENSG00000236088 E003 0.1482932 0.0411597534 2.936649e-01   17 13776604 13776627 24 - 0.000 0.153 11.395
ENSG00000236088 E004 0.1482932 0.0411597534 2.936649e-01   17 13776628 13776631 4 - 0.000 0.153 11.395
ENSG00000236088 E005 0.1482932 0.0411597534 2.936649e-01   17 13776632 13776660 29 - 0.000 0.153 11.395
ENSG00000236088 E006 1.2188142 0.0119649128 1.592050e-01 0.274058080 17 13776661 13776826 166 - 0.243 0.493 1.488
ENSG00000236088 E007 0.7770552 0.0147275066 3.121237e-01 0.454650228 17 13776827 13776831 5 - 0.176 0.355 1.338
ENSG00000236088 E008 2.2863020 0.0065915718 3.400007e-01 0.483942601 17 13776832 13776879 48 - 0.440 0.598 0.755
ENSG00000236088 E009 7.4060970 0.0023204515 8.248535e-02 0.163427405 17 13776880 13777176 297 - 0.830 1.030 0.755
ENSG00000236088 E010 5.3069026 0.0628169428 6.781074e-01 0.782662304 17 13777177 13777306 130 - 0.829 0.776 -0.213
ENSG00000236088 E011 3.3151832 0.0572796561 7.306133e-01 0.822503275 17 13777307 13777349 43 - 0.653 0.597 -0.244
ENSG00000236088 E012 1.6209197 0.0088272601 1.522738e-01 0.264780322 17 13777476 13777658 183 - 0.301 0.548 1.339
ENSG00000236088 E013 1.2533463 0.0107320389 4.615673e-01 0.601500538 17 13790269 13790313 45 - 0.398 0.266 -0.829
ENSG00000236088 E014 1.2125733 0.0118738955 9.954245e-01 1.000000000 17 13790314 13793577 3264 - 0.353 0.355 0.017
ENSG00000236088 E015 0.0000000       17 13865079 13865266 188 -      
ENSG00000236088 E016 1.9991934 0.0074026897 9.346001e-01 0.962802962 17 13880302 13880371 70 - 0.478 0.493 0.075
ENSG00000236088 E017 4.5854930 0.0067871502 8.801207e-01 0.927112743 17 13892725 13892839 115 - 0.741 0.719 -0.091
ENSG00000236088 E018 1.3412746 0.0105444498 7.878796e-02 0.157568436 17 13892840 13892842 3 - 0.478 0.153 -2.246
ENSG00000236088 E019 0.9922594 0.0134413213 8.450147e-01 0.903585308 17 13898609 13898732 124 - 0.301 0.266 -0.243
ENSG00000236088 E020 0.5212538 0.0199456341 3.086459e-01 0.450916020 17 14028676 14028709 34 - 0.097 0.266 1.755
ENSG00000236088 E021 0.9662351 0.0132817119 5.346086e-01 0.666635915 17 14028710 14028740 31 - 0.243 0.356 0.754
ENSG00000236088 E022 1.1145283 0.0132965799 2.985583e-01 0.440015587 17 14028741 14028765 25 - 0.243 0.430 1.168
ENSG00000236088 E023 2.9695801 0.1057297003 3.930527e-01 0.536930928 17 14028766 14028890 125 - 0.513 0.709 0.868
ENSG00000236088 E024 2.5173137 0.0061912696 9.934602e-01 1.000000000 17 14028891 14028896 6 - 0.545 0.548 0.017
ENSG00000236088 E025 3.5973997 0.0048151952 8.651447e-01 0.917118723 17 14028897 14028901 5 - 0.654 0.681 0.116
ENSG00000236088 E026 14.9525820 0.0017266024 3.608209e-05 0.000210224 17 14028902 14029291 390 - 1.022 1.377 1.260
ENSG00000236088 E027 12.6182572 0.0212214141 3.634766e-04 0.001632594 17 14029292 14029629 338 - 0.918 1.331 1.489
ENSG00000236088 E028 54.0340817 0.0005073371 1.383978e-01 0.245860380 17 14029630 14030571 942 - 1.708 1.776 0.229
ENSG00000236088 E029 14.6969391 0.0012405369 3.186808e-01 0.461645920 17 14030572 14030756 185 - 1.155 1.243 0.312
ENSG00000236088 E030 6.6136146 0.0026763695 2.422330e-01 0.376827140 17 14030757 14030788 32 - 0.814 0.956 0.543
ENSG00000236088 E031 13.1945010 0.0120800377 4.851288e-01 0.623075965 17 14030789 14031093 305 - 1.115 1.186 0.254
ENSG00000236088 E032 20.5382883 0.0010484988 4.470438e-01 0.588471936 17 14031094 14031639 546 - 1.348 1.292 -0.195
ENSG00000236088 E033 55.7701275 0.0010396867 8.722065e-03 0.025591938 17 14031640 14033551 1912 - 1.793 1.673 -0.407
ENSG00000236088 E034 13.6666591 0.0013508828 1.226540e-01 0.223739098 17 14033552 14033661 110 - 1.218 1.079 -0.500
ENSG00000236088 E035 19.1168241 0.0010624260 1.006358e-03 0.003980446 17 14033662 14033939 278 - 1.390 1.123 -0.942
ENSG00000236088 E036 7.0127951 0.0028477440 1.278229e-02 0.035401388 17 14033940 14034007 68 - 1.001 0.682 -1.244
ENSG00000236088 E037 40.3114509 0.0114001991 1.416883e-01 0.250344680 17 14034008 14034416 409 - 1.649 1.539 -0.375
ENSG00000236088 E038 16.4663486 0.0011727781 2.867127e-01 0.427130146 17 14069272 14069495 224 - 1.274 1.187 -0.308