ENSG00000236017

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000419737 ENSG00000236017 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 4.163753 2.579157 3.158797 0.7385461 0.285263 0.2914532 0.7144732 0.21671020 0.7284104 0.21671020 0.3932372 1.70357362 0.17651250 0.05346667 0.2131000 0.15963333 0.281137827 0.002289825 FALSE FALSE
ENST00000420411 ENSG00000236017 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 4.163753 2.579157 3.158797 0.7385461 0.285263 0.2914532 2.0304070 1.66164875 0.9443935 0.31661332 0.1628157 -0.80861562 0.49034167 0.67690000 0.2967000 -0.38020000 0.002289825 0.002289825 FALSE TRUE
ENST00000425740 ENSG00000236017 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 4.163753 2.579157 3.158797 0.7385461 0.285263 0.2914532 0.6921928 0.58308996 0.6166579 0.18148384 0.3207266 0.07942704 0.17219167 0.22360000 0.2130667 -0.01053333 0.856672049 0.002289825 FALSE TRUE
ENST00000443929 ENSG00000236017 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 4.163753 2.579157 3.158797 0.7385461 0.285263 0.2914532 0.6108956 0.06390195 0.3929863 0.06390195 0.2637660 2.44704647 0.11477917 0.01576667 0.1124667 0.09670000 0.566071812 0.002289825   FALSE
ENST00000602357 ENSG00000236017 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 4.163753 2.579157 3.158797 0.7385461 0.285263 0.2914532 0.1157839 0.05380578 0.4763494 0.05380578 0.2841096 2.93023400 0.04618333 0.03026667 0.1647000 0.13443333 0.574836910 0.002289825 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000236017 E001 6.835259 0.033099821 0.994806289 1.00000000 X 1401769 1401810 42 + 0.878 0.879 0.002
ENSG00000236017 E002 13.072050 0.001516763 0.309997213 0.45237009 X 1401811 1402042 232 + 1.178 1.091 -0.312
ENSG00000236017 E003 12.818758 0.013067544 0.376775117 0.52109386 X 1402043 1402225 183 + 1.072 1.167 0.344
ENSG00000236017 E004 2.284300 0.035462638 0.731406110 0.82306811 X 1403377 1403458 82 + 0.517 0.471 -0.224
ENSG00000236017 E005 1.180293 0.011474734 0.689581795 0.79143137 X 1403459 1403460 2 + 0.363 0.295 -0.430
ENSG00000236017 E006 10.978568 0.007191687 0.159669028 0.27467712 X 1403461 1403509 49 + 0.963 1.116 0.560
ENSG00000236017 E007 11.934107 0.001703013 0.290806175 0.43160704 X 1403510 1403585 76 + 1.034 1.135 0.364
ENSG00000236017 E008 9.694775 0.002146932 0.825629565 0.89021909 X 1412743 1412790 48 + 1.007 1.030 0.084
ENSG00000236017 E009 14.711286 0.001516763 0.344630069 0.48871672 X 1412791 1412888 98 + 1.139 1.219 0.284
ENSG00000236017 E010 12.855546 0.050466070 0.127742493 0.23101714 X 1412889 1413131 243 + 1.035 1.209 0.626
ENSG00000236017 E011 3.201928 0.095488358 0.006916017 0.02100777 X 1413749 1413761 13 + 0.818 0.299 -2.496
ENSG00000236017 E012 3.420151 0.043740475 0.024219417 0.06026447 X 1413762 1413763 2 + 0.796 0.420 -1.683
ENSG00000236017 E013 8.457506 0.002045784 0.008263680 0.02445184 X 1413764 1414028 265 + 1.095 0.813 -1.057