ENSG00000235706

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000435343 ENSG00000235706 HEK293_OSMI2_2hA HEK293_TMG_2hB DICER1-AS1 lncRNA lncRNA 2.030774 2.606321 1.213666 0.1745424 0.1976611 -1.09633 0.07297668 0.31291466 0.00000000 0.09304428 0.00000000 -5.0130810 0.03817083 0.12116667 0.00000000 -0.12116667 0.003105065 0.003105065 FALSE FALSE
ENST00000439819 ENSG00000235706 HEK293_OSMI2_2hA HEK293_TMG_2hB DICER1-AS1 lncRNA lncRNA 2.030774 2.606321 1.213666 0.1745424 0.1976611 -1.09633 0.17700178 0.08655159 0.20083359 0.08655159 0.06994823 1.1267328 0.09544167 0.03040000 0.15646667 0.12606667 0.171437967 0.003105065 FALSE FALSE
ENST00000439999 ENSG00000235706 HEK293_OSMI2_2hA HEK293_TMG_2hB DICER1-AS1 lncRNA lncRNA 2.030774 2.606321 1.213666 0.1745424 0.1976611 -1.09633 0.31352550 0.27435366 0.08574982 0.01509271 0.01091303 -1.5703447 0.13319167 0.10646667 0.07190000 -0.03456667 0.663422851 0.003105065 FALSE TRUE
ENST00000671073 ENSG00000235706 HEK293_OSMI2_2hA HEK293_TMG_2hB DICER1-AS1 lncRNA lncRNA 2.030774 2.606321 1.213666 0.1745424 0.1976611 -1.09633 1.06837754 1.60698834 0.67186807 0.04474295 0.02732516 -1.2457447 0.53155000 0.62003333 0.58246667 -0.03756667 0.842705494 0.003105065 FALSE FALSE
ENST00000693197 ENSG00000235706 HEK293_OSMI2_2hA HEK293_TMG_2hB DICER1-AS1 lncRNA lncRNA 2.030774 2.606321 1.213666 0.1745424 0.1976611 -1.09633 0.22824177 0.10428902 0.08470020 0.10428902 0.06089423 -0.2712475 0.11530000 0.03663333 0.06796667 0.03133333 0.722104241 0.003105065 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000235706 E001 0.2214452 0.0428418521 1.00000000   14 95157645 95157654 10 + 0.000 0.080 9.127
ENSG00000235706 E002 0.2214452 0.0428418521 1.00000000   14 95157655 95157655 1 + 0.000 0.080 10.944
ENSG00000235706 E003 0.6245948 0.1251531622 0.37219669 0.51665517 14 95157656 95157676 21 + 0.000 0.209 12.361
ENSG00000235706 E004 0.4031496 0.0287732655 0.61452542 0.73295264 14 95157677 95157677 1 + 0.000 0.148 11.919
ENSG00000235706 E005 0.4031496 0.0287732655 0.61452542 0.73295264 14 95157678 95157679 2 + 0.000 0.148 11.919
ENSG00000235706 E006 0.8772757 0.0510605461 0.58173872 0.70623485 14 95157680 95157684 5 + 0.311 0.207 -0.776
ENSG00000235706 E007 5.6304356 0.0033273060 0.49517109 0.63201470 14 95157685 95157705 21 + 0.829 0.737 -0.368
ENSG00000235706 E008 12.8924861 0.0025548857 0.43695733 0.57898413 14 95157706 95157741 36 + 1.132 1.055 -0.279
ENSG00000235706 E009 25.3675455 0.0012153058 0.01088448 0.03089209 14 95157742 95157858 117 + 1.481 1.302 -0.620
ENSG00000235706 E010 31.5167092 0.0007642136 0.01376116 0.03767901 14 95157859 95158192 334 + 1.563 1.410 -0.526
ENSG00000235706 E011 21.5061452 0.0057976621 0.57524215 0.70089491 14 95158193 95158234 42 + 1.330 1.286 -0.155
ENSG00000235706 E012 41.3564415 0.0005437559 0.90011093 0.94025803 14 95158235 95158788 554 + 1.569 1.564 -0.018
ENSG00000235706 E013 12.7209349 0.0014918556 0.06534307 0.13561129 14 95158789 95158818 30 + 0.920 1.125 0.754
ENSG00000235706 E014 13.7840821 0.0014671283 0.22385463 0.35501727 14 95158819 95158875 57 + 1.018 1.145 0.460
ENSG00000235706 E015 45.7713604 0.0005679895 0.65499748 0.76500947 14 95158876 95159035 160 + 1.587 1.614 0.090
ENSG00000235706 E016 17.8629848 0.0078513146 0.23786260 0.37166362 14 95177483 95179378 1896 + 1.115 1.232 0.417
ENSG00000235706 E017 21.8025653 0.0009004679 0.86526402 0.91719313 14 95179499 95179503 5 + 1.309 1.297 -0.040
ENSG00000235706 E018 54.6725553 0.0005667172 0.80175257 0.87368705 14 95179504 95179633 130 + 1.691 1.681 -0.035
ENSG00000235706 E019 46.0935091 0.0005621898 0.03831254 0.08793630 14 95179634 95179750 117 + 1.517 1.639 0.414
ENSG00000235706 E020 30.4738261 0.0007767359 0.45729295 0.59764466 14 95179751 95181475 1725 + 1.399 1.452 0.184