ENSG00000235257

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000366441 ENSG00000235257 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA9-AS1 lncRNA lncRNA 3.558318 3.942136 3.872844 0.4248244 0.1495002 -0.02551861 1.2930600 1.81759489 1.2188057 0.19886179 0.24246336 -0.57268948 0.36599583 0.470166667 0.31103333 -0.15913333 3.159981e-01 6.088532e-06   FALSE
ENST00000445429 ENSG00000235257 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA9-AS1 lncRNA lncRNA 3.558318 3.942136 3.872844 0.4248244 0.1495002 -0.02551861 0.4857482 0.29329305 0.3042853 0.15252076 0.18241709 0.05136254 0.13088333 0.070266667 0.08153333 0.01126667 1.000000e+00 6.088532e-06   FALSE
ENST00000450990 ENSG00000235257 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA9-AS1 lncRNA lncRNA 3.558318 3.942136 3.872844 0.4248244 0.1495002 -0.02551861 0.1154090 0.03816356 0.5000561 0.03816356 0.05191734 3.40464191 0.03335000 0.007966667 0.12850000 0.12053333 6.088532e-06 6.088532e-06   FALSE
ENST00000457661 ENSG00000235257 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA9-AS1 lncRNA lncRNA 3.558318 3.942136 3.872844 0.4248244 0.1495002 -0.02551861 0.1041158 0.00000000 0.3898557 0.00000000 0.12579821 5.32140745 0.03165833 0.000000000 0.10070000 0.10070000 7.048749e-05 6.088532e-06   FALSE
ENST00000660689 ENSG00000235257 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA9-AS1 lncRNA lncRNA 3.558318 3.942136 3.872844 0.4248244 0.1495002 -0.02551861 0.2705612 0.30648464 0.2476382 0.06596564 0.04760283 -0.29678872 0.07626667 0.080666667 0.06390000 -0.01676667 8.717681e-01 6.088532e-06   FALSE
ENST00000684787 ENSG00000235257 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA9-AS1 lncRNA lncRNA 3.558318 3.942136 3.872844 0.4248244 0.1495002 -0.02551861 0.1857695 0.24675705 0.0000000 0.24675705 0.00000000 -4.68233201 0.05075833 0.051500000 0.00000000 -0.05150000 7.617606e-01 6.088532e-06   FALSE
ENST00000686387 ENSG00000235257 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA9-AS1 lncRNA lncRNA 3.558318 3.942136 3.872844 0.4248244 0.1495002 -0.02551861 0.5285794 0.66113370 0.4025081 0.31773144 0.24089055 -0.70217778 0.14128333 0.172866667 0.10836667 -0.06450000 8.088654e-01 6.088532e-06   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000235257 E001 0.1451727 0.042440746 0.4699163717   3 37693655 37693931 277 - 0.127 0.000 -10.583
ENSG00000235257 E002 0.1451727 0.042440746 0.4699163717   3 37693932 37694429 498 - 0.127 0.000 -12.962
ENSG00000235257 E003 0.0000000       3 37694430 37694661 232 -      
ENSG00000235257 E004 0.0000000       3 37716907 37717867 961 -      
ENSG00000235257 E005 0.0000000       3 37717868 37719087 1220 -      
ENSG00000235257 E006 0.1451727 0.042440746 0.4699163717   3 37719088 37720419 1332 - 0.127 0.000 -12.962
ENSG00000235257 E007 0.0000000       3 37728430 37728530 101 -      
ENSG00000235257 E008 0.2924217 0.029078516 0.1883350542   3 37745432 37745959 528 - 0.225 0.000 -13.806
ENSG00000235257 E009 0.5890081 0.019981309 0.9453156651 0.969677269 3 37747847 37748783 937 - 0.225 0.210 -0.121
ENSG00000235257 E010 0.0000000       3 37748784 37748879 96 -      
ENSG00000235257 E011 0.0000000       3 37748880 37749069 190 -      
ENSG00000235257 E012 0.0000000       3 37749070 37749077 8 -      
ENSG00000235257 E013 0.0000000       3 37749078 37749275 198 -      
ENSG00000235257 E014 0.0000000       3 37749276 37749303 28 -      
ENSG00000235257 E015 0.1451727 0.042440746 0.4699163717   3 37749304 37749535 232 - 0.127 0.000 -12.962
ENSG00000235257 E016 0.2924217 0.029078516 0.1883350542   3 37749536 37749664 129 - 0.225 0.000 -13.806
ENSG00000235257 E017 0.0000000       3 37749665 37749688 24 -      
ENSG00000235257 E018 0.4502799 0.061498847 0.0809434942 0.161010743 3 37749689 37751330 1642 - 0.305 0.000 -14.220
ENSG00000235257 E019 0.1515154 0.044152291 0.4679752046   3 37753689 37753928 240 - 0.127 0.000 -12.960
ENSG00000235257 E020 0.7394793 0.015378759 0.1496182110 0.261155020 3 37753929 37754052 124 - 0.372 0.118 -2.119
ENSG00000235257 E021 0.0000000       3 37754053 37754053 1 -      
ENSG00000235257 E022 0.8846520 0.013643605 0.0784311617 0.156969208 3 37790751 37790842 92 - 0.431 0.118 -2.441
ENSG00000235257 E023 2.3981678 0.006220829 0.0010612187 0.004170706 3 37790843 37790911 69 - 0.759 0.211 -2.926
ENSG00000235257 E024 2.0368459 0.008005870 0.0372734900 0.085988198 3 37793680 37794823 1144 - 0.643 0.287 -1.855
ENSG00000235257 E025 0.2987644 0.030193742 0.1872044419   3 37794824 37794885 62 - 0.225 0.000 -13.805
ENSG00000235257 E026 1.1802934 0.011784863 0.6525386423 0.763211756 3 37794886 37795822 937 - 0.372 0.287 -0.531
ENSG00000235257 E027 0.9179615 0.013910980 0.9362438413 0.963896849 3 37795823 37796375 553 - 0.305 0.287 -0.120
ENSG00000235257 E028 15.6685593 0.001350883 0.0028745934 0.009896113 3 37803558 37804062 505 - 1.074 1.315 0.858
ENSG00000235257 E029 3.3108533 0.006699657 0.9410741498 0.966946569 3 37804063 37804710 648 - 0.642 0.647 0.018
ENSG00000235257 E030 1.8122777 0.008073032 0.3175803534 0.460477703 3 37804711 37805606 896 - 0.528 0.352 -0.924
ENSG00000235257 E031 1.0027668 0.014063134 0.4606845639 0.600672480 3 37805829 37806077 249 - 0.225 0.352 0.881
ENSG00000235257 E032 0.1515154 0.044152291 0.4679752046   3 37806078 37806078 1 - 0.127 0.000 -12.960
ENSG00000235257 E033 6.8924456 0.002591873 0.5084712722 0.643876003 3 37806079 37806185 107 - 0.944 0.860 -0.320
ENSG00000235257 E034 5.9031918 0.003308083 0.5331871498 0.665424054 3 37806186 37806228 43 - 0.808 0.878 0.272
ENSG00000235257 E035 1.5832421 0.027908604 0.6197217359 0.737057554 3 37806229 37808467 2239 - 0.372 0.457 0.462
ENSG00000235257 E036 0.1817044 0.040754408 0.5089161443   3 37808468 37808494 27 - 0.000 0.118 11.658
ENSG00000235257 E037 0.1817044 0.040754408 0.5089161443   3 37808495 37808495 1 - 0.000 0.118 11.658
ENSG00000235257 E038 0.1817044 0.040754408 0.5089161443   3 37808496 37808500 5 - 0.000 0.118 11.658
ENSG00000235257 E039 0.3268771 0.028474318 0.9710674293   3 37808501 37808703 203 - 0.127 0.118 -0.117
ENSG00000235257 E040 13.4703717 0.001486796 0.3903807522 0.534348652 3 37808704 37808880 177 - 1.211 1.130 -0.289
ENSG00000235257 E041 17.8115497 0.001262181 0.0003023484 0.001389154 3 37818277 37818679 403 - 1.098 1.376 0.984
ENSG00000235257 E042 12.8956256 0.026951084 0.1928594840 0.317362287 3 37818680 37818809 130 - 1.061 1.200 0.500
ENSG00000235257 E043 16.5546389 0.001526861 0.7734756121 0.853846190 3 37818810 37818930 121 - 1.237 1.252 0.051
ENSG00000235257 E044 0.2998086 0.028720147 0.9663627737   3 37820916 37821013 98 - 0.127 0.118 -0.121
ENSG00000235257 E045 16.4556435 0.001520198 0.1492596499 0.260658846 3 37821014 37821100 87 - 1.308 1.186 -0.428
ENSG00000235257 E046 0.0000000       3 37821101 37821410 310 -      
ENSG00000235257 E047 2.0596560 0.110133737 0.0648393561 0.134774544 3 37832765 37832938 174 - 0.225 0.589 2.085
ENSG00000235257 E048 19.3337171 0.001567649 0.7370516211 0.827336694 3 37834679 37834767 89 - 1.322 1.289 -0.118
ENSG00000235257 E049 0.5503986 0.022046258 0.6003250018 0.721566923 3 37834768 37835163 396 - 0.127 0.211 0.885
ENSG00000235257 E050 5.9983063 0.009738102 0.1123408587 0.208966770 3 37851424 37851446 23 - 0.944 0.731 -0.831
ENSG00000235257 E051 7.3279502 0.004514370 0.2202065203 0.350675963 3 37851447 37851492 46 - 0.992 0.841 -0.569
ENSG00000235257 E052 0.4751703 0.021768165 0.6038566791 0.724529344 3 37860178 37860470 293 - 0.127 0.211 0.881
ENSG00000235257 E053 11.3655072 0.024887344 0.6906136498 0.792265254 3 37861701 37861802 102 - 1.121 1.065 -0.200