ENSG00000234616

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000612905 ENSG00000234616 HEK293_OSMI2_2hA HEK293_TMG_2hB JRK protein_coding protein_coding 11.52556 13.94357 7.716552 0.5952264 0.2567723 -0.8527378 6.4130136 4.558651 5.8297826 0.3824434 0.3725997 0.3541465 0.60435417 0.3258000 0.75756667 0.43176667 4.471023e-05 4.471023e-05 FALSE TRUE
ENST00000614134 ENSG00000234616 HEK293_OSMI2_2hA HEK293_TMG_2hB JRK protein_coding protein_coding 11.52556 13.94357 7.716552 0.5952264 0.2567723 -0.8527378 3.7193327 6.874546 0.9574163 0.7854680 0.4802381 -2.8311528 0.27620833 0.4899667 0.12256667 -0.36740000 2.331740e-01 4.471023e-05 FALSE TRUE
MSTRG.32172.4 ENSG00000234616 HEK293_OSMI2_2hA HEK293_TMG_2hB JRK protein_coding   11.52556 13.94357 7.716552 0.5952264 0.2567723 -0.8527378 0.8138174 1.901655 0.4142227 0.6475604 0.1810302 -2.1719289 0.06602917 0.1409000 0.05443333 -0.08646667 3.234296e-01 4.471023e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000234616 E001 1.0997650 0.0121989077 3.572906e-01 5.016908e-01 8 142657460 142657462 3 - 0.164 0.333 1.325
ENSG00000234616 E002 155.4670045 0.0128987120 1.409472e-07 1.391890e-06 8 142657463 142657759 297 - 1.886 2.229 1.150
ENSG00000234616 E003 283.8282956 0.0097575018 5.640073e-07 4.940560e-06 8 142657760 142658080 321 - 2.212 2.475 0.876
ENSG00000234616 E004 227.5707530 0.0027421439 8.848285e-12 1.859642e-10 8 142658081 142658363 283 - 2.125 2.375 0.832
ENSG00000234616 E005 234.5184289 0.0001854678 1.612347e-12 3.816270e-11 8 142658364 142658821 458 - 2.188 2.370 0.607
ENSG00000234616 E006 134.5686909 0.0002638991 1.172373e-04 6.011872e-04 8 142658822 142658944 123 - 1.994 2.121 0.426
ENSG00000234616 E007 188.9358895 0.0002439644 4.402732e-01 5.819491e-01 8 142658945 142659297 353 - 2.219 2.237 0.058
ENSG00000234616 E008 124.2279368 0.0015050442 9.973953e-01 1.000000e+00 8 142659298 142659461 164 - 2.054 2.051 -0.011
ENSG00000234616 E009 942.5076697 0.0011653895 5.371505e-05 3.002879e-04 8 142659462 142663125 3664 - 2.973 2.912 -0.205
ENSG00000234616 E010 295.7399657 0.0041129353 3.651903e-05 2.124691e-04 8 142663126 142664477 1352 - 2.524 2.381 -0.478
ENSG00000234616 E011 320.3233930 0.0070057049 5.827041e-04 2.469941e-03 8 142664478 142665981 1504 - 2.556 2.418 -0.459
ENSG00000234616 E012 96.3863435 0.0005911155 1.192816e-11 2.451516e-10 8 142665982 142666327 346 - 2.106 1.848 -0.866
ENSG00000234616 E013 45.8461812 0.0004932642 4.226945e-07 3.794457e-06 8 142666328 142666414 87 - 1.797 1.528 -0.915
ENSG00000234616 E014 28.0941089 0.0007382689 3.479661e-04 1.571992e-03 8 142666415 142666456 42 - 1.578 1.337 -0.829
ENSG00000234616 E015 27.1589099 0.0031570440 2.095404e-04 1.004745e-03 8 142666457 142666520 64 - 1.583 1.318 -0.914
ENSG00000234616 E016 15.4056934 0.0207595469 4.120825e-02 9.326427e-02 8 142669932 142669940 9 - 1.327 1.103 -0.795
ENSG00000234616 E017 15.8100045 0.0160582353 6.038306e-03 1.871138e-02 8 142669941 142670132 192 - 1.372 1.087 -1.005
ENSG00000234616 E018 0.0000000       8 142675899 142676208 310 -      
ENSG00000234616 E019 0.0000000       8 142676355 142676531 177 -      
ENSG00000234616 E020 0.0000000       8 142676592 142676643 52 -      
ENSG00000234616 E021 0.0000000       8 142679974 142680145 172 -      
ENSG00000234616 E022 0.4031496 0.0241757605 4.545684e-01 5.951972e-01 8 142680146 142680884 739 - 0.000 0.165 8.647
ENSG00000234616 E023 0.0000000       8 142680885 142681137 253 -      
ENSG00000234616 E024 0.0000000       8 142681705 142681968 264 -