ENSG00000234608

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000428207 ENSG00000234608 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPKAPK5-AS1 lncRNA lncRNA 14.37566 16.22165 12.1267 1.454853 0.1106566 -0.4194338 5.945967 5.4788298 5.0060844 0.91364382 0.2273167 -0.1299370 0.40710417 0.33506667 0.41270000 0.0776333333 0.367604997 0.0003108901 TRUE TRUE
ENST00000442119 ENSG00000234608 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPKAPK5-AS1 lncRNA lncRNA 14.37566 16.22165 12.1267 1.454853 0.1106566 -0.4194338 2.600914 4.6076206 1.7702945 0.08780556 0.2362140 -1.3750338 0.18321667 0.28786667 0.14633333 -0.1415333333 0.005080698 0.0003108901 TRUE FALSE
ENST00000456429 ENSG00000234608 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPKAPK5-AS1 lncRNA lncRNA 14.37566 16.22165 12.1267 1.454853 0.1106566 -0.4194338 1.338760 2.2110327 1.5487947 0.42276663 0.1179261 -0.5107997 0.09311250 0.13500000 0.12756667 -0.0074333333 0.954525974 0.0003108901 TRUE TRUE
ENST00000652940 ENSG00000234608 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPKAPK5-AS1 lncRNA lncRNA 14.37566 16.22165 12.1267 1.454853 0.1106566 -0.4194338 1.133486 0.7361348 0.6021915 0.36814164 0.3547348 -0.2854531 0.08184167 0.04966667 0.04933333 -0.0003333333 1.000000000 0.0003108901   FALSE
ENST00000692189 ENSG00000234608 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPKAPK5-AS1 lncRNA lncRNA 14.37566 16.22165 12.1267 1.454853 0.1106566 -0.4194338 1.401486 1.2845237 1.3802948 0.17408677 0.2003886 0.1029695 0.09826250 0.07966667 0.11410000 0.0344333333 0.441413703 0.0003108901 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000234608 E001 0.000000       12 111839758 111839762 5 -      
ENSG00000234608 E002 0.000000       12 111839763 111839763 1 -      
ENSG00000234608 E003 0.000000       12 111839764 111839767 4 -      
ENSG00000234608 E004 1.990556 0.0076760537 1.176993e-01 2.166621e-01 12 111839768 111839772 5 - 0.264 0.548 1.595
ENSG00000234608 E005 17.190213 0.0015176967 9.230643e-02 1.787232e-01 12 111839773 111839782 10 - 1.145 1.294 0.528
ENSG00000234608 E006 17.335386 0.0018402767 1.245220e-01 2.264337e-01 12 111839783 111839783 1 - 1.158 1.294 0.482
ENSG00000234608 E007 30.657439 0.0200719959 1.038926e-01 1.964423e-01 12 111839784 111839806 23 - 1.365 1.533 0.577
ENSG00000234608 E008 131.564136 0.0022487756 8.579515e-04 3.465848e-03 12 111839807 111839909 103 - 2.015 2.143 0.428
ENSG00000234608 E009 211.017671 0.0001863133 3.785616e-06 2.769866e-05 12 111839910 111840003 94 - 2.227 2.343 0.388
ENSG00000234608 E010 47.080134 0.0005600376 4.037906e-03 1.324829e-02 12 111840004 111840031 28 - 1.558 1.717 0.539
ENSG00000234608 E011 41.170565 0.0014093602 2.181897e-02 5.529966e-02 12 111840032 111840042 11 - 1.516 1.655 0.474
ENSG00000234608 E012 74.724021 0.0041621029 2.074465e-01 3.354397e-01 12 111840043 111840133 91 - 1.815 1.885 0.234
ENSG00000234608 E013 97.969479 0.0003261644 7.555622e-02 1.524036e-01 12 111840134 111840332 199 - 2.018 1.957 -0.207
ENSG00000234608 E014 219.721428 0.0014866684 2.474582e-02 6.135351e-02 12 111840333 111840477 145 - 2.280 2.340 0.201
ENSG00000234608 E015 38.319551 0.0115800251 1.237870e-04 6.311858e-04 12 111840478 111841326 849 - 1.740 1.446 -1.005
ENSG00000234608 E016 127.695215 0.0009956774 4.238373e-04 1.865843e-03 12 111841327 111841398 72 - 2.165 2.051 -0.382
ENSG00000234608 E017 122.550578 0.0019432677 5.173193e-05 2.903496e-04 12 111841399 111841470 72 - 2.166 2.022 -0.484
ENSG00000234608 E018 172.973903 0.0002604701 2.348712e-09 3.251180e-08 12 111841471 111841683 213 - 2.317 2.162 -0.520
ENSG00000234608 E019 260.023634 0.0045354981 7.486219e-01 8.357937e-01 12 111841684 111842902 1219 - 2.393 2.392 -0.002