ENSG00000234420

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000452075 ENSG00000234420 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF37BP transcribed_processed_pseudogene processed_transcript 5.563608 1.691186 8.217074 0.2822036 0.3948992 2.273839 3.0404025 1.3356708 3.6244914 0.20804076 0.110606531 1.433428 0.61094167 0.79230000 0.4424667 -0.34983333 1.138269e-07 1.138269e-07 FALSE FALSE
ENST00000452306 ENSG00000234420 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF37BP transcribed_processed_pseudogene transcribed_processed_pseudogene 5.563608 1.691186 8.217074 0.2822036 0.3948992 2.273839 0.6052541 0.0000000 1.3553283 0.00000000 0.362983666 7.093104 0.07612500 0.00000000 0.1615667 0.16156667 5.099465e-05 1.138269e-07 FALSE FALSE
ENST00000473592 ENSG00000234420 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF37BP transcribed_processed_pseudogene processed_transcript 5.563608 1.691186 8.217074 0.2822036 0.3948992 2.273839 0.3357703 0.1157720 0.4789911 0.03256792 0.007875969 1.958997 0.06141667 0.06920000 0.0586000 -0.01060000 8.343244e-01 1.138269e-07 TRUE FALSE
ENST00000687308 ENSG00000234420 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF37BP transcribed_processed_pseudogene processed_transcript 5.563608 1.691186 8.217074 0.2822036 0.3948992 2.273839 0.5290402 0.1767184 0.9840838 0.10325429 0.238456203 2.412503 0.08267083 0.09723333 0.1229000 0.02566667 8.678855e-01 1.138269e-07 FALSE FALSE
MSTRG.3825.23 ENSG00000234420 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF37BP transcribed_processed_pseudogene   5.563608 1.691186 8.217074 0.2822036 0.3948992 2.273839 0.3209495 0.0000000 0.8418855 0.00000000 0.111343509 6.412588 0.04867917 0.00000000 0.1021333 0.10213333 6.343892e-05 1.138269e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000234420 E001 425.7066718 0.0053534138 1.235843e-10 2.148544e-09 10 42513510 42519694 6185 - 2.495 2.719 0.748
ENSG00000234420 E002 20.3792109 0.0010158588 9.652582e-02 1.851519e-01 10 42519695 42519799 105 - 1.281 1.191 -0.317
ENSG00000234420 E003 9.5012838 0.0018482017 3.633526e-02 8.421909e-02 10 42519800 42519802 3 - 1.002 0.782 -0.841
ENSG00000234420 E004 16.1557532 0.0011282579 3.611432e-02 8.380799e-02 10 42519803 42519867 65 - 1.202 1.046 -0.561
ENSG00000234420 E005 110.3956539 0.0062893557 3.836958e-02 8.804827e-02 10 42519868 42520786 919 - 1.989 1.949 -0.132
ENSG00000234420 E006 18.6173933 0.0010444752 9.820012e-02 1.877853e-01 10 42520787 42520820 34 - 1.250 1.154 -0.337
ENSG00000234420 E007 14.6187419 0.0018542152 1.029251e-01 1.949261e-01 10 42520821 42520822 2 - 1.159 1.046 -0.408
ENSG00000234420 E008 14.3168570 0.0015577726 7.275200e-02 1.479285e-01 10 42520823 42520826 4 - 1.154 1.020 -0.483
ENSG00000234420 E009 15.3519803 0.0016818321 3.202686e-02 7.591072e-02 10 42520827 42520827 1 - 1.188 1.020 -0.605
ENSG00000234420 E010 44.6152098 0.0005607936 3.342991e-03 1.127084e-02 10 42520828 42521127 300 - 1.619 1.496 -0.419
ENSG00000234420 E011 9.6149286 0.0017774898 9.044730e-01 9.431712e-01 10 42523182 42523209 28 - 0.948 1.020 0.266
ENSG00000234420 E012 24.1864120 0.0011092632 6.064345e-01 7.265777e-01 10 42523210 42523305 96 - 1.331 1.352 0.071
ENSG00000234420 E013 25.4927664 0.0050336872 2.963457e-01 4.375416e-01 10 42523612 42523738 127 - 1.367 1.339 -0.097
ENSG00000234420 E014 4.2449895 0.0039160821 5.310684e-01 6.635702e-01 10 42525540 42525660 121 - 0.671 0.619 -0.222
ENSG00000234420 E015 12.7022019 0.0014760883 1.398246e-01 2.477841e-01 10 42550557 42550577 21 - 1.099 0.993 -0.387
ENSG00000234420 E016 15.4097302 0.0011584597 5.780796e-02 1.228716e-01 10 42550578 42550615 38 - 1.183 1.046 -0.495
ENSG00000234420 E017 4.7630237 0.0033327345 3.144171e-01 4.571402e-01 10 42550616 42551388 773 - 0.729 0.619 -0.464
ENSG00000234420 E018 0.5975289 0.0263462228 3.131244e-01 4.556524e-01 10 42551389 42551399 11 - 0.223 0.000 -11.046
ENSG00000234420 E019 3.0270316 0.0051603432 1.214305e-01 2.219690e-01 10 42551400 42551462 63 - 0.604 0.355 -1.256
ENSG00000234420 E020 2.5311356 0.0158822134 5.490804e-03 1.726328e-02 10 42551463 42551572 110 - 0.586 0.000 -13.072
ENSG00000234420 E021 4.6595809 0.0060309107 5.801017e-01 7.049296e-01 10 42551573 42551576 4 - 0.715 0.680 -0.147
ENSG00000234420 E022 32.3896533 0.0007489772 2.139711e-02 5.442705e-02 10 42551577 42551814 238 - 1.482 1.376 -0.367
ENSG00000234420 E023 8.6841429 0.0020098503 3.042285e-01 4.462391e-01 10 42551815 42551858 44 - 0.940 0.864 -0.287
ENSG00000234420 E024 7.4599283 0.0025298334 2.469326e-01 3.823416e-01 10 42551859 42551989 131 - 0.887 0.782 -0.407
ENSG00000234420 E025 25.3715217 0.0007436164 2.368796e-02 5.916767e-02 10 42551990 42552280 291 - 1.383 1.257 -0.439
ENSG00000234420 E026 5.4262239 0.0030721903 1.024058e-01 1.941892e-01 10 42552281 42552378 98 - 0.655 0.934 1.108
ENSG00000234420 E027 1.5167355 0.0099154026 5.108381e-01 6.459943e-01 10 42552379 42552387 9 - 0.302 0.462 0.916
ENSG00000234420 E028 10.1913265 0.0016427665 7.025154e-01 8.013332e-01 10 42552388 42552451 64 - 0.980 0.993 0.050
ENSG00000234420 E029 11.3620549 0.0015746010 7.740047e-01 8.542670e-01 10 42552452 42552536 85 - 1.002 1.093 0.330
ENSG00000234420 E030 5.9232698 0.0157630497 9.727962e-01 9.870258e-01 10 42552537 42552542 6 - 0.768 0.826 0.229
ENSG00000234420 E031 6.3618964 0.0117722173 5.608429e-01 6.887543e-01 10 42552543 42552564 22 - 0.815 0.783 -0.127
ENSG00000234420 E032 5.4189559 0.0030188523 1.765911e-01 2.968207e-01 10 42552565 42552569 5 - 0.780 0.619 -0.670
ENSG00000234420 E033 8.7759970 0.0028397925 4.482326e-01 5.895329e-01 10 42552570 42552591 22 - 0.940 0.900 -0.150
ENSG00000234420 E034 7.3291914 0.0044694068 4.341735e-01 5.765698e-01 10 42552592 42552596 5 - 0.877 0.825 -0.201
ENSG00000234420 E035 9.5740325 0.0019415142 2.438867e-01 3.787615e-01 10 42552597 42552773 177 - 0.988 0.900 -0.327
ENSG00000234420 E036 3.0614739 0.0050131014 3.484934e-01 4.927245e-01 10 42552774 42552798 25 - 0.585 0.462 -0.588
ENSG00000234420 E037 0.8837216 0.1586935122 1.991063e-01 3.251060e-01 10 42552799 42552825 27 - 0.302 0.000 -11.085