ENSG00000234350

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000442456 ENSG00000234350 HEK293_OSMI2_2hA HEK293_TMG_2hB ERICH2-DT lncRNA lncRNA 0.35741 0.1604022 0.4191091 0.02659936 0.1002573 1.332401 0.061865509 0.03332317 0.06476878 0.01967212 0.04586150 0.7872973 0.215362500 0.1961667 0.16136667 -0.03480000 0.95605423 0.0053513   FALSE
ENST00000623667 ENSG00000234350 HEK293_OSMI2_2hA HEK293_TMG_2hB ERICH2-DT lncRNA lncRNA 0.35741 0.1604022 0.4191091 0.02659936 0.1002573 1.332401 0.051725343 0.05109813 0.01934132 0.02280955 0.01012959 -1.0581944 0.178620833 0.3036000 0.06756667 -0.23603333 0.06129086 0.0053513   FALSE
ENST00000661242 ENSG00000234350 HEK293_OSMI2_2hA HEK293_TMG_2hB ERICH2-DT lncRNA lncRNA 0.35741 0.1604022 0.4191091 0.02659936 0.1002573 1.332401 0.022943889 0.03260309 0.00000000 0.02468032 0.00000000 -2.0909579 0.095362500 0.1776667 0.00000000 -0.17766667 0.38204177 0.0053513 FALSE TRUE
ENST00000664115 ENSG00000234350 HEK293_OSMI2_2hA HEK293_TMG_2hB ERICH2-DT lncRNA lncRNA 0.35741 0.1604022 0.4191091 0.02659936 0.1002573 1.332401 0.004187772 0.00000000 0.03350218 0.00000000 0.03350218 2.1210876 0.008016667 0.0000000 0.06413333 0.06413333 0.98327540 0.0053513   FALSE
ENST00000666793 ENSG00000234350 HEK293_OSMI2_2hA HEK293_TMG_2hB ERICH2-DT lncRNA lncRNA 0.35741 0.1604022 0.4191091 0.02659936 0.1002573 1.332401 0.014777203 0.00000000 0.04773982 0.00000000 0.04773982 2.5295666 0.028270833 0.0000000 0.09140000 0.09140000 0.97678774 0.0053513   FALSE
ENST00000671292 ENSG00000234350 HEK293_OSMI2_2hA HEK293_TMG_2hB ERICH2-DT lncRNA lncRNA 0.35741 0.1604022 0.4191091 0.02659936 0.1002573 1.332401 0.085039974 0.00000000 0.20439235 0.00000000 0.05616217 4.4221815 0.151966667 0.0000000 0.47663333 0.47663333 0.00535130 0.0053513   FALSE
ENST00000689185 ENSG00000234350 HEK293_OSMI2_2hA HEK293_TMG_2hB ERICH2-DT lncRNA lncRNA 0.35741 0.1604022 0.4191091 0.02659936 0.1002573 1.332401 0.018757197 0.00000000 0.00000000 0.00000000 0.00000000 0.0000000 0.053179167 0.0000000 0.00000000 0.00000000   0.0053513   FALSE
ENST00000689466 ENSG00000234350 HEK293_OSMI2_2hA HEK293_TMG_2hB ERICH2-DT lncRNA lncRNA 0.35741 0.1604022 0.4191091 0.02659936 0.1002573 1.332401 0.063757022 0.04337781 0.04936465 0.02177227 0.02854083 0.1533641 0.200495833 0.3225000 0.13890000 -0.18360000 0.72291176 0.0053513   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000234350 E001 0.5954526 0.019494691 0.06483228 0.13476575 2 170700368 170700579 212 - 0.358 0.000 -13.465
ENSG00000234350 E002 0.0000000       2 170722864 170723085 222 -      
ENSG00000234350 E003 0.0000000       2 170723086 170723127 42 -      
ENSG00000234350 E004 0.0000000       2 170723128 170723134 7 -      
ENSG00000234350 E005 0.0000000       2 170723135 170723149 15 -      
ENSG00000234350 E006 0.1515154 0.056390128 0.67822760   2 170723150 170723191 42 - 0.121 0.000 -11.467
ENSG00000234350 E007 0.9296148 0.016081870 0.29130902 0.43216279 2 170723192 170723503 312 - 0.215 0.365 1.041
ENSG00000234350 E008 1.6315183 0.009676551 0.19504568 0.32004243 2 170723504 170723593 90 - 0.552 0.299 -1.372
ENSG00000234350 E009 0.0000000       2 170723594 170723797 204 -      
ENSG00000234350 E010 0.0000000       2 170723798 170724622 825 -      
ENSG00000234350 E011 2.6697700 0.133086763 0.15619921 0.27006418 2 170724623 170725717 1095 - 0.467 0.633 0.771
ENSG00000234350 E012 0.2987644 0.031469719 0.30288580   2 170725718 170725736 19 - 0.215 0.000 -12.467
ENSG00000234350 E013 0.9222279 0.014018736 0.82314513 0.88853543 2 170725737 170726042 306 - 0.293 0.299 0.043
ENSG00000234350 E014 0.6234634 0.020114528 0.22927534 0.36157708 2 170726043 170726089 47 - 0.121 0.299 1.627
ENSG00000234350 E015 1.2189160 0.011294660 0.64223361 0.75506231 2 170727285 170727328 44 - 0.415 0.299 -0.694
ENSG00000234350 E016 0.4449813 0.023716129 0.73126874 0.82296730 2 170727659 170727718 60 - 0.215 0.124 -0.957
ENSG00000234350 E017 0.5901540 0.021156639 0.42517356 0.56811937 2 170727719 170727788 70 - 0.292 0.124 -1.542
ENSG00000234350 E018 0.0000000       2 170727789 170727855 67 -      
ENSG00000234350 E019 1.7399663 0.010443541 0.01078721 0.03065685 2 170728579 170730037 1459 - 0.215 0.598 2.210
ENSG00000234350 E020 1.6575546 0.011358028 0.52382251 0.65744422 2 170730368 170730932 565 - 0.511 0.365 -0.765
ENSG00000234350 E021 0.3289534 0.036629343 0.88449298   2 170730933 170730951 19 - 0.121 0.124 0.046
ENSG00000234350 E022 0.1817044 0.179003308 0.37836021   2 170730952 170730997 46 - 0.000 0.124 11.285
ENSG00000234350 E023 0.1482932 0.042920437 0.37865675   2 170733879 170733994 116 - 0.000 0.124 11.278
ENSG00000234350 E024 2.0691232 0.007994770 0.94887509 0.97194249 2 170740632 170741287 656 - 0.511 0.475 -0.178
ENSG00000234350 E025 0.0000000       2 170743892 170743956 65 -      
ENSG00000234350 E026 0.0000000       2 170769714 170770693 980 -      
ENSG00000234350 E027 0.0000000       2 170770694 170770701 8 -      
ENSG00000234350 E028 0.8857980 0.015378759 0.01504074 0.04058141 2 170770702 170770824 123 - 0.466 0.000 -14.052
ENSG00000234350 E029 0.0000000       2 170813589 170813670 82 -