ENSG00000234147

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000683340 ENSG00000234147 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 41.37459 90.02863 24.64742 0.4436351 1.413552 -1.868522 14.90938 34.03074 10.683235 0.857575 0.2382295 -1.670564 0.3553375 0.3781333 0.4351333 0.05700000 0.19948738 0.000859809    
ENST00000683641 ENSG00000234147 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 41.37459 90.02863 24.64742 0.4436351 1.413552 -1.868522 19.53351 43.43476 9.648472 1.165694 0.7716155 -2.169315 0.4647042 0.4823667 0.3907000 -0.09166667 0.01370481 0.000859809    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000234147 E001 0.0000000       6 140575812 140576557 746 -      
ENSG00000234147 E002 0.8460400 0.2619971566 4.718759e-01 6.109545e-01 6 140602135 140602236 102 - 0.000 0.227 10.721
ENSG00000234147 E003 1.0277444 0.1905947380 3.288857e-01 4.723760e-01 6 140602329 140602369 41 - 0.000 0.267 12.310
ENSG00000234147 E004 0.2214452 0.0407664988 1.000000e+00   6 140610620 140610679 60 - 0.000 0.066 10.445
ENSG00000234147 E005 0.0000000       6 140620904 140620907 4 -      
ENSG00000234147 E006 0.1817044 0.0409573803 1.000000e+00   6 140620908 140620995 88 - 0.000 0.066 10.440
ENSG00000234147 E007 0.7029582 0.0172671820 8.105522e-01 8.797894e-01 6 140651478 140651561 84 - 0.216 0.174 -0.393
ENSG00000234147 E008 0.0000000       6 140663829 140663943 115 -      
ENSG00000234147 E009 2.2153281 0.0068585535 4.115364e-04 1.818707e-03 6 140811564 140811718 155 - 0.833 0.260 -2.827
ENSG00000234147 E010 0.2214452 0.0407664988 1.000000e+00   6 140816012 140816131 120 - 0.000 0.066 10.445
ENSG00000234147 E011 3.1083966 0.0068251831 2.107740e-03 7.557727e-03 6 140816132 140816230 99 - 0.873 0.394 -2.131
ENSG00000234147 E012 2.3143234 0.0067413579 3.011752e-02 7.219356e-02 6 140845958 140845971 14 - 0.000 0.496 14.502
ENSG00000234147 E013 3.3366831 0.0295649054 7.451510e-02 1.507639e-01 6 140845972 140845995 24 - 0.216 0.596 2.190
ENSG00000234147 E014 472.9613945 0.0002868771 2.054898e-06 1.594292e-05 6 140845996 140846284 289 - 2.472 2.572 0.335
ENSG00000234147 E015 235.5107700 0.0013713693 6.209189e-03 1.916536e-02 6 140846285 140846304 20 - 2.177 2.271 0.316
ENSG00000234147 E016 4.7950908 0.0033242335 1.418516e-01 2.505698e-01 6 140846381 140846567 187 - 0.833 0.614 -0.900
ENSG00000234147 E017 3.4946830 0.0971112712 4.014068e-03 1.318132e-02 6 140846568 140847826 1259 - 0.941 0.398 -2.368
ENSG00000234147 E018 3.9187601 0.0176516017 1.443400e-01 2.539212e-01 6 140847827 140847907 81 - 0.790 0.558 -0.986
ENSG00000234147 E019 3.0345151 0.0650821337 1.440038e-03 5.439465e-03 6 140847908 140849007 1100 - 0.909 0.335 -2.611
ENSG00000234147 E020 194.1885856 0.0002986640 3.651135e-01 5.094508e-01 6 140852819 140852912 94 - 2.195 2.168 -0.090
ENSG00000234147 E021 99.1084419 0.0004616821 1.172801e-01 2.160625e-01 6 140852913 140852924 12 - 1.933 1.865 -0.227
ENSG00000234147 E022 2.8441867 0.0070578042 3.062342e-01 4.483916e-01 6 140852925 140853769 845 - 0.626 0.448 -0.839
ENSG00000234147 E023 4.7846006 0.0033800091 1.507058e-05 9.616286e-05 6 140853770 140856525 2756 - 1.079 0.496 -2.366
ENSG00000234147 E024 0.8502072 0.0143679670 3.161996e-01 4.589640e-01 6 140858673 140858830 158 - 0.360 0.174 -1.394
ENSG00000234147 E025 0.7394768 0.0203609972 4.048574e-01 5.485466e-01 6 140865709 140865806 98 - 0.000 0.219 12.628
ENSG00000234147 E026 1.1792493 0.0176313612 4.170634e-03 1.362242e-02 6 140895645 140895728 84 - 0.626 0.123 -3.297
ENSG00000234147 E027 8.4359246 0.0019914169 2.907418e-01 4.315382e-01 6 140895803 140895930 128 - 0.973 0.839 -0.509
ENSG00000234147 E028 208.3695558 0.0002459257 2.675129e-01 4.058419e-01 6 140898188 140898190 3 - 2.173 2.209 0.119
ENSG00000234147 E029 466.5896288 0.0001301221 3.735687e-01 5.179941e-01 6 140898191 140898290 100 - 2.563 2.547 -0.053
ENSG00000234147 E030 358.0819754 0.0001620218 1.516119e-01 2.638527e-01 6 140898291 140898376 86 - 2.459 2.428 -0.103
ENSG00000234147 E031 242.0086446 0.0008106587 3.560765e-01 5.004609e-01 6 140898377 140898380 4 - 2.285 2.258 -0.091
ENSG00000234147 E032 250.2286391 0.0011296685 1.784602e-01 2.992216e-01 6 140898381 140898448 68 - 2.311 2.270 -0.136