ENSG00000234127

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000437089 ENSG00000234127 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM26 protein_coding protein_coding 32.15159 48.4388 22.49405 1.80372 0.7940915 -1.106276 6.640402 13.773385 2.330634 1.5404250 1.0619391 -2.5579587 0.18402083 0.2861333 0.10726667 -0.17886667 0.10339632 0.02349764 FALSE  
ENST00000453195 ENSG00000234127 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM26 protein_coding protein_coding 32.15159 48.4388 22.49405 1.80372 0.7940915 -1.106276 12.794639 18.429216 9.961599 1.3785820 0.9011999 -0.8868806 0.40055000 0.3808000 0.44110000 0.06030000 0.50216783 0.02349764 FALSE  
ENST00000454678 ENSG00000234127 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM26 protein_coding protein_coding 32.15159 48.4388 22.49405 1.80372 0.7940915 -1.106276 3.052761 5.509556 1.355918 0.8309947 0.6934279 -2.0146809 0.08903333 0.1133000 0.05846667 -0.05483333 0.43271784 0.02349764 FALSE  
MSTRG.27926.5 ENSG00000234127 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM26 protein_coding   32.15159 48.4388 22.49405 1.80372 0.7940915 -1.106276 4.343060 5.427966 4.277070 0.7984000 0.3104487 -0.3430753 0.14801250 0.1111333 0.18963333 0.07850000 0.02349764 0.02349764 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000234127 E001 561.388239 0.0040362786 1.982676e-08 2.313736e-07 6 30184455 30184831 377 - 2.514 2.734 0.730
ENSG00000234127 E002 1671.041485 0.0010914658 9.134518e-05 4.812713e-04 6 30184832 30186174 1343 - 3.097 3.180 0.276
ENSG00000234127 E003 491.923154 0.0001188484 4.669513e-01 6.064727e-01 6 30186175 30186558 384 - 2.620 2.634 0.045
ENSG00000234127 E004 124.691795 0.0002918762 5.636616e-01 6.911093e-01 6 30189167 30189199 33 - 2.002 2.049 0.159
ENSG00000234127 E005 191.904606 0.0002279876 7.823094e-01 8.602334e-01 6 30189418 30189533 116 - 2.211 2.229 0.061
ENSG00000234127 E006 14.673767 0.0164846519 4.459755e-01 5.875310e-01 6 30189534 30190012 479 - 1.172 1.111 -0.218
ENSG00000234127 E007 133.776994 0.0015564599 2.363200e-01 3.699031e-01 6 30190013 30190035 23 - 2.081 2.061 -0.065
ENSG00000234127 E008 10.879809 0.0023505930 5.124156e-02 1.113629e-01 6 30190036 30190394 359 - 1.140 0.957 -0.667
ENSG00000234127 E009 114.651706 0.0068308816 8.161767e-01 8.836956e-01 6 30196516 30196535 20 - 1.988 2.004 0.054
ENSG00000234127 E010 300.447233 0.0021063665 5.274183e-02 1.140302e-01 6 30196536 30196746 211 - 2.441 2.408 -0.109
ENSG00000234127 E011 202.720552 0.0002450918 3.542794e-01 4.985602e-01 6 30198429 30198490 62 - 2.246 2.246 0.000
ENSG00000234127 E012 153.178545 0.0003894446 5.034495e-02 1.097751e-01 6 30198491 30198524 34 - 2.152 2.115 -0.125
ENSG00000234127 E013 182.771005 0.0001954764 1.605396e-03 5.978485e-03 6 30198666 30198737 72 - 2.249 2.184 -0.217
ENSG00000234127 E014 130.637390 0.0002842164 3.370968e-03 1.135284e-02 6 30198738 30198763 26 - 2.111 2.037 -0.248
ENSG00000234127 E015 259.015584 0.0001686510 3.541912e-07 3.227380e-06 6 30198764 30198990 227 - 2.421 2.326 -0.320
ENSG00000234127 E016 198.509464 0.0002446510 3.065185e-06 2.288395e-05 6 30198991 30199147 157 - 2.311 2.208 -0.343
ENSG00000234127 E017 87.425177 0.0003385392 6.447458e-03 1.978668e-02 6 30199148 30199153 6 - 1.945 1.858 -0.293
ENSG00000234127 E018 8.123145 0.0369526373 5.270423e-01 6.601994e-01 6 30199154 30199264 111 - 0.963 0.891 -0.274
ENSG00000234127 E019 92.000564 0.0002905671 6.815662e-03 2.074361e-02 6 30201035 30201083 49 - 1.967 1.884 -0.278
ENSG00000234127 E020 96.452814 0.0042281447 1.332364e-01 2.386303e-01 6 30201084 30201123 40 - 1.962 1.914 -0.163
ENSG00000234127 E021 69.594541 0.0004450276 8.934743e-01 9.358972e-01 6 30201124 30201138 15 - 1.763 1.795 0.110
ENSG00000234127 E022 108.137093 0.0030602099 2.151054e-01 3.445626e-01 6 30204656 30204765 110 - 1.997 1.967 -0.102
ENSG00000234127 E023 96.982731 0.0071313841 1.422254e-01 2.510708e-01 6 30213305 30213427 123 - 1.967 1.911 -0.190