ENSG00000233593

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000435649 ENSG00000233593 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC02609 lncRNA lncRNA 10.04397 12.6066 9.139856 1.288318 1.124789 -0.4635027 0.3716095 0.0000000 0.5955733 0.00000000 0.59557331 5.920230 0.03395833 0.000000000 0.05996667 0.05996667 7.930573e-01 7.24477e-15   FALSE
ENST00000635581 ENSG00000233593 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC02609 lncRNA lncRNA 10.04397 12.6066 9.139856 1.288318 1.124789 -0.4635027 2.5742392 5.0397569 0.6084037 1.35915287 0.60840367 -3.029593 0.26711667 0.390633333 0.08790000 -0.30273333 9.268578e-02 7.24477e-15   FALSE
ENST00000635959 ENSG00000233593 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC02609 lncRNA lncRNA 10.04397 12.6066 9.139856 1.288318 1.124789 -0.4635027 0.7997625 1.9047868 0.0000000 0.44917242 0.00000000 -7.581040 0.07367500 0.148533333 0.00000000 -0.14853333 7.244770e-15 7.24477e-15   FALSE
ENST00000664774 ENSG00000233593 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC02609 lncRNA lncRNA 10.04397 12.6066 9.139856 1.288318 1.124789 -0.4635027 0.3320625 0.1053881 0.6245094 0.10538810 0.13466463 2.459147 0.03748750 0.009833333 0.07376667 0.06393333 9.490424e-02 7.24477e-15   FALSE
ENST00000670028 ENSG00000233593 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC02609 lncRNA lncRNA 10.04397 12.6066 9.139856 1.288318 1.124789 -0.4635027 0.8158319 1.0429460 0.3579434 0.06228108 0.05148515 -1.516875 0.08327083 0.083500000 0.04046667 -0.04303333 2.984508e-02 7.24477e-15   FALSE
MSTRG.1581.12 ENSG00000233593 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC02609 lncRNA   10.04397 12.6066 9.139856 1.288318 1.124789 -0.4635027 3.1239393 2.1328427 4.7937948 1.30679601 1.12094002 1.164649 0.29400833 0.183633333 0.50950000 0.32586667 4.646592e-01 7.24477e-15   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000233593 E001 1.0350190 0.0170438098 3.425468e-01 4.865455e-01 1 90769086 90771067 1982 - 0.162 0.336 1.364
ENSG00000233593 E002 0.4460135 0.0277810148 2.397466e-02 5.975411e-02 1 90778451 90782512 4062 - 0.373 0.000 -14.021
ENSG00000233593 E003 1.3952967 0.0113841385 5.178119e-02 1.123314e-01 1 90782513 90782983 471 - 0.571 0.230 -1.958
ENSG00000233593 E004 20.3510903 0.0016996973 5.943404e-03 1.845957e-02 1 90782984 90783133 150 - 1.137 1.364 0.801
ENSG00000233593 E005 65.9553754 0.0005047382 2.769478e-08 3.139476e-07 1 90783134 90783423 290 - 1.607 1.861 0.859
ENSG00000233593 E006 34.4415395 0.0007742453 1.851823e-02 4.827078e-02 1 90789398 90789487 90 - 1.414 1.556 0.489
ENSG00000233593 E007 0.5943067 0.0201882161 1.013158e-01 1.924749e-01 1 90789488 90789672 185 - 0.373 0.091 -2.544
ENSG00000233593 E008 4.5745946 0.0250961725 4.381363e-02 9.804812e-02 1 90807472 90808152 681 - 0.917 0.626 -1.168
ENSG00000233593 E009 1.1040064 0.5290540852 5.601037e-01 6.881276e-01 1 90822072 90822155 84 - 0.372 0.245 -0.840
ENSG00000233593 E010 0.8095083 0.7427564635 9.143256e-01 9.497494e-01 1 90822211 90822244 34 - 0.162 0.248 0.772
ENSG00000233593 E011 0.7718584 0.0163826824 2.481072e-01 3.836992e-01 1 90828555 90829546 992 - 0.373 0.166 -1.544
ENSG00000233593 E012 0.2903454 0.3161269671 1.321960e-01   1 90829547 90829592 46 - 0.280 0.000 -12.835
ENSG00000233593 E013 0.4418608 0.0269405767 2.394045e-02 5.968085e-02 1 90829593 90830075 483 - 0.373 0.000 -14.025
ENSG00000233593 E014 0.1515154 0.0442047716 2.653786e-01   1 90830076 90830078 3 - 0.162 0.000 -12.485
ENSG00000233593 E015 0.1515154 0.0442047716 2.653786e-01   1 90830079 90830083 5 - 0.162 0.000 -12.485
ENSG00000233593 E016 0.2998086 0.0281155194 6.362475e-01   1 90830084 90830136 53 - 0.162 0.091 -0.960
ENSG00000233593 E017 3.5071952 0.0099402284 1.152787e-02 3.241391e-02 1 90830137 90830417 281 - 0.866 0.491 -1.600
ENSG00000233593 E018 28.6407693 0.0006750233 2.940553e-20 1.934302e-18 1 90830418 90831787 1370 - 1.754 1.176 -1.994
ENSG00000233593 E019 4.3974459 0.0052504198 8.313272e-04 3.370913e-03 1 90831788 90831872 85 - 0.962 0.492 -1.956
ENSG00000233593 E020 2.3345782 0.0067153267 2.370151e-03 8.368460e-03 1 90831873 90831873 1 - 0.777 0.286 -2.418
ENSG00000233593 E021 2.8796914 0.0096234348 2.466732e-02 6.119652e-02 1 90831874 90831877 4 - 0.777 0.421 -1.610
ENSG00000233593 E022 13.6593521 0.0013868338 9.711259e-01 9.859637e-01 1 90831878 90831929 52 - 1.137 1.134 -0.011
ENSG00000233593 E023 17.2352508 0.0011648005 2.352921e-01 3.687054e-01 1 90831930 90831949 20 - 1.165 1.262 0.343
ENSG00000233593 E024 15.9914459 0.0018457646 3.668529e-01 5.111888e-01 1 90831950 90831952 3 - 1.151 1.227 0.269
ENSG00000233593 E025 86.2573565 0.0005477388 2.899630e-01 4.307166e-01 1 90831953 90832196 244 - 1.945 1.900 -0.150
ENSG00000233593 E026 0.5180316 0.0204321424 2.392478e-01 3.732365e-01 1 90832197 90832201 5 - 0.000 0.230 11.791
ENSG00000233593 E027 0.5085815 0.3685122182 1.000000e+00 1.000000e+00 1 90834386 90834509 124 - 0.162 0.167 0.056
ENSG00000233593 E028 0.1451727 0.0438281698 2.658603e-01   1 90834510 90834620 111 - 0.162 0.000 -12.486
ENSG00000233593 E029 0.3030308 0.4173904768 1.507808e-01   1 90834621 90834739 119 - 0.281 0.000 -12.744
ENSG00000233593 E030 1.9626472 0.0076732325 9.487962e-02 1.827041e-01 1 90834740 90835825 1086 - 0.621 0.336 -1.443
ENSG00000233593 E031 1.1342099 0.0132169135 2.270988e-01 3.589334e-01 1 90835826 90835938 113 - 0.449 0.231 -1.372
ENSG00000233593 E032 0.1817044 0.0439285055 8.484368e-01   1 90835939 90836001 63 - 0.000 0.091 10.246
ENSG00000233593 E033 0.3268771 0.0307979153 6.433683e-01   1 90836002 90836059 58 - 0.162 0.091 -0.957
ENSG00000233593 E034 0.9556260 0.0135568143 4.350839e-01 5.773175e-01 1 90836060 90836428 369 - 0.373 0.230 -0.958
ENSG00000233593 E035 7.5876058 0.0023243789 1.531005e-01 2.658860e-01 1 90837187 90837549 363 - 0.777 0.951 0.670
ENSG00000233593 E036 19.5989450 0.0236782147 3.848613e-01 5.290139e-01 1 90837550 90837765 216 - 1.227 1.298 0.249
ENSG00000233593 E037 55.2143142 0.0034944939 8.476090e-02 1.670224e-01 1 90851483 90851540 58 - 1.662 1.746 0.284
ENSG00000233593 E038 51.1138518 0.0007856108 3.476879e-01 4.918785e-01 1 90851541 90851669 129 - 1.657 1.697 0.134