ENSG00000233369

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000453092 ENSG00000233369 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2IP4 transcribed_processed_pseudogene transcribed_processed_pseudogene 47.09062 57.47439 40.59237 4.373098 1.104766 -0.5016062 14.282440 0.0000000 29.548966 0.0000000 2.1904434 11.529380 0.33547500 0.000000000 0.7304667 0.73046667 1.597044e-30 1.597044e-30 FALSE TRUE
ENST00000544802 ENSG00000233369 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2IP4 transcribed_processed_pseudogene processed_transcript 47.09062 57.47439 40.59237 4.373098 1.104766 -0.5016062 1.303536 0.2997281 3.316257 0.2007391 0.6657317 3.424825 0.03144583 0.005633333 0.0811000 0.07546667 1.728458e-02 1.597044e-30 FALSE TRUE
MSTRG.30034.2 ENSG00000233369 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2IP4 transcribed_processed_pseudogene   47.09062 57.47439 40.59237 4.373098 1.104766 -0.5016062 30.825842 57.1746618 7.727150 4.5230808 2.2072004 -2.885754 0.62251250 0.994366667 0.1884000 -0.80596667 1.232058e-07 1.597044e-30 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000233369 E001 4.9220514 0.1297432356 0.0292817086 0.070547122 7 73154938 73155343 406 + 0.959 0.512 -1.851
ENSG00000233369 E002 0.0000000       7 73155503 73155547 45 +      
ENSG00000233369 E003 0.1515154 0.0428781828 0.4660777427   7 73175415 73175525 111 + 0.126 0.000 -11.240
ENSG00000233369 E004 0.0000000       7 73176857 73176922 66 +      
ENSG00000233369 E005 0.2214452 0.0399735143 0.5089276936   7 73179087 73179270 184 + 0.000 0.119 10.159
ENSG00000233369 E006 0.3686942 0.0258823037 0.9686896914 0.984394638 7 73180539 73180597 59 + 0.126 0.119 -0.096
ENSG00000233369 E007 0.1472490 0.0428195621 0.4664377024   7 73182077 73182148 72 + 0.126 0.000 -11.240
ENSG00000233369 E008 3.5398623 0.0614547737 0.3179487493 0.460860266 7 73183115 73183298 184 + 0.731 0.552 -0.774
ENSG00000233369 E009 6.9009016 0.0544811805 0.1333376602 0.238756330 7 73184661 73184719 59 + 1.004 0.763 -0.922
ENSG00000233369 E010 16.0365052 0.0011061213 0.7616022217 0.845422913 7 73190066 73190137 72 + 1.217 1.239 0.078
ENSG00000233369 E011 31.9388193 0.0007106423 0.0875068138 0.171349609 7 73191371 73191451 81 + 1.569 1.462 -0.364
ENSG00000233369 E012 78.1221742 0.0004780671 0.0005999947 0.002533087 7 73191452 73191554 103 + 1.963 1.828 -0.454
ENSG00000233369 E013 47.4515123 0.0005450828 0.3842496992 0.528410975 7 73192497 73192555 59 + 1.706 1.660 -0.158
ENSG00000233369 E014 27.2350362 0.0029194699 0.0361645633 0.083905223 7 73192951 73193025 75 + 1.523 1.374 -0.512
ENSG00000233369 E015 16.0761896 0.0038120971 0.0722978748 0.147163085 7 73194626 73194727 102 + 1.312 1.153 -0.564
ENSG00000233369 E016 4.6532593 0.0035998905 0.2805262704 0.420380003 7 73195636 73195701 66 + 0.828 0.679 -0.602
ENSG00000233369 E017 1.8133218 0.0077825266 0.6919329758 0.793283991 7 73195879 73195959 81 + 0.480 0.410 -0.362
ENSG00000233369 E018 0.3729606 0.0259523527 0.9683309513 0.984227937 7 73195960 73196062 103 + 0.126 0.119 -0.097
ENSG00000233369 E019 0.4396707 0.0266190747 0.0768496517 0.154456720 7 73197964 73198019 56 + 0.303 0.000 -12.903
ENSG00000233369 E020 31.0819812 0.0006806789 0.0985802355 0.188327954 7 73198693 73198773 81 + 1.561 1.457 -0.354
ENSG00000233369 E021 101.2555817 0.0003894149 0.7945337462 0.868733823 7 73199696 73199779 84 + 2.017 2.005 -0.040
ENSG00000233369 E022 133.4245066 0.0004148253 0.5599362031 0.688003659 7 73200449 73200632 184 + 2.122 2.135 0.044
ENSG00000233369 E023 44.6743465 0.0005421213 0.0072660047 0.021916180 7 73202112 73202140 29 + 1.580 1.715 0.459
ENSG00000233369 E024 62.1076190 0.0004454112 0.0014670474 0.005530130 7 73203423 73203464 42 + 1.720 1.856 0.456
ENSG00000233369 E025 43.9209727 0.0005820318 0.0003969895 0.001762767 7 73204563 73204604 42 + 1.540 1.723 0.623
ENSG00000233369 E026 27.0176046 0.0007482839 0.0150910440 0.040692785 7 73205383 73205458 76 + 1.353 1.511 0.544
ENSG00000233369 E027 14.4912358 0.0013207000 0.0045763948 0.014753914 7 73206152 73207289 1138 + 1.032 1.284 0.901