ENSG00000232956

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000577700 ENSG00000232956 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG15 lncRNA lncRNA 90.20389 127.9076 75.6285 7.108394 1.113032 -0.7580216 2.516079 1.260774 4.661374 0.2103894 0.4117789 1.8781394 0.03149167 0.00980000 0.06153333 0.05173333 6.462867e-16 6.462867e-16   FALSE
ENST00000578968 ENSG00000232956 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG15 lncRNA lncRNA 90.20389 127.9076 75.6285 7.108394 1.113032 -0.7580216 58.463846 93.257424 45.350513 6.1722697 0.4830508 -1.0399363 0.62937083 0.72826667 0.59996667 -0.12830000 1.749814e-07 6.462867e-16   FALSE
ENST00000667119 ENSG00000232956 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG15 lncRNA lncRNA 90.20389 127.9076 75.6285 7.108394 1.113032 -0.7580216 8.152723 6.639207 7.579575 0.5669319 1.2491045 0.1908368 0.09847500 0.05256667 0.09980000 0.04723333 6.158148e-02 6.462867e-16   FALSE
ENST00000667823 ENSG00000232956 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG15 lncRNA lncRNA 90.20389 127.9076 75.6285 7.108394 1.113032 -0.7580216 4.990981 6.779200 1.834903 0.4960365 1.8349027 -1.8796969 0.05615417 0.05293333 0.02363333 -0.02930000 1.527128e-01 6.462867e-16   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000232956 E001 0.1817044 0.0431025508 7.996879e-01   7 44983019 44983022 4 - 0.000 0.093 8.248
ENSG00000232956 E002 0.8512514 0.0136968632 4.297528e-01 5.724261e-01 7 44983023 44983024 2 - 0.160 0.291 1.099
ENSG00000232956 E003 5.4464896 0.0036923788 9.993731e-03 2.874789e-02 7 44983025 44983033 9 - 0.508 0.871 1.531
ENSG00000232956 E004 9.2462849 0.0039431908 1.050356e-01 1.981388e-01 7 44983034 44983037 4 - 1.114 0.911 -0.749
ENSG00000232956 E005 9.9805674 0.0020816897 1.747989e-02 4.600026e-02 7 44983038 44983038 1 - 1.183 0.911 -0.994
ENSG00000232956 E006 166.7361446 0.0016389040 1.781707e-09 2.520453e-08 7 44983039 44983084 46 - 2.051 2.240 0.630
ENSG00000232956 E007 170.7123526 0.0016815596 8.334339e-09 1.042395e-07 7 44983085 44983085 1 - 2.070 2.247 0.594
ENSG00000232956 E008 317.5399113 0.0004853074 1.290928e-13 3.614580e-12 7 44983086 44983136 51 - 2.360 2.508 0.493
ENSG00000232956 E009 1197.8092807 0.0002915220 1.051867e-18 5.801256e-17 7 44983137 44983322 186 - 2.985 3.067 0.274
ENSG00000232956 E010 281.3823892 0.0051852572 1.029243e-14 3.379323e-13 7 44983323 44983821 499 - 2.621 2.284 -1.125
ENSG00000232956 E011 711.2051097 0.0003830902 3.850685e-06 2.812262e-05 7 44983822 44983846 25 - 2.784 2.831 0.155
ENSG00000232956 E012 1382.4524819 0.0001690328 1.159381e-05 7.591116e-05 7 44983847 44983957 111 - 3.093 3.111 0.060
ENSG00000232956 E013 1149.9594989 0.0003408194 2.060617e-05 1.274453e-04 7 44983958 44984046 89 - 3.006 3.033 0.089
ENSG00000232956 E014 287.8148057 0.0035336888 2.055060e-12 4.792282e-11 7 44984047 44984356 310 - 2.596 2.322 -0.915
ENSG00000232956 E015 863.9026347 0.0010916517 2.790451e-05 1.671703e-04 7 44984357 44984426 70 - 2.863 2.915 0.173
ENSG00000232956 E016 396.1609121 0.0067863144 3.021525e-19 1.769455e-17 7 44984427 44985377 951 - 2.806 2.393 -1.376
ENSG00000232956 E017 200.2123312 0.0098624147 1.098571e-20 7.643078e-19 7 44985378 44985881 504 - 2.565 2.027 -1.796
ENSG00000232956 E018 156.5313697 0.0023143959 4.272219e-15 1.483701e-13 7 44985882 44986020 139 - 2.356 2.042 -1.053
ENSG00000232956 E019 857.1983066 0.0017634947 5.493102e-02 1.178768e-01 7 44986021 44986097 77 - 2.888 2.901 0.045
ENSG00000232956 E020 58.3675210 0.0004239280 2.140383e-31 3.940614e-29 7 44986098 44986524 427 - 2.046 1.478 -1.924
ENSG00000232956 E021 686.8363760 0.0013833448 4.153361e-01 5.587294e-01 7 44986525 44986961 437 - 2.809 2.797 -0.040