ENSG00000232931

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000448494 ENSG00000232931 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 4.053602 2.86499 3.263758 0.6276609 0.1570113 0.1873906 0.9621930 0.8868128 0.2746702 0.50153025 0.27467021 -1.655515 0.20444583 0.2517333 0.08350000 -0.16823333 0.4990620038 0.0001473305 TRUE FALSE
ENST00000657232 ENSG00000232931 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 4.053602 2.86499 3.263758 0.6276609 0.1570113 0.1873906 0.0820442 0.0000000 0.2357806 0.00000000 0.07578666 4.619299 0.02694583 0.0000000 0.07030000 0.07030000 0.0007379010 0.0001473305 TRUE FALSE
ENST00000660608 ENSG00000232931 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 4.053602 2.86499 3.263758 0.6276609 0.1570113 0.1873906 0.1106411 0.2463694 0.0000000 0.24636939 0.00000000 -4.680152 0.04021667 0.1440667 0.00000000 -0.14406667 0.8234689663 0.0001473305 TRUE FALSE
ENST00000661329 ENSG00000232931 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 4.053602 2.86499 3.263758 0.6276609 0.1570113 0.1873906 0.4589647 0.1021630 0.6845555 0.01979042 0.05141760 2.630493 0.13288750 0.0439000 0.21220000 0.16830000 0.0001473305 0.0001473305   FALSE
ENST00000663557 ENSG00000232931 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 4.053602 2.86499 3.263758 0.6276609 0.1570113 0.1873906 1.8028578 0.7267953 1.5736806 0.33282654 0.35451363 1.103946 0.42552917 0.2528667 0.48330000 0.23043333 0.3669192559 0.0001473305 TRUE FALSE
MSTRG.18864.1 ENSG00000232931 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   4.053602 2.86499 3.263758 0.6276609 0.1570113 0.1873906 0.0758012 0.3747543 0.1235209 0.37475432 0.12352090 -1.526872 0.02817917 0.1242333 0.03506667 -0.08916667 0.9701294979 0.0001473305   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000232931 E001 0.1482932 0.0448141205 4.098237e-01   2 95807052 95807053 2 - 0.000 0.121 9.786
ENSG00000232931 E002 0.1482932 0.0448141205 4.098237e-01   2 95807054 95807054 1 - 0.000 0.121 11.621
ENSG00000232931 E003 0.1482932 0.0448141205 4.098237e-01   2 95807055 95807060 6 - 0.000 0.121 11.621
ENSG00000232931 E004 0.1482932 0.0448141205 4.098237e-01   2 95807061 95807069 9 - 0.000 0.121 11.621
ENSG00000232931 E005 0.5117019 0.2034591746 7.646846e-02 1.538489e-01 2 95807070 95807081 12 - 0.000 0.292 12.711
ENSG00000232931 E006 0.5451131 0.9988374404 3.234836e-01 4.668149e-01 2 95807082 95807117 36 - 0.000 0.296 12.189
ENSG00000232931 E007 17.7652623 0.0420809480 4.729857e-03 1.517738e-02 2 95807118 95807302 185 - 1.098 1.372 0.966
ENSG00000232931 E008 2.7697896 0.1362506507 1.969011e-01 3.223554e-01 2 95813316 95813533 218 - 0.474 0.652 0.818
ENSG00000232931 E009 0.4772466 0.0235469468 4.684294e-01 6.078465e-01 2 95813534 95813536 3 - 0.124 0.216 0.966
ENSG00000232931 E010 1.6136345 0.0238191233 3.277415e-01 4.712150e-01 2 95813537 95813809 273 - 0.519 0.294 -1.251
ENSG00000232931 E011 1.7338256 0.0145067353 3.692529e-01 5.136791e-01 2 95813810 95813908 99 - 0.365 0.467 0.554
ENSG00000232931 E012 1.8758753 0.0084843096 2.780995e-02 6.763954e-02 2 95813909 95813957 49 - 0.220 0.554 1.970
ENSG00000232931 E013 0.8062886 0.0309825263 2.366885e-01 3.703483e-01 2 95813958 95814049 92 - 0.365 0.121 -2.029
ENSG00000232931 E014 23.6021814 0.0081767738 4.094830e-04 1.810846e-03 2 95814050 95814145 96 - 1.250 1.460 0.730
ENSG00000232931 E015 44.0367051 0.0007026146 7.705197e-05 4.141068e-04 2 95814146 95814570 425 - 1.567 1.687 0.411
ENSG00000232931 E016 19.2665933 0.0010121109 4.549042e-04 1.986177e-03 2 95814571 95814670 100 - 1.171 1.366 0.685
ENSG00000232931 E017 20.8844666 0.0009105618 8.023189e-04 3.267767e-03 2 95814671 95814791 121 - 1.217 1.389 0.604
ENSG00000232931 E018 89.2737075 0.0038824269 1.576828e-01 2.720383e-01 2 95814792 95816723 1932 - 1.943 1.932 -0.035
ENSG00000232931 E019 102.3065773 0.0282647745 8.509894e-07 7.176061e-06 2 95816724 95819724 3001 - 2.174 1.797 -1.264
ENSG00000232931 E020 2.3669322 0.0063406823 3.859822e-02 8.844761e-02 2 95824201 95824312 112 - 0.695 0.294 -2.032
ENSG00000232931 E021 14.9177349 0.0093224053 1.700223e-09 2.414016e-08 2 95828204 95829887 1684 - 1.457 0.741 -2.618
ENSG00000232931 E022 2.4669753 0.1835233070 9.149060e-01 9.501126e-01 2 95833735 95833963 229 - 0.561 0.515 -0.214
ENSG00000232931 E023 0.5149242 0.4260685114 5.438568e-01 6.744067e-01 2 95834978 95835003 26 - 0.124 0.217 0.974