ENSG00000232677

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000449434 ENSG00000232677 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00665 lncRNA lncRNA 7.272725 10.46467 6.074181 0.4818119 0.06738359 -0.7837702 1.0301075 2.0902453 1.3414452 0.1905320 0.15485619 -0.6360549 0.12751250 0.1993000 0.22130000 0.02200000 0.84463033 0.007685585   FALSE
ENST00000591372 ENSG00000232677 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00665 lncRNA lncRNA 7.272725 10.46467 6.074181 0.4818119 0.06738359 -0.7837702 0.5103991 0.2243848 1.0177012 0.2243848 0.11778452 2.1324699 0.08341667 0.0214000 0.16716667 0.14576667 0.05536625 0.007685585 FALSE TRUE
ENST00000651681 ENSG00000232677 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00665 lncRNA lncRNA 7.272725 10.46467 6.074181 0.4818119 0.06738359 -0.7837702 2.2799031 3.9123244 1.5303773 0.3972778 0.05753556 -1.3484251 0.29011250 0.3719667 0.25206667 -0.11990000 0.01910344 0.007685585 FALSE FALSE
ENST00000666458 ENSG00000232677 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00665 lncRNA lncRNA 7.272725 10.46467 6.074181 0.4818119 0.06738359 -0.7837702 0.6683441 1.3726880 0.4908114 0.2319549 0.02950053 -1.4651365 0.09874167 0.1307333 0.08076667 -0.04996667 0.24821018 0.007685585 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000232677 E001 0.0000000       19 36259540 36259939 400 -      
ENSG00000232677 E002 0.0000000       19 36262260 36262675 416 -      
ENSG00000232677 E003 0.0000000       19 36262676 36262860 185 -      
ENSG00000232677 E004 0.1817044 0.0399274729 8.139114e-01   19 36264645 36264880 236 - 0.000 0.095 9.208
ENSG00000232677 E005 0.3666179 0.0316403756 6.801768e-01 7.841312e-01 19 36312586 36313060 475 - 0.157 0.095 -0.839
ENSG00000232677 E006 0.0000000       19 36313061 36313066 6 -      
ENSG00000232677 E007 1.2563901 0.0951939021 1.923252e-01 3.166785e-01 19 36313067 36313093 27 - 0.157 0.426 1.933
ENSG00000232677 E008 20.6238688 0.0011689343 3.062417e-02 7.318579e-02 19 36313094 36313322 229 - 1.187 1.359 0.604
ENSG00000232677 E009 8.6101916 0.0021548682 1.406911e-02 3.838184e-02 19 36313323 36313912 590 - 0.729 1.030 1.157
ENSG00000232677 E010 0.1482932 0.0414602016 8.151690e-01   19 36313913 36313958 46 - 0.000 0.094 11.491
ENSG00000232677 E011 2.3238779 0.0064436784 9.803816e-01 9.917383e-01 19 36313959 36314931 973 - 0.502 0.503 0.005
ENSG00000232677 E012 0.6642364 0.0883802755 5.954611e-01 7.175554e-01 19 36314932 36315004 73 - 0.272 0.172 -0.841
ENSG00000232677 E013 0.2955422 0.0295294697 6.741696e-01   19 36315005 36315034 30 - 0.157 0.094 -0.845
ENSG00000232677 E014 0.0000000       19 36315035 36315173 139 -      
ENSG00000232677 E015 0.6017953 0.1659105747 1.751019e-02 4.606337e-02 19 36315174 36315216 43 - 0.439 0.000 -14.843
ENSG00000232677 E016 0.6017953 0.1659105747 1.751019e-02 4.606337e-02 19 36315217 36315219 3 - 0.439 0.000 -14.843
ENSG00000232677 E017 2.7439662 0.0630154344 7.063195e-01 8.044712e-01 19 36315220 36315523 304 - 0.503 0.565 0.294
ENSG00000232677 E018 1.9990891 0.0178997459 1.510891e-01 2.631478e-01 19 36315524 36315528 5 - 0.272 0.534 1.474
ENSG00000232677 E019 1.8111292 0.0229446159 2.791899e-01 4.189009e-01 19 36315529 36315575 47 - 0.272 0.470 1.161
ENSG00000232677 E020 6.7031416 0.0028858122 5.913309e-03 1.838268e-02 19 36315576 36315956 381 - 0.558 0.943 1.573
ENSG00000232677 E021 25.3962750 0.0008747211 2.479902e-01 3.835560e-01 19 36315957 36316038 82 - 1.341 1.419 0.272
ENSG00000232677 E022 14.4271381 0.0013184907 4.393395e-02 9.826397e-02 19 36316039 36316070 32 - 1.276 1.094 -0.646
ENSG00000232677 E023 0.8908930 0.2315830767 4.924359e-01 6.296180e-01 19 36316178 36316257 80 - 0.363 0.232 -0.892
ENSG00000232677 E024 1.4735689 0.0107398023 9.298497e-02 1.797906e-01 19 36316258 36316348 91 - 0.157 0.468 2.155
ENSG00000232677 E025 1.8883612 0.0098822431 8.542564e-01 9.098368e-01 19 36316349 36316517 169 - 0.438 0.468 0.154
ENSG00000232677 E026 1.9229314 0.2168690757 7.808063e-01 8.591719e-01 19 36317635 36318550 916 - 0.503 0.426 -0.391
ENSG00000232677 E027 0.0000000       19 36319711 36319715 5 -      
ENSG00000232677 E028 6.6657477 0.1091408307 9.531803e-01 9.747115e-01 19 36319716 36320282 567 - 0.852 0.868 0.061
ENSG00000232677 E029 7.0112872 0.0027131577 8.805224e-01 9.273655e-01 19 36320283 36320571 289 - 0.877 0.892 0.056
ENSG00000232677 E030 6.1528354 0.0027065665 9.974143e-01 1.000000e+00 19 36320572 36320760 189 - 0.824 0.819 -0.019
ENSG00000232677 E031 0.0000000       19 36321030 36321299 270 -      
ENSG00000232677 E032 15.3979863 0.0013508828 4.582939e-01 5.986313e-01 19 36321300 36321357 58 - 1.234 1.165 -0.245
ENSG00000232677 E033 13.0842396 0.0076695477 2.706115e-01 4.092558e-01 19 36321993 36322030 38 - 1.199 1.085 -0.408
ENSG00000232677 E034 5.5524781 0.1304399317 3.337143e-01 4.774508e-01 19 36322130 36322208 79 - 0.901 0.706 -0.771
ENSG00000232677 E035 3.4238333 0.0144130287 2.305808e-01 3.631552e-01 19 36322209 36322222 14 - 0.729 0.537 -0.837
ENSG00000232677 E036 1.7274975 0.0086736665 2.180343e-01 3.480536e-01 19 36322223 36322225 3 - 0.558 0.345 -1.106
ENSG00000232677 E037 0.0000000       19 36322226 36322384 159 -      
ENSG00000232677 E038 0.3634088 0.3530976927 5.002765e-01   19 36324907 36324907 1 - 0.000 0.173 11.928
ENSG00000232677 E039 3.5886739 0.0563401304 4.950512e-01 6.319256e-01 19 36324908 36324923 16 - 0.558 0.684 0.550
ENSG00000232677 E040 3.7703783 0.0264816105 3.657053e-01 5.100023e-01 19 36324924 36324925 2 - 0.558 0.708 0.649
ENSG00000232677 E041 123.7345054 0.0005168706 9.291906e-06 6.221764e-05 19 36324926 36325764 839 - 1.970 2.109 0.464
ENSG00000232677 E042 17.0969262 0.0011823395 8.177771e-01 8.847926e-01 19 36325765 36325887 123 - 1.222 1.237 0.053
ENSG00000232677 E043 7.6105242 0.0022110410 6.291267e-01 7.445552e-01 19 36325888 36325896 9 - 0.877 0.931 0.204
ENSG00000232677 E044 11.9512843 0.0020466728 5.202731e-01 6.542511e-01 19 36325897 36326052 156 - 1.042 1.103 0.219
ENSG00000232677 E045 13.5693514 0.0038637604 6.375820e-01 7.514355e-01 19 36326053 36326289 237 - 1.174 1.126 -0.173
ENSG00000232677 E046 13.3909972 0.0014254091 2.179777e-01 3.479837e-01 19 36326290 36326481 192 - 1.211 1.094 -0.418
ENSG00000232677 E047 18.4032956 0.0010810382 1.386413e-01 2.462191e-01 19 36326482 36326672 191 - 1.341 1.219 -0.428
ENSG00000232677 E048 16.4122322 0.0011886164 8.833217e-02 1.725787e-01 19 36326673 36326753 81 - 1.305 1.157 -0.520
ENSG00000232677 E049 21.7977042 0.0018843451 1.086724e-01 2.035722e-01 19 36326754 36326953 200 - 1.405 1.279 -0.439
ENSG00000232677 E050 10.6606671 0.0398207823 6.191041e-01 7.365912e-01 19 36326954 36326996 43 - 1.075 1.007 -0.250
ENSG00000232677 E051 21.6171483 0.0026044004 1.464074e-02 3.968642e-02 19 36326997 36327170 174 - 1.441 1.250 -0.663
ENSG00000232677 E052 6.3076788 0.0026484064 4.110123e-03 1.345145e-02 19 36327171 36327225 55 - 1.042 0.689 -1.366
ENSG00000232677 E053 0.7426990 0.0535253243 6.442064e-01 7.565648e-01 19 36327226 36327275 50 - 0.157 0.239 0.748
ENSG00000232677 E054 2.4304425 0.0062409216 4.059178e-01 5.495756e-01 19 36328694 36330252 1559 - 0.607 0.469 -0.650
ENSG00000232677 E055 74.1067280 0.0062159616 2.720605e-01 4.108952e-01 19 36330253 36330492 240 - 1.885 1.821 -0.217
ENSG00000232677 E056 0.0000000       19 36330493 36330518 26 -      
ENSG00000232677 E057 22.3479592 0.0014906136 5.522613e-01 6.815602e-01 19 36331447 36331453 7 - 1.366 1.316 -0.174
ENSG00000232677 E058 58.0688544 0.0004521492 9.197256e-01 9.532887e-01 19 36331454 36331687 234 - 1.747 1.738 -0.032
ENSG00000232677 E059 17.2040404 0.0011381781 3.551162e-01 4.994731e-01 19 36331688 36331726 39 - 1.174 1.250 0.266
ENSG00000232677 E060 5.6066159 0.0030029870 9.293114e-01 9.595464e-01 19 36331727 36331770 44 - 0.794 0.802 0.031