ENSG00000232593

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000366185 ENSG00000232593 HEK293_OSMI2_2hA HEK293_TMG_2hB KANTR protein_coding processed_transcript 2.340442 2.061248 1.833946 0.403923 0.215386 -0.1677043 0.2241718 0.1797966 0.3601479 0.04363316 0.09773749 0.9636474 0.10610833 0.08646667 0.1902000 0.1037333 1.637745e-01 1.236783e-07 FALSE FALSE
ENST00000603385 ENSG00000232593 HEK293_OSMI2_2hA HEK293_TMG_2hB KANTR protein_coding processed_transcript 2.340442 2.061248 1.833946 0.403923 0.215386 -0.1677043 0.4086462 0.1119430 0.4163174 0.06463716 0.07117359 1.8057209 0.19688750 0.04483333 0.2246333 0.1798000 9.231074e-04 1.236783e-07   FALSE
MSTRG.34287.5 ENSG00000232593 HEK293_OSMI2_2hA HEK293_TMG_2hB KANTR protein_coding   2.340442 2.061248 1.833946 0.403923 0.215386 -0.1677043 1.3675834 1.2547021 0.9493261 0.24316560 0.02461508 -0.3987045 0.55125417 0.60880000 0.5280000 -0.0808000 5.616041e-01 1.236783e-07   FALSE
MSTRG.34287.7 ENSG00000232593 HEK293_OSMI2_2hA HEK293_TMG_2hB KANTR protein_coding   2.340442 2.061248 1.833946 0.403923 0.215386 -0.1677043 0.2167356 0.4166425 0.0000000 0.09587652 0.00000000 -5.4149557 0.08452083 0.20513333 0.0000000 -0.2051333 1.236783e-07 1.236783e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000232593 E001 0.2998086 0.0296002783 0.8902513131   X 53094145 53094147 3 + 0.129 0.116 -0.186
ENSG00000232593 E002 0.5932745 0.0792962797 0.8577266218 0.912136756 X 53094148 53094156 9 + 0.229 0.206 -0.196
ENSG00000232593 E003 0.7405235 0.0172434181 0.5122594431 0.647171897 X 53094157 53094181 25 + 0.310 0.207 -0.771
ENSG00000232593 E004 0.9190056 0.1223138382 0.6065488028 0.726659527 X 53094182 53094188 7 + 0.229 0.343 0.793
ENSG00000232593 E005 2.6120357 0.0833567671 0.1798517254 0.300992666 X 53094189 53094284 96 + 0.682 0.449 -1.071
ENSG00000232593 E006 1.7682705 0.0082211007 0.2228668169 0.353788303 X 53094400 53094450 51 + 0.535 0.347 -0.990
ENSG00000232593 E007 1.4059189 0.0102925165 0.2001697518 0.326462512 X 53094451 53094474 24 + 0.489 0.282 -1.184
ENSG00000232593 E008 7.3240520 0.0101663185 0.0098836790 0.028478507 X 53099472 53099608 137 + 1.057 0.770 -1.091
ENSG00000232593 E009 11.3253394 0.1267563724 0.9535134019 0.974900311 X 53123469 53127445 3977 + 1.096 1.083 -0.046
ENSG00000232593 E010 3.4136201 0.0051958250 0.0096544176 0.027913443 X 53141848 53142094 247 + 0.816 0.452 -1.599
ENSG00000232593 E011 3.3750106 0.0071900016 0.0168220891 0.044538576 X 53142095 53142598 504 + 0.793 0.452 -1.504
ENSG00000232593 E012 6.8396592 0.0030655483 0.0012096947 0.004673662 X 53142599 53143451 853 + 1.057 0.697 -1.389
ENSG00000232593 E013 9.0532368 0.0020533572 0.2747786350 0.414000334 X 53166921 53166979 59 + 0.900 1.045 0.540
ENSG00000232593 E014 51.6592261 0.0006752302 0.1720284170 0.290843237 X 53166980 53168026 1047 + 1.722 1.690 -0.105
ENSG00000232593 E015 143.0978376 0.0073346578 0.0002710704 0.001262035 X 53168027 53171251 3225 + 2.059 2.201 0.476